Husumharper1303

Theorists treat liberty as a great equalizer. selleck inhibitor We can't easily distribute equal welfare, but we can purport to distribute equal liberty. In fact, however, nothing about "equal liberty" is meaningfully equal. To demonstrate, I turn not to familiar cases of distributing positive goods but to the distribution of a negative good, namely carceral punishment. Many theorists believe we should impose proportional punishment by depriving offenders of liberty in proportion to their blameworthiness. In this manner, equally blameworthy offenders are said to receive equal punishment when incarcerated for the same period of time. Equal periods of incarceration do not yield equal punishments, however, because liberty cannot serve as the great equalizer theorists hope for. Pretending it can prevents us from justifying the full harms of punishment or leads to such counterintuitive results that it makes proportional punishment an unattractive goal.The COVID-19 pandemic disrupted normalcy for college attending young adults which resulted in a loss of the campus environment and classroom setting. This change in setting may interfere with a student's personal and academic wellbeing. This study used an online survey to evaluate college students' academic and psychosocial frustrations during the COVID-19 pandemic. Data were collected from March-April 2020 at a land-grant university in the Appalachian region. Data were available from 2643 undergraduate and graduate students. There was a 65.8% and 15.7% increase in the number of students who reported their learning and health as fair, poor, or very poor after the COVID-19 pandemic, respectively. Qualitative responses were coded and 8 themes and 24 subthemes emerged. College students expressed frustrations regarding technology, classwork, research, family, social, emotional, behavioral, and financial aspects of life. These results can be used by higher education administration, faculty, and staff when planning for online courses. Ensuring that student frustrations and barriers to success are recognized and considered may help prevent students departing from higher education during this time.The demand for autologous hair transplantation is steadily increasing. The procedure has a low risk for complications with a great benefit for the patients. In order to prevent complaints and legal actions as well as postoperative dissatisfaction of the patients, in addition to the correct performance of the procedure a comprehensive and extensive clarification is necessary in advance. In particular, as a defined specialist standard for the performance of hair transplantation procedures is lacking, the compliance with a formal complete preparation including a thorough and complete informed consent as well as a preoperative consultation are recommended in advance of a planned hair transplantation. In this article tips and guidance are given on how to avoid typical grounds for dissatisfaction and also legal claims on behalf of the patients.Finite mixtures of generalized linear models are commonly fitted by maximum likelihood and the EM algorithm. The estimation process and subsequent inferential and classification procedures can be badly affected by the occurrence of outliers. Actually, contamination in the sample at hand may lead to severely biased fitted components and poor classification accuracy. In order to take into account the potential presence of outliers, a robust fitting strategy is proposed that is based on the weighted likelihood methodology. The technique exhibits a satisfactory behavior in terms of both fitting and classification accuracy, as confirmed by some numerical studies and real data examples.There are many reasons and background factors for conflict including differences in political and social beliefs and values. Wars have also been a threat to the environment and sustainability. Inequality and disparity are more apparent in the world due to COVID-19. Now, we also need to consider environmental changes caused by human activities as climate extremes might cause new conflicts. More studies are needed for a comprehensive understanding of holistic views on challenges at the interfaces of peace and sustainability that inherently involve inter- and trans-disciplinary collaboration among cohorts of communities of practice. Collaborative scientific research on these interfaces is being conducted under the Future Earth Programme, and many others. In this commentary, I posit that science offers an effective pathway and a common platform for engagement and interactions aimed at the nexus of sustainability and peace under global changes.The interlinkages between peace and sustainability are embedded in several international agreements and declarations and recognized by various research studies. However, the characteristics of their bidirectional relationship remain underexamined. Here we scope the complex and multifaceted relationship between peace and sustainability based on an experts workshop held at Hiroshima University in August 2019. The workshop focused on how peace, as a process or a condition, can help or hinder sustainability and vice versa. Relevant environmental, socio-political, and economic and technological considerations highlighted at the workshop were integrated into a co-designed heuristic guide for investigating the peace-sustainability nexus in the context of global change. The proposed guide aims to assist academic and policy researchers in identifying the specific pathways through which peace and sustainability interact when addressing complex challenges. The reinforcing potential of the two will ultimately depend on the governance and management of global transformations.Triple-negative breast cancer (TNBC) is one of the most aggressive and metastatic breast cancer subtypes lacking targeted therapy. Our recent work demonstrated that circulating tumor cell (CTC) clusters and polyclonal metastasis of TNBC are driven by aggregation of CD44+ cancer stem cells (CSC) and associated with an unfavorable prognosis, such as low overall survival. However, there is no existing therapeutic that can specifically block CTC or CSC cluster formation. Methods Using patient-derived xenograft (PDX) models, we established an ex vivo tumor cell clustering assay for a pilot screening of blockade antibodies. After identifying EGFR as a target candidate, we modulated the gene expression and inhibited its kinase activity to determine its functional importance in tumor cell clustering and therapeutic inhibition of lung metastasis. We also examined the molecular regulation network of EGFR and a potential connection to CSC marker CD44 and microRNAs, which regulate CTC clustering. Results We report here that EGFR inhibition successfully blocks circulating CSC (cCSC) clustering and lung metastasis of TNBC.