Buchthorup9505

Smoking (OR 3.505; p = 0.028), non-steroidal anti-inflammatory drugs intake (OR 3.473; p = 0.021) and small intestine bacterial overgrowth (OR 3.172; p = 0.013) were independent risk factors for altered fecal calprotectin in the absence of endoscopic lesions. Cirtuvivint cost No association was found for any of the other variables. CONCLUSIONS smoking and the use of non-steroidal anti-inflammatory drugs are strongly associated with elevated levels of fecal calprotectin in symptomatic patients with a negative colonoscopy and capsule endoscopy of the small bowel. Small intestine bacterial overgrowth is also associated.Transverse myelitis (TM) is a serious inflammatory disorder of the spinal cord. The annual incidence is 1 to 5 cases per million people. It produces sensory, motor and autonomic symptoms. Once metabolic and vascular causes and demyelinating diseases have been ruled out, they can be classified as paraneoplastic, parainfectious (up to half debut after infection), toxic-pharmacological (TNFα receptor inhibitors can induce TM) or associated with systemic diseases (Lupus). After a complete study, up to 30 % are considered idiopathic.OBJECTIVE to assess eating habits, lifestyle, body composition and prevalence of Metabolic Syndrome in menopausal women evaluated according to body mass index. METHODS cross-sectional study (2011-2018) in a cohort of menopausal women residing in Mallorca (n = 555) classified according to body mass index (BMI) less then 27.0, 27.0-29.9 and ≥ 30 kg/m2. Eating habits, toxic and lifestyle, history of breastfeeding and obesity (in childhood, time of evolution and family history) were evaluated. A body composition analysis was performed by electrical bioimpedance and fasting blood was taken for the following parameters glucose, triglycerides, total cholesterol, LDL-cholesterol and HDL-cholesterol. RESULTS the prevalence of overweight grade II was 26.8% and of obesity 46.5%. The prevalence of metabolic syndrome was 41.4%. The family history of obesity, childhood obesity and the time of evolution (≥ 15 years with obesity) were higher in obese women. The practice of regular physical activity was low (63% of women with null and 33% scarce physical activity). Obese women had a higher prevalence of metabolic syndrome (55.8%) and higher values of BMI, abdominal circumference, fat mass, visceral fat, abdominal obesity, blood pressure, glucose and triglycerides in blood, but lower values of HDL-c. CONCLUSIONS the studied menopausal women reflect inadequate dietary habits, sedentary lifestyle and a high prevalence of obesity and metabolic syndrome. The factors associated with this prevalence are family history of obesity, childhood obesity, time of evolution of obesity, sedentary lifestyle, abdominal obesity and visceral location of fat.Tuberous sclerosis complex (TSC) is a rare disease which is characterized by widespread of a variety of benign tumors in multiple organs. Renal angiomyolipomas (AMLs) are the primary cause of morbidity in TSC due to anemia, renal failure or spontaneous bleeding. In contrast, the hepatic involvement is unusual and it is infrequently described in literature.BACKGROUND long noncoding RNAs (lncRNAs) have attracted attention recently. However, many inconsistencies frequently appeared for the early diagnosis of digestive tract cancers (DTCs). We performed this meta-analysis to describe the diagnostic performance of lncRNAs in the discrimination of DTCs. METHODS data were extracted from PubMed, Web of Science, Embase, and Cochrane Library. Their quality was evaluated using the revised Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Such parameters as sensitivity and specificity were included for pooled analyses. The STATA 12.0 and Meta-Disc 1.4 software packages were used to perform the statistical analysis. RESULTS sixty-nine papers were included in this meta-analysis. The pooled analysis of DTCs showed that lncRNAs had a sensitivity of 0.78 and a specificity of 0.80. The area under the summary ROC curve (AUC) was 0.86. For gastric cancer (GC), the pooled sensitivity and specificity were 0.77 (95 % CI 0.72-0.81) and 0.75 (95 % CI 0.71-0.79), respectively, and the AUC was 0.83. For colorectal cancer (CRC), these three parameters were 0.82 (95 % CI 0.76-0.86), 0.84 (95 % CI 0.79-0.88), and 0.90, respectively. For esophageal cancer (EC) sensitivity was 0.74 (95 % CI 0.67-0.80) and specificity reached 0.86 (95 % CI 0.72-0.93), with an AUC of 0.82. CONCLUSIONS LncRNAs show potential diagnostic value for discrimination between DTCs.ereditary Angioedema (HAE) is a rare autosomal-dominant disease caused by serum C1 inhibitor deficiency. This deficiency leads to an up-regulation of complement, activating the bradykinin pathway and causing vascular permeability and subsequent mucosal edema. Abdominal angioedema is a less recognized type of angioedema and the clinical signs may range from subtle, diffuse abdominal pain and nausea, to overt peritonitis. We describe one case of abdominal angioedema in a patient with known HAE that were diagnosed by ultrasound.INTRODUCTION splenomegaly and/or focal splenic lesions (FSL) have limited histopathologic studies due to the risk posed by splenic punctures. Percutaneous biopsies with a fine needle are difficult, especially due to interposition of gases, ascites, obesity or a history of abdominal surgery. On the other hand, endoscopic ultrasound (EUS) takes advantage of the proximity of the gastric wall to the spleen in order to puncture and visualize the needle and its movements in real time. OBJECTIVE to describe the initial experience and results obtained with EUS-FNA in patients with splenomegaly or FSL. MATERIALS AND METHODS this was a descriptive observational study. EUS-FNA of the spleen was performed with a slow-pull technique, which avoided fanning with an average of 3 needle passes. Biopsies were sent in Cytorich RedTM solution for analysis by cytology and cell block. RESULTS punctures were performed in 15 patients (9 females) and the median age was 67 years (range 44-86). Patients studied due to an enlarged spleen or splenic FSL, in the context of fever of an unknown origin, adenopathies and abnormal weight loss were included. A conclusive diagnosis was achieved by EUS-FNA in 10 patients (66.7 %), 4 were large cell type B non-Hodgkin's lymphoma and one Hodgkin's lymphoma. There were no immediate or delayed complications related to the procedure. CONCLUSIONS EUS-guided splenic punctures appear to be safe, effective and may be necessary in some clinical settings in order to complete the etiologic filiation of splenomegaly of an uncertain origin or FSL and to rule out malignancy.