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Because studies have suggested that atropine might slow the progression of myopia in children, randomized clinical trials are warranted to understand this potential causal relationship.

To evaluate the efficacy and safety of atropine, 0.01%, eyedrops on slowing myopia progression and axial elongation in Chinese children.

This was a randomized, placebo-controlled, double-masked study. A total of 220 children aged 6 to 12 years with myopia of -1.00 D to -6.00 D in both eyes were enrolled between April 2018 and July 2018 at Beijing Tongren Hospital, Beijing, China. Cycloplegic refraction and axial length were measured at baseline, 6 months, and 12 months. Adverse events were also recorded.

Patients were randomly assigned in a 11 ratio to atropine, 0.01%, or placebo groups to be administered once nightly to both eyes for 1 year.

Mean changes and percentage differences in myopia progression and axial elongation between atropine, 0.01%, or placebo groups.

Of 220 participants, 103 were girls (46.8%), andannot be determined from this trial, these 1-year results, limited by approximately 70% follow-up, suggest that atropine, 0.01%, eyedrops can slow myopia progression and axial elongation in children and warrant future studies to determine longer-term results and potential effects on slowing sight-threatening pathologic changes later in life.

http//www.chictr.org.cn Identifier ChiCTR-IOR-17013898.

http//www.chictr.org.cn Identifier ChiCTR-IOR-17013898.

Parents often provide advice to their adult children during their everyday interactions. This study investigated young adult children's daily experiences with parental advice in U.S. Panobinostat molecular weight families. Specifically, the study examined how receiving advice and evaluations of parental advice were associated with children's life problems, parent-child relationship quality, and daily mood.

Young adult children (aged 18-30; participant N = 152) reported whether they received any advice and perceived any unwanted advice from each parent (parent N = 235) for seven days using a daily diary design (participant-day N = 948). Adult children also reported their positive and negative mood on each interview day.

Results from multilevel models revealed that adult children who reported a more positive relationship with their parents were more likely to receive advice from the parent, whereas adult children who had a more strained relationship with their parents were more likely to perceive advice from the parent as unwanted. Receiving advice from mother was associated with increased positive mood, whereas unwanted advice from any parent was associated with increased negative mood. Further, the link between unwanted advice and negative mood varied by children's life problems and parent-child relationship quality.

Indeed, parental advice is not "the more the better," especially when the advice is unsolicited. This study highlights the importance of perceptions of family support for emerging adults' well-being.

Indeed, parental advice is not "the more the better," especially when the advice is unsolicited. This study highlights the importance of perceptions of family support for emerging adults' well-being.Obesity and overweight in early childhood have detrimental impacts on children's health and development. Changing policy, system and environmental features focused on physical activity and healthy eating behaviors as part of health promotion interventions can play a key role in prevention strategies in early childhood education settings. These types of changes can have broad reach and are often sustained over time, which allows for impact on children who enter the early childhood education setting year after year. However, there is currently a gap between the generation of evidence for health promotion programs and their application into practice. This study used qualitative methods to evaluate intervention-, organizational- and individual-level factors within a dissemination and implementation framework that may be related to the implementation of a health-promoting intervention in early childhood education settings. Intervention-level factors, including feasibility and adaptability, organizational-level factors, including staff and leadership engagement, and individual-level factors, including attitudes, skills and knowledge, were identified as constructs that impacted the successful implementation of the intervention. These findings provide insight into core dissemination and implementation constructs that should be targeted by obesity prevention interventions in early childhood education settings to ensure maximum impact on sustainable behavior change.

Cynical hostility is a cognitive schema according to which people cannot be trusted, and it has associations with individuals' loneliness. The present study takes a dyadic approach to examine whether cynical hostility is related to one's own and their spouse's loneliness. We further explore whether friendship factors serve as a mediator between individuals' and spouses' cynical hostility and loneliness.

We used 2 waves of the Health and Retirement Study (N = 1,065 couples) and Actor-Partner Interdependence Models (APIMs) with mediation to examine the proposed model. Mediation was tested with the construction of path models and significance levels were reached using bootstrapping.

For both husbands and wives, cynical hostility was significantly associated with loneliness. Husband's loneliness was also significantly associated with his wife's cynical hostility, but wife's loneliness was not associated with her husband's cynical hostility. We further found that the association between wife's own cynical hostility and loneliness was mediated by lower levels of contact with, and support from friends. Friendship factors did not serve as mediators for husbands.

Husbands and wives who have higher levels of cynical hostility may be more vulnerable to loneliness. High levels of cynical hostility in women may be related to deficits in their quantity and quality of friendship, and thus be associated with loneliness. Men who are married to women with a higher level of cynical hostility may experience increased loneliness, but this relationship is not explained by men's friendships.

Husbands and wives who have higher levels of cynical hostility may be more vulnerable to loneliness. High levels of cynical hostility in women may be related to deficits in their quantity and quality of friendship, and thus be associated with loneliness. Men who are married to women with a higher level of cynical hostility may experience increased loneliness, but this relationship is not explained by men's friendships.