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s can help in early diagnosis, effective management and control of their potential transmission.

The high prevalence of colistin and carbapenem resistant genes, and their co-existence in plasmid DNA of E. coli isolates in this study suggests the possible spread to other animal, human and environmental pathogens. Molecular methods in addition to the conventional diagnostics in laboratories can help in early diagnosis, effective management and control of their potential transmission.The motion analysis of two-finger tip pinching using the thumb and index finger provides crucial data for designing the motion mechanism of electric prosthetic hands. The purpose of this study is to determine the joints that have high mobility during two-finger tip pinching by measuring the flexion angle of each joint. Ten Japanese men with normal hand were selected. CT images were obtained while the hands adopted the following four postures a basic posture not pinching a cylinder, and three postures pinching wooden cylinders with different diameters (2, 10, and 30 mm). selleck Three-dimensional bone models of the thumb and index finger were created using the CT images and used to measure the flexion angles of the joints. The flexion angles of the proximal interphalangeal and metacarpophalangeal joints of the index finger significantly decreased as the diameter of the cylinder increased. However, even when the diameter of the cylinder changed, the flexion angle of the distal interphalangeal joint of the index finger, and the flexion and rotation angles of all of the thumb joints did not change. When pinching objects of different sizes with a two-finger tip pinch, the posture of the thumb is fixed, and only the posture of the index finger changes. When designing the two-finger tip pinch motion for an electric prosthetic hand, it is sufficient to drive the joints of the index finger only.

Diabetic retinopathy (DR) is the leading cause of blindness in many countries. The current treatment for non-proliferative DR (NPDR) using Western medicine (WM) alone is insufficient. At present, the combination of NPDR treatment with traditional Chinese medicine (TCM) and WM is universally applied. We aimed to evaluate the effectiveness and safety of TCM as an add-on for NPDR using a systematic review and meta-analysis.

Data from randomized controlled trials (RCTs) of TCM for NPDR treatment along with WM before July 6, 2019, were collected from the

,

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and

. Relevant data were extracted by two reviewers.



statistics was adopted to appraise heterogeneity. If



 < 50% the fixed-effects model was employed, otherwise a random-effect model was employed. (PROSPERO CRD42019134947).

Eighteen RCTs (1522 patients) were included based on the inclusion and exclusion criteria. The results showed that compared with WM alone, TCM (including Compound Xueshuantong Capsule, Qiming Granule, and others) combined with WM for NPDR could improve the overall effiicacy [n = 1686, RR 1.24 (1.18,1.30),

 < 0.00001,



 = 0%], and reduce the influence of risk factors related to NPDR, such as glycated hemoglobin level [n = 360, MD - 0.85 (- 1.28, - 0.41),

 = 0.0001,



 = 72%], triglyceride (P < 0.00001), and total cholesterol (

 = 0.0008). Moreover, no serious adverse events were reported.

Compared with WM alone, TCM + WM could significantly improve NPDR and also reduce the correlation levels of risk factors, such as hyperglycemia, dyslipidemia. However, the small sample included in the study might lead to a publication bias, and therefore, our results should be treated with caution.

Compared with WM alone, TCM + WM could significantly improve NPDR and also reduce the correlation levels of risk factors, such as hyperglycemia, dyslipidemia. However, the small sample included in the study might lead to a publication bias, and therefore, our results should be treated with caution.

Long noncoding RNAs (lncRNAs) played a crucial role in a number of biological processes. lncRNA HAGLROS was demonstrated to facilitate cell proliferation and migration in various cancers. However, the functions and molecular mechanisms of HAGLROS in osteosarcoma remained to be elucidated.

qRT-PCR assay was used to detect the relative expression of HAGLROS in osteosarcoma tissue samples and cells. CCK-8 and Transwell assays were performed to assess the effects of HAGLROS on OS cells proliferation and invasion. Luciferase reporter assay verified the interaction between ROCK1 and miR-152.

In our study, we found that the expression of HAGLROS increased osteosarcoma samples and cell lines compared with normal tissues and cells. HAGLROS knockdown inhibited certain functions of U2OS and SW1353 cells in vitro. Moreover, HAGLROS depletion inhibited tumor growth and metastasis in vivo. Mechanically, we found that HAGLROS sponged miR-152 to promote ROCK1 expression in U2OS and SW1353 cells.

In summary, our study indicated that HAGLROS could promote osteosarcoma progression by sponging miR-152 to promote ROCK1 expression. The results showed HAGLROS/miR-152/ROCK1 axis might act as a novel therapeutic strategy for osteosarcoma.

In summary, our study indicated that HAGLROS could promote osteosarcoma progression by sponging miR-152 to promote ROCK1 expression. The results showed HAGLROS/miR-152/ROCK1 axis might act as a novel therapeutic strategy for osteosarcoma.Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). It was declared on March 11, 2020, by the World Health Organization as pandemic disease. The disease has neither approved medicine nor vaccine and has made governments and scholars search for drastic measures in combating the pandemic. Regrettably, the spread of the virus and mortality due to COVID-19 has continued to increase daily. Hence, it is imperative to control the spread of the disease particularly using nonpharmacological strategies such as quarantine, isolation, and public health education. This work studied the effect of these different control strategies as time-dependent interventions using mathematical modeling and optimal control approach to ascertain their contributions in the dynamic transmission of COVID-19. The model was proven to have an invariant region and was well-posed. The basic reproduction number and effective reproduction numbers were computed with and without interventions, respectively, and were used to carry out the sensitivity analysis that identified the critical parameters contributing to the spread of COVID-19.