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038).

In accordance with the present study, only the multiple tract punctures were associated with blood transfusion requirements in PCNL.

In accordance with the present study, only the multiple tract punctures were associated with blood transfusion requirements in PCNL.

The prostate cancer microenvironment is highly immunosuppressive; immune cells stimulated in the periphery by systemic immunotherapies will be rendered inactive once entering this environment. Immunotherapies for prostate cancer need to break this immune tolerance. BAY-876 in vitro We have previously identified interleukin-15 (IL-15) as the only cytokine tested that activates and expands immune cells in the presence of prostate cancer cells. In the current study, we aimed to identify a method of boosting the efficacy of IL-15 in prostate cancer.

We engineered, by conjugation to a myristoylated peptide, a membrane-localising form of IL-15 (cyto-IL-15) and the checkpoint inhibitor antibodies cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death ligand 1 (PD-L1) (cyto-abs) to enable them to bind to cell surfaces by non-specific anchoring to the phospholipid bilayer. The efficacy of these agents was investigated by intratumoral administration either alone (cyto-IL-15 or cyto-abs) or in combination (cyto-combo) in subing novel approach for prostate cancer immunotherapy.

We have demonstrated that intratumoral injection of cyto-IL-15 leads to prostate cancer growth delay, induces tumor necrosis and increases survival. Hence, cytotopic modification in combination with intratumoral injection appears to be a promising novel approach for prostate cancer immunotherapy.Diurnal volume changes is one of the main factors influencing socket fit in transtibial prosthesis and causing pressure problem issues. Embedded bladder liners have been recently a potential approach to deal with this problem. The aim of this technical note was to introduce a new transtibial silicone liner designed based on hybrid socket theory. To make expandability in the liner, an integrated wax structure was constructed over the selected areas of the positive model and then removed after lamination process. In addition, a mechanical system with manual control was designed to fit the liner with the residual limb volume by pumping the water in or out of the liner through connective tubes. The results showed that this new design had high reliability in maintaining identical surface pressures after volume changes in laboratory trials. Therefore, it seems that selective expandability of this liner would accommodate residual limb volume fluctuations without disturbing effect on preliminary pressure pattern.Abscopal effect, a radiobiology term meaning "away from target", was practically unheard of just ten years ago. This effect describes the elimination and cure of a non-treated tumor when another part of the body is irradiated. Successful treatment of cancer in patients with multiple metastatic foci has sporadically been reported. Abscopal effect after radiotherapy has been introduced as the key factor which induced an anticancer response in these metastatic lesions. Moreover, not receiving chemotherapy is reported to have a role in cancer regression after radiotherapy. Given this consideration, it can be hypothesized that standard radiotherapy doses, which usually classified as high-dose, may cause cancer cells to expose or release their sequestered antigens that had been previously masked. Furthermore, radiotherapy can decrease the suppressive effect of regulatory T cells which usually down modulate immune responses against cancers. Moreover, some data show that low dose total-body irradiation (TBI) alone (without standard localized high dose radiotherapy) may cause suppression of distant metastasis of tumor cells. Induction of a "whole body abscopal effect" can be involved in suppression of distant metastasis. Here we discuss whether cancer treatments could be more successful if immune system is boosted, not destroyed by the treatments such as chemotherapy.

Foot pressure assessment systems are widely used to diagnose foot pathologies. The human foot plays an important role in maintaining the biomechanical function of the lower extremities which includes the provision of balance and stabilization of the body during gait.

There are different types of assessment tools with different capabilities which are discussed in detail in this paper. In this project, we introduce a new camera-based pressure distribution estimation system which can give a numerical estimation in addition to giving a visual illustration of pressure distribution of the sole.

In this analytical study we proposed an accurate Foot Print segmentation using hidden Markov Random Field model. In the first step, an image is captured from the traditional Podoscope device. Then, the HMRF-EM image segmentation scheme applies to extract the contacting part of the sole to the ground. Finally, based on a simple calibration method, per mm

, pressure estimates to give an accurate pressure distribution measure.

A significant and usable estimation of foot pressure has been introduced in this article. The main drawback of introduced systems is the low resolution of sensors which is solved using a high resolution camera as a sensor. Another problem is the patchy edge extracted by the systems which is automatically solved in the proposed device using an accurate image segmentation algorithm.

We introduced a camera-based plantar pressure assessment tool which uses HMRF-EM-based method has been explained in more detail which gives a brilliant sole segmentation from the captured images.

We introduced a camera-based plantar pressure assessment tool which uses HMRF-EM-based method has been explained in more detail which gives a brilliant sole segmentation from the captured images.

Compared to other genital cancers, cervical cancer is the most prevalent and the main cause of mortality in females in third-world countries, affected by different factors, including smoking, poor nutritional status, immune-deficiency, long-term use of contraceptives and so on.

The present study was conducted to predict cervical cancer and identify its important predictors using machine learning classification algorithms.

In a cross-sectional study, the data of 145 patients with 23 attributes, which referred to Shohada Hospital Tehran, Iran during 2017-2018, were analyzed by machine learning classification algorithms which included SVM, QUEST, C&R tree, MLP and RBF. The criteria measurement used to evaluate these algorithms included accuracy, sensitivity, specificity and area under the curve (AUC).

The accuracy, sensitivity, specificity and AUC of Quest and C&R tree were, respectively 95.55, 90.48, 100, and 95.20, 95.55, 90.48, 100, and 95.20, those of RBF 95.45, 90.00, 100 and 91.50, those of SVM 93.