Alsmollerup6496

QSAR is well-known for its high and fast throughput screening with good hit rate. The QSAR model building involves, (i) chemogenomics data collection from a database or literature, (ii) Calculation of right descriptors from molecular representation, (iii) establishing a relationship (model) between biological activity & the selected descriptors (iv) application of QSAR model to predict the biological property for the molecules. Therefore, it is desirable to test experimentally the hits obtained by VS. In this mini-review different web-based machine learning tools, techniques of QSAR for VS, successful applications of QSAR based VS leading to the drug discovery and advantages and challenges of this powerful technique were highlighted. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.It is expected that in 2050 there will be more than 20% of senior citizens aged over 60 years worldwide. Nintedanib clinical trial Such alarming statistics require immediate attention to improve the health of the aging population. Since aging is closely related to the loss of antioxidant defense mechanism, this situation will eventually lead to numerous health problems, including fertility reduction. Furthermore, plant extracts were used in traditional medicine as potent antioxidant sources. Despite many experiments had reported the impact of various bioactive compounds on aging or fertility, there is lack of review papers which combine both subjects. In this review, we have collected and discussed various bioactive compounds from 26 different plant species known to affect both longevity and fertility. These compounds including phenolics and terpenes, are mostly involved in the antioxidant defense mechanism of diverse organisms such as rats, mites, fruit flies, roundworms and even rooster. A human clinical trial should be considered in the future to measure the efficacy of these bioactive compounds on human health and longevity. Ultimately, these plant-derived compounds could be developed into health supplements or potential medical drugs to ensure a healthy aging population. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Quinones are a huge class of compounds capable with affluent and captivating chemistry. p-Benzoquinone (pBNZ) or 1,4-Benzoquinone is a quinone compound which is the key structural motif of numerous biologically active molecules including synthetic and natural products that craft interest in its biological exploration to assess their prospective therapeutic implication. It acquires immense therapeutic potential with least side effects based on the different substitutions on this core molecule. This moiety has a marvelous capability to regulate a varied range of different cellular pathways that can be investigated for various selective activities. p-Benzoquinones have been a requisite core for the development of novel therapeutic molecules. In this standalone review, emphasis has been given on the various synthetic and pharmacological approaches along with structure activity relationship studies that emphasized on the chemical groups responsible for evoking the pharmacological potential of p-benzoquinone derivatives. The review is focused on the chemical, pharmaceutical and medicinal aspects of synthetic and natural benzoquinone derivatives that are seen in large classes of important compounds. The natural occurrences of p-benzoquinone derivatives with different pharmacological significance are also reported in this review. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Coumarin has a place with a class of lactones which are fundamentally comprising of a benzene ring fused to αpyrone ring, known as benzopyrones. It likewise has a conjugated framework with electron rich and good charge-transport properties. It is delivered by plants to shield themselves from predation as a chemical response. Despite the fact that, coumarins have been utilized in different products like cosmetics, additives, perfumes, aroma enhancers in various tobaccos and some alcoholic drinks their most relevant role in natural products, organic and medicinal chemistry. Besides, as medicinal candidates a lot of coumarin compounds with strong pharmacological activity and low toxicity and high bioavailability and better curative effects, etc. has been used to treat various types of diseases.Various endeavors have been done to create coumarin-based anticoagulant, antimicrobial, antioxidant, anticancer, anti-diabetic, anti-neurodegenerative, analgesic and anti-inflammatory agents. A class of chemical compounds called as furocoumarins having phototoxic properties found in nature synthesized by plants by fusion of coumarin to a furan ring in different plant species. Psoralens belong to the furocoumarin class which occurs naturally in various plants e.g. lemons, limes, and parsnips. Angelicin is one of the isomers of psoralens and generally most of the furocoumarins are derivatives of psoralens or angelicin. e.g. xanthotoxin, bergapten, and nodekenetin. The present work demonstrated that Psoralen molecules not just have only have anti-tumoral activity against breast cancer yet in addition influence different intracellular signals which maintain high survival of breast cancer cells. Psoralens performs different functions e.g. antagonize metabolic pathways, protease enzymes, cell cycle progression and even interfere in the crosslinking between receptors and growth factor mitogenic signaling. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Andrographolide, a labdane diterpenoid, is extracted and isolated from the plants of Andrographis paniculata. Andrographolide and its derivatives exhibited a wide range of biological properties including anticancer activity, antibacterial activity, hepatoprotective activity, anti-inflammatory activity, antiviral activity, anti-malarial activity, antidiabetic activity, insecticidal activity, etc. As a continuation, this review aims at giving an overview on the update advances (from 2015 to 2018) of andrographolide and it derivatives in regard to bioactivities, mechanisms of action, structural modifications, and structure-activity relationships. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.