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The second project was a collaboration between VDS and CDC to provide Hispanic people with information about Zika virus infection and health education. The third project is a collaboration between MHUs and the University of Arizona to provide basic health services to Hispanic communities in Pima and Maricopa counties, Arizona. The VDS/MHU model uses a collaborative approach that should be further assessed to better understand its impact on both the US-born and non-US-born Hispanic population and the public at large in locations where it is implemented.Introduction Group iterative multiple model estimation (GIMME) has proven to be a reliable data-driven method to arrive at functional connectivity maps that represent associations between brain regions across time in groups and individuals. 1-Methylnicotinamide However, to date, GIMME has not been able to model time-varying task-related effects. This article introduces HRF-GIMME, an extension of GIMME that enables the modeling of the direct and modulatory effects of a task on functional magnetic resonance imaging data collected by using event-related designs. Critically, hemodynamic response function (HRF)-GIMME incorporates person-specific modeling of the HRF to accommodate known variability in onset delay and shape. Methods After an introduction of the technical aspects of HRF-GIMME, the performance of HRF-GIMME is evaluated via both a simulation study and application to empirical data. The simulation study assesses the sensitivity and specificity of HRF-GIMME by using data simulated from one slow and two rapid event-related designs, and HRF-GIMME is then applied to two empirical data sets from similar designs to evaluate performance in recovering known neural circuitry. Results HRF-GIMME showed high sensitivity and specificity across all simulated conditions, and it performed well in the recovery of expected relations between convolved task vectors and brain regions in both simulated and empirical data, particularly for the slow event-related design. Conclusion Results from simulated and empirical data indicate that HRF-GIMME is a powerful new tool for obtaining directed functional connectivity maps of intrinsic and task-related connections that is able to uncover what is common across the sample as well as crucial individual-level path connections and estimates.
The Responding to Urgency of Need in Palliative Care (RUN-PC) Triage Tool is a novel, evidence-based tool by which specialist palliative care services can manage waiting lists and workflow by prioritising access to care for those patients with the most pressing needs in an equitable, efficient and transparent manner.
This study aimed to establish the intra- and inter-rater reliability, and convergent validity of the RUN-PC Triage Tool and generate recommended response times.
An online survey of palliative care intake officers applying the RUN-PC Triage Tool to a series of 49 real clinical vignettes was assessed against a reference standard a postal survey of expert palliative care clinicians ranking the same vignettes in order of urgency.
Intake officers (
= 28) with a minimum of 2 years palliative care experience and expert clinicians (
= 32) with a minimum of 10 years palliative care experience were recruited from inpatient, hospital consultation and community palliative care services across metropolitan and regional Victoria, Australia.
The RUN-PC Triage Tool has good intra- and inter-rater reliability in inpatient, hospital consultation and community palliative care settings (Intraclass Correlation Coefficients ranged from 0.61 to 0.74), and moderate to good correlation to expert opinion used as a reference standard (Kendall's Tau rank correlation coefficients ranged from 0.68 to 0.83).
The RUN-PC Triage Tool appears to be a reliable and valid tool for the prioritisation of patients referred to specialist inpatient, hospital consultation and community palliative care services.
The RUN-PC Triage Tool appears to be a reliable and valid tool for the prioritisation of patients referred to specialist inpatient, hospital consultation and community palliative care services.
Studies on the appropriate use of urinary catheters for cancer patients at the end of life are limited.
To clarify the differences among institutions in the prevalence of and indications for urinary catheterization of advanced cancer patients at palliative care units.
Pre-planned secondary analysis of a multicenter, prospective cohort study; East-Asian collaborative cross-cultural Study to Elucidate the Dying process (EASED).
This study enrolled consecutive advanced cancer patients admitted to palliative care units between January and December 2017. The final study group comprised 1212 patients from 21 institutions throughout Japan.
Out of the 1212 patients, 380 (31.4%; 95% confidence interval, 28.7%-34.0%) underwent urinary catheterization during their palliative care unit stay, and the prevalence of urinary catheterization in patients who died at palliative care units by institution ranged from 0.0% to 55.4%. When the 21 participating institutions were equally divided into three groups according ts or agitation.
Carers' end-of-life caregiving greatly benefits society but little is known about the monetary value of this care.
Within an end-of-life cancer setting (1) to assess the feasibility and content validity of a post-bereavement measure of hours of care; and (2) to obtain a monetary value of this informal care and identify variation in this value among sub-groups.
A census based cross-sectional survey of all cancer deaths from a 2-week period in England collected detailed data on caregiving activity (10 caregiving tasks and the time spent on each). We descriptively analyse the information carers provided in 'other' tasks to inform content validity. We assigned a monetary value of caregiving via the proxy good method and examined variation in the value via regression analysis.
The majority of carers (89.9%) were able to complete the detailed questions about hours and tasks. Only 153 carers reported engaging in 'other' tasks. The monetary value of caregiving at end-of-life was £948.86 per week with social and emotional support and symptom management tasks representing the largest proportion of this monetary valuation.
