Flemingflowers1976

673, 0.719, and 0.791, at 1-, 3- and 5- years, respectively. Patients with EC were divided into low- or high-risk group by median risk score, and GSEA showed that low-risk group was enriched in adjacent cells communication pathways while high-risk group was involved in metabolism and immune pathways. The nomograms could also help to guide personal prognostic prediction and therapeutic strategies in EC. CONCLUSIONS Our study not only determine 5 ARGs signature that could predict the prognosis of EC but also provide novel insights into the underlying mechanisms of autophagy.

The aim On the basis of literature data, as well as a clinical case study, to assess the state of the problem of abnormal invasion of the placenta in obstetrics at the present stage.

Materials and methods Based on the materials of the world's leading citation databases (MEDLINE, EMBASE, Cochrane), a brief review of the literature data over the past 5 years is presented, dedicated to the issues of abnormal placental invasion. The possibilities of a complex of diagnostic studies and clinical management of women with an anomaly of placenta attachment are considered. A clinical case study of abnormal placental invasion is presented.

Conclusions AIP is an extremely serious condition with not fully understood etiological and pathogenic mechanisms. Correct and timely verification of this pathological condition, based on the simultaneous use of a whole complex of diagnostic studies (history taking, 2D, 3D, energy and color Doppler mapping, MRI), contributes to the development of individual tactics for the management and delivery in women with AIP, making it possible to reduce maternal morbidity and mortality and improve perinatal outcomes.

Conclusions AIP is an extremely serious condition with not fully understood etiological and pathogenic mechanisms. Navarixin order Correct and timely verification of this pathological condition, based on the simultaneous use of a whole complex of diagnostic studies (history taking, 2D, 3D, energy and color Doppler mapping, MRI), contributes to the development of individual tactics for the management and delivery in women with AIP, making it possible to reduce maternal morbidity and mortality and improve perinatal outcomes.

The aim To analyze modern research methods that allow to determine the features of the position of the tongue during the functions of swallowing and speech.

Materials and methods An analysis of 37 literature sources, which contains information about the methods of examination of patients with dento-maxillar anomalies.

Conclusions The functions of the tongue (swallowing and speaking) are very complex and coordinated movements that require the activation of many anatomical structures. Therefore, the disorders of the tongue during swallowing and speech are still considered by scientists as the most difficult in terms of correction and achieving of the long-term and stable results of orthodontic treatment. The study of modern trends in the diagnosis of the state of language functions in terms of understanding the functioning of the dental-maxillary area as a masticatory organ, the work and condition of the components of which depend on many systems of the human body, is relevant. Thus, the emergence of new nderstanding the functioning of the dental-maxillary area as a masticatory organ, the work and condition of the components of which depend on many systems of the human body, is relevant. Thus, the emergence of new and modifications of existing research methods undoubtedly expand the capabilities of modern orthodontists. However, this does not reduce the importance of the clinical stage of examination of patients with disorders of the maxillofacial area, including the functions of the tongue. Therefore, it is necessary to know and understand the advantages and disadvantages of modern and existing research technologies, which will allow to choose a communicatively integrated and differentiated approach to diagnostic issues in each clinical case.Multiple sclerosis (MS) is a chronic autoimmunological condition of the central nervous system (CNS) affecting mainly young adult individuals. The prevalence ranges approximately between 50 and 300 per 100000 individuals. It is characterized by an inflammatory process, demyelination and axonal loss. Immunological mechanisms resulting in the damage to the myelin sheath effecting then in impaired nerve impulse conduction have the key role in MS pathogenesis. The role of inflammatory factors has also been proved. However, it has not been explicitly shown whether such an inflammatory process is the triggering factor or secondary to a yet unknown infectious factor or a degenerative process of the CNS. Therefore, recognition of the epigenetic risk factors, such as geographical latitude, vitamin D level, hygiene hypothesis, Epstein-Barr virus (EBV) infection and others may contribute to better understanding of the mechanism underlying multiple sclerosis. Additionally, they may provide guidelines for more efficient therapies and better prevention of the disease. Aim of this review is to present most current data on multiple sclerosis risk factors, considering those less known.

The aim To investigate the causes of the negative impact of diabetes mellitus co-morbidity on the onset and development of COVID-19 in diabetic patients.

Materials and methods Electronic databases of MEDLINE and Google Scholar were searched using keyword searches.

Conclusions 1. Diabetes mellitus is not a verdict. Diabetic patients can have COVID-19 with the same frequency as other people. And diabetes mellitus co-morbidity does not increase the probability of development COVID-19. 2. Previous diabetes can contribute the complications of COVID-19, patient's severe condition and can increase the mortality. 3. The reasons for the negative results of COVID 19 treatment in patients with diabetes may be features of autonomic innervation in patients with diabetes, impaired function of pancreatic islet cells due to the influence of SARS-CoV-2, use of some cardiac drugs, expression of inflammatory factors due to infection.

Conclusions 1. Diabetes mellitus is not a verdict. Diabetic patients can have COVID-19 with the same frequency as other people.