Shieldsbullard1103

Interactions between CpbHLH1 protein and AtPAP1/NtAN2 protein were detected via yeast two-hybrid (Y2H) and bimolecular fluorescence complementation (BiFC) assays. This is the first bHLH repressor of anthocyanin biosynthesis identified in dicotyledons. These results can help us better understand the anthocyanin regulatory network in plants and may provide insights into the diverse functions of bHLH proteins.OBJECTIVES To compare diagnostic performances of current guidelines for the diagnosis of HCC in LT candidates using gadoxetic acid-enhanced liver MRI (Gd-EOB-MRI). METHODS Eighty-one patients (119 HCCs and 35 non-HCCs) who underwent preoperative Gd-EOB-MRI and subsequent LT were included. Per-lesion imaging diagnoses of HCCs were made using four different guidelines (American Association for the Study of Liver Disease (AASLD), European Association for the Study of the Liver (EASL), Asian Pacific Association for the Study of the Liver (APASL), and Korean Liver Cancer Association-National Cancer Center (KLCA-NCC) guidelines, and patient allocation was determined according to Milan criteria (MC). Comparisons of per-lesion sensitivity, specificity, and accuracy of patient allocation between guidelines were performed using logistic regression with generalized estimating equations. RESULTS For diagnosis of HCC, AASLD guideline showed highest specificity (97.4%), followed by EASL and KLCA-NCC guidelines (92.1% and 9 diagnoses of HCCs. • KLCA-NCC more accurately classified patients not appropriate transplantation candidates than EASL.OBJECTIVE To evaluate the use of two alternative picture archiving and communication systems (PACS) interface devices (a graphics tablet and a handheld controller) in clinical practice and on task-oriented exercises. MATERIAL AND METHODS Eleven senior radiologists were prospectively evaluated. The participants used the two tested interface devices for 10 working periods each and answered a questionnaire to evaluate the ergonomics of this experience. The prevalence of work-related musculoskeletal discomfort with the standard PACS interface set (mouse-keyboard-recording device) and these two devices was assessed. Exercises evaluating image scrolling and selection, image zooming and panning, image windowing, performing measurements, and reporting were performed with the standard PACS interface set and with the two tested devices. The sitting posture and hand position were evaluated. RESULTS The general appreciation of the two alternative interface devices was considered to be similar to that of the standard interface set. The ergonomics of the handheld controller was considered to be slightly better than that of the standard interface set. The prevalence of musculoskeletal discomfort was 81%, 45%, and 18% for the standard interface set, graphics tablet, and handheld controller, respectively. With the graphics tablet and the handheld controller in 45% and 60%, respectively, there was a working posture change with respect to the standard interface set. The mean total exercise completion times of both tested devices were 27% higher than that of the standard interface set. CONCLUSION Despite the increase in completion time of the task-oriented exercises, the tested devices were well accepted and considered to be more comfortable than the standard set. KEY POINTS • Alternative PACS interface devices can be used as a substitute for the standard mouse-keyboard-recording device set with a potential improvement in work ergonomics and a reduction in work-related musculoskeletal discomfort.OBJECTIVES To evaluate the feasibility and image quality of respiratory motion-resolved 4D zero echo time (ZTE) lung MRI compared with that of 3D ZTE. METHODS Our institutional review board approved this study. Twenty-one patients underwent lung scans using 3D ZTE and 4D ZTE sequences via prospective and retrospective soft gating techniques, respectively. Image qualities of 3D ZTE and 4D ZTE at end-expiration were compared through objective and subjective assessments. The quality of end-expiratory images of 3D ZTE and 4D ZTE of the two groups with different lung functions was also compared. RESULTS Images were successfully acquired in all patients without any adverse events. Signal-to-noise ratios (SNRs) of lung parenchyma and thoracic structures were significantly (all p  less then  0.001) higher in 4D ZTE. Contrast-to-noise ratios (CNRs) of peripheral bronchi, peripheral pulmonary vessels, and nodules or masses were significantly (all p  less then  0.001) higher in 4D ZTE. The subjective image quality assessed by two independent radiologists showed that intrapulmonary structures, noise and artifacts, and overall acceptability were superior in 4D ZTE (all p  less then  0.001). Image qualities of groups with normal and low lung functions differed significantly (all p  less then  0.05) in 3D ZTE, but not in 4D ZTE. The mean acquisition time was 136 s (127-143 s) in 3D ZTE and 325 s (308-352 s) in 4D ZTE. CONCLUSIONS Respiratory motion-resolved 4D ZTE lung imaging was feasible as part of routine chest MRI. The 4D ZTE provides motion-robust lung parenchymal images with better SNR and CNR than the 3D ZTE, regardless of patients' lung function. KEY POINTS • ZTE MRI captures rapidly decaying transverse magnetization in the lung parenchyma. read more • 4D ZTE provides motion-robust lung parenchymal images with better SNR and CNR compared with 3D ZTE. • Compared with 3D ZTE, the image quality of 4D ZTE lung MRI was affected less by patients' lung function and respiratory performance.The original version of this article, published on 16 December 2019, unfortunately contained two mistakes.OBJECTIVES To validate the performance of an automatic tool to estimate a patient's peak skin dose (PSD) and a skin dose map from data collected by a radiation dose management system (RDMS) during interventional procedures. METHODS In total, 288 eligible consecutive patients undergoing abdominopelvic embolisation or planned coronary angioplasty using radiochromic films were screened between June 2018 and March 2019. For 98 included patients, PSD was measured using radiochromic films (PSDFilm) and computed by RDMS (PSDRDMS) using one flat and two anthropomorphic phantoms. Statistical concordance between PSDFilm and PSDRDMS was computed with Lin's concordance correlation coefficient and clinical concordance with the Bland and Altman graphic; values were compared using the paired Mann-Whitney-Wilcoxon test. RESULTS In total, 190/288 patients were excluded and 98 patients were analysed (69 men, mean age 66 ± 14 years). The PSDFilm median (1st; 3rd quartile) was 0.59 Gy (0.40; 1.08). PSDRDMS was 0.62 Gy (0.43; 1.22) for the flat phantom and 0.