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To verify the proposed method, experiments on both public datasets and customized motion phantom for respiratory simulation were performed. In the public dataset study, an average mean absolute error, and an average root-mean-square error of predictive results of 0.44 and 0.58 mm were achieved, respectively. In the motion phantom study, an average root mean square of puncturing error resulted in 0.65 mm.
The experimental results demonstrate the proposed method improves the accuracy of target localization during respiratory movement and appeals the potentials applying to clinical application.
The experimental results demonstrate the proposed method improves the accuracy of target localization during respiratory movement and appeals the potentials applying to clinical application.
Hyperglycemia is related to adverse outcomes in patients with acute ischemic stroke treated by mechanical thrombectomy (MT).
To compare the predictive ability of admission blood glucose (ABG), fasting blood glucose (FBG), and glycated hemoglobin (HbA1c) in patients with acute large vessel occlusion (ALVO) stroke undergoing MT.
The study retrospectively analyzed the data of 329 consecutive acute stroke patients treated by MT. Multivariate logistic regression analysis was performed to investigate the predictors of poor functional outcome. Receiver operating characteristic (ROC) analysis was performed to identify the predictive ability of ABG, FBG, and HbA1c for poor functional independence in patients with ALVO stroke undergoing MT. In addition, subgroup analyses were performed for both diabetic and nondiabetic patients.
Multiple logistic regression analysis demonstrated that ABG and FBG were independent predictors of 3-month poor functional outcome; however, HbA1c could not predict poor functional outcome. Receiver operating characteristic (ROC) analysis showed that FBG has a higher predictive ability than ABG (areas under the ROC curve [AUCs] 0.689 vs. 0.624, P=0.037) and HbA1c (AUCs 0.689 vs. 0.541, P<0.001) for poor function outcome.
ABG and FBG are independent predictors of poor functional outcome in patients with acute ischemic stroke undergoing MT, and FBG has a higher predictive ability than ABG and HbA1c. This article is protected by copyright. All rights reserved.
ABG and FBG are independent predictors of poor functional outcome in patients with acute ischemic stroke undergoing MT, and FBG has a higher predictive ability than ABG and HbA1c. This article is protected by copyright. All rights reserved.
Postoperative pancreatic fistula (POPF) is a potentially lethal complication of pancreatic surgery. POPF rate is consistently higher after distal pancreatectomy (DP) compared with pancreatoduodenectomy (PD). The acinar score of the remnant pancreas is associated with postoperative pancreatitis and POPF. This study aimed to (i) confirm the difference in POPF rate after DP vs PD; (ii) confirm the association between acinar score and POPF; and (iii) evaluate the difference in acinar scores between DP and PD.
Patients undergoing DP or PD at a single institution from 2011 to 2017 were included. Hematoxylin and eosin-stained slides of the pancreatic resection margin were evaluated for all patients and scored for acinar cell density. Clinicopathological data were retrieved from a prospectively maintained database.
Two hundred and ninety-four patients were included in the analysis (206 PD, 88 DP). The POPF rate was significantly higher after DP than PD (20.4% vs 11.2%, P=.043). Acinar score>50 was independently associated with the development of POPF (OR 6.457, P=.003). DP was associated with a higher median acinar score than PD (65 vs 50, P<.001).
The POPF rate is significantly higher after DP compared with PD and is attributable to a higher acinar score of the pancreatic resection margin.
The POPF rate is significantly higher after DP compared with PD and is attributable to a higher acinar score of the pancreatic resection margin.The heme-copper oxidase superfamily comprises cytochrome c and ubiquinol oxidases. Selonsertib ASK inhibitor These enzymes catalyze the transfer of electrons from different electron donors onto molecular oxygen. A B-family cytochrome c oxidase from the hyperthermophilic bacterium Aquifex aeolicus was discovered previously to be able to use both cytochrome c and naphthoquinol as electron donors. Its molecular mechanism as well as the evolutionary significance are yet unknown. Here we solved its 3.4 Å resolution electron cryo-microscopic structure and discovered a novel dimeric structure mediated by subunit I (CoxA2) that would be essential for naphthoquinol binding and oxidation. The unique structural features in both proton and oxygen pathways suggest an evolutionary adaptation of this oxidase to its hyperthermophilic environment. Our results add a new conceptual understanding of structural variation of cytochrome c oxidases in different species.
Global myocardial strain assessments have been shown to provide useful measures of contractility in many diseases, but whether feature tracking (FT)-derived strain at rest can differentiate ischemic myocardium from infarcted and remote myocardium in patients with coronary artery disease (CAD) remains unclear.
To evaluate the performance of magnetic resonance imaging FT-derived strain in the detection of regional myocardial deformation in ischemic, infarcted, and apparent normal myocardium in CAD.
Retrospective POPULATION A total of 109 patients with CAD.
Steady-state free-precession rest cine, T1-weighted saturation-recovery fast gradient echo stress/rest perfusion, and two-dimensional phase-sensitive inversion recovery breath-hold late gadolinium enhancement (LGE) tests were performed at 3.0 T.
Based on perfusion and LGE images, left ventricular (LV) myocardial segments of CAD patients were categorized into ischemic, infarcted, and negative groups. The FT longitudinal (LS) and circumferential straiof CAD patients were higher compared to healthy controls and varied between ischemic, infarcted, and negative segments.
4 TECHNICAL EFFICACY Stage 5.
4 TECHNICAL EFFICACY Stage 5.
