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ple who use drugs, a population which experiences elevated risk of COVID-19 infection.

Legalization of recreational cannabis use in Canada has prompted a wide array of new policy decisions to be made at all levels of government. Policies had to be designed and implemented to cover everything from the structure of production, distribution, and retail markets to zoning requirements governing the location of storefronts. Policies concerning price have proven particularly challenging due to a lack of observation data on price sensitivity of cannabis demand and the degree to which users are willing to substitute legal cannabis for illicit cannabis and other drugs.

The most rigorous estimates of demand elasticity to date are derived from a sample of 289 cannabis users in Ontario who completed a hypothetical marijuana purchase task (Amlung & MacKillop, 2019). We calculate the optimal price of legal cannabis given a fixed illicit price based on this demand system for a range of parameters around the point estimates provided.

Our results clearly show a dichotomy between minimizing social harms and maximizing government revenue from legal cannabis net of production costs and social harm. In all cases the social harm minimizing legal price was below the illicit price while the net-revenue-maximizing price was above the illicit price.

The existence of the illicit market must be considered when designing legal cannabis pricing policies as it limits the effectiveness of price increases in controlling demand. Legal cannabis prices in Canada have so far been more consistent with revenue maximization than with minimizing social harms.

The existence of the illicit market must be considered when designing legal cannabis pricing policies as it limits the effectiveness of price increases in controlling demand. Legal cannabis prices in Canada have so far been more consistent with revenue maximization than with minimizing social harms.

Information about short Atrial Fibrillation (AF) episodes can be gathered from the diagnostic records of cardiac implantable electronic devices (CIEDs). CIEDs are not accurate when detecting short arrhythmia episodes. The correlation between mode switching events and AF episodes is significant for long events but prone to errors for short episodes.

Expectation-maximization algorithms are used to estimate the parameters of a mathematical model from a list of AF episodes produced by the CIED. The durations of some of the episodes may be missing. Abnormal mode changes are detected and short episodes are joined into longer events when appropriate. The proposed method does not require that the sensitivity parameters of the device are altered. Post-processing of the data is limited to the detection of false negatives, thus paroxysmal arrhythmia diagnostic evaluations are safer.

A three year-long study was carried out with patients with dual-chamber pacemakers (PM) at the Hospital Universitario Central de Asturias (Spain) between 2012 and 2015. The number of patients in which the proposed algorithm altered the final histogram was 40 out of 76. On average, the algorithm removes 2.79% of episodes shorter than 1min in length and finds that 1% of the previously unaccounted episodes are longer than 30min, of which 16% are longer than 24h.

The method is stable and guarantees that long arrhythmia episodes are never eliminated, and at the same time it is the most similar to the human expert in finding new long episodes.

The method is stable and guarantees that long arrhythmia episodes are never eliminated, and at the same time it is the most similar to the human expert in finding new long episodes.

To compare the prevalence and correlates of overweight (OW) and obesity (OB) between autism spectrum disorder (ASD), intellectual disability (ID), and attention deficit-hyperactivity disorder (ADHD) and to investigate which variables significantly contribute to OW/OB in each group.

Of 267 cases (96 with ASD, 80 with ID, and 91 with ADHD) aged 2-18 years, body mass index (BMI) percentiles, birth weight, food reward usage, weekly screen and physical activity time, and psychotropics used were recorded.

OB (OB + OW) prevalence was 22.9 % (36.4 %) in ASD; 22.5 % (40 %) in ID; and 17.6 % (27.5 %) in ADHD. Although the ADHD group had the highest rate of stimulant usage (χ2 = 69.605, p < 0.001), physical activity attendance (χ2 = 49.751, p < 0.001), and the lowest anti-psychotic (χ2 = 69.142, p < 0.001), and anti-depressant usage (χ2 = 7.219, p < 0.001) than ID/DD or ASD, BMI percentile of the participants did not differ between the groups (H(2) = 1.652, p = 0.43). In hierarchical logistic regression analysis, in ASD, food reward (OR = 4.65, 95 %Cl = 1.25-17.19) and the number of psychotropics used (OR = 2.168, 95 %Cl = 1.07-4.36) were significantly related to the risk of OW/OB. selleck inhibitor In ADHD, each drugs administered and a 1-kilogram elevation in birth weight was associated with a 4.09 and 2.82 increased risk for OW/OB.

OW/OB is prevalent in children with neurodevelopmental disorders regardless of their diagnosis. Our findings showed that food rewards put a higher risk for OW/OB in ASD than administering a psychotropic. It could be better to use other positive reinforcements other than edible ones to prevent OW/OB in these children.

OW/OB is prevalent in children with neurodevelopmental disorders regardless of their diagnosis. Our findings showed that food rewards put a higher risk for OW/OB in ASD than administering a psychotropic. It could be better to use other positive reinforcements other than edible ones to prevent OW/OB in these children.

Parent expectations have an important impact on children's outcomes. Despite a wealth of research on the familial experience of children with disabilities in African countries, very few studies have examined expectations these children's parents hold for them.

This study explores parental expectations for children with intellectual disability, or autism and assesses their perceived importance and likelihood of attainment.

Concept mapping methodology with focus groups comprised of parents of children with intellectual disability or autism were employed.

Results revealed several expectation themes independence, acceptance and inclusion, public awareness, education, governmental assistance, resources, and healthcare. Whereas some expectations were congruent with themes in the broader literature, nuances within themes reflected cultural and societal conditions. Themes unique to each country also emerged, and importance and likelihood ratings revealed some cultural variation across the two countries. Expectations and the value placed on them differ across countries.