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Programs that prevent the development of severe problem behavior in young children with autism spectrum disorder (ASD) are critically needed. We describe a program designed to do this, and we report on a preliminary evaluation of its effects with four 3- and 4-year-old children with ASD. Parents served as the primary implementers, with twice-weekly coaching from a Board Certified Behavior Analyst. Direct measures and Aberrant Behavior Checklist scores reflected decreases in emerging problem behavior. Direct measures also reflected increases in child communication, social, and cooperation skills, and parents rated the process as highly acceptable. A randomized controlled trial will be required to evaluate the extent to which the program prevents the development of problem behavior in young children with ASD.

The online version contains supplementary material available at 10.1007/s40617-020-00490-3.

The online version contains supplementary material available at 10.1007/s40617-020-00490-3.We conducted an empirical examination of derived relational responding as a generalized operant and concurrently evaluated the validity and efficacy of program items contained in the Promoting the Emergence of Advanced Knowledge - Equivalence (PEAK-E) curriculum. A first study utilized a multiple-baseline across-skills experimental arrangement to determine the efficacy of equivalence-based instruction guided by PEAK-E, replicated across 11 children with autism. Iclepertin A total of 33 individualized skills were taught, and the subsequent emergence of untrained relations was tested throughout the investigation. The mastery criterion was achieved for 29 of the 33 instructional targets. Additionally, for 3 participants, results were again replicated with a novel set of stimuli. A second study evaluated the degree to which multiple-exemplar equivalence-based instruction led to the emergence of derived relational responding as a generalized operant. The organized nature of the PEAK curriculum allowed the impact on derived relational responding to be compared to that produced by earlier PEAK models that are focused on the direct training of traditional verbal operants. PEAK-E instruction was introduced in a multiple-baseline design across two participants, with a third staying in a training baseline throughout. Increases in derived relational responding using novel, untrained stimuli were only observed when multiple-exemplar equivalence-based instruction was introduced. Taken together, these results provide support for derived relational responding as a generalized operant and demonstrate the utility of conducting larger scale evaluations of higher order behavioral phenomena in single-case experimental arrangements.

In this review, we sought to describe the most recent advances in the dietary and medical management of peanut and tree nut allergy, including selective introduction and immunotherapy.

Dietary updates include changes to labeling laws, improved information sources, and new apps for buying foods in shops and overseas to better protect individuals with nut allergies. There are still issues in the management of nut allergies in schools, such as parents having to resort to packed lunches instead of school meals and patients experiencing bullying. Air travel also poses concern, but additional resources are now available to travelers, and recent evidence suggest limited airborne exposure to nuts. The medical management of anaphylaxis is use of epinephrine; however, this remains underutilized. Needle length and administration devices have been recently debated considering the risk of bone penetration vs subcutaneous administration, and autoinjectors seem to deliver higher peak concentrations than syringes. Selective nut introduction has gained momentum in the last 5 years, demonstrating improved quality of life but with the need for motivated parents for continued consumption and available resources for challenges. Immunotherapy to nuts is also a rapidly developing field, with the balance of efficacy and safety being important considerations in the differing modes of administration.

The management of nut allergies is a rapidly developing field, and dietary and medical management have progressed significantly in the last 5 years. Future research directions include improving safety and efficacy of food immunotherapy and examining patients' goals for therapy and treatment outcomes.

The management of nut allergies is a rapidly developing field, and dietary and medical management have progressed significantly in the last 5 years. Future research directions include improving safety and efficacy of food immunotherapy and examining patients' goals for therapy and treatment outcomes.The lives of human individuals and groups around the globe have changed drastically due to the emergence of novel corona virus in late 2019. The significant part of CoV-19 from the global point is transmission rate, and therefore, it is mandatory to identify and isolate the affected persons even with the mild infection. To stop the rapid transmission of virus to drastic manner, it is essential to follow the hygienic practices, identification of potential vaccines and proper health care management systems to combat the novel virus. Despite the serious mortality rates and high confirmed cases, at present, there is no proven treatment and vaccine to treat the pandemic coronavirus. The current review prioritizes the recent trends in the health care sector, vaccine development pipeline and artificial intelligence role to combat CoV-2. Due to the unprecedented situation, the health care professionals was under high working stress and they were pushed to make serious decisions on time. Several health care workers pose directly threat to the occupational health risk. Besides, the industry is also experiencing a decrease in the outpatient footfalls along with the reduction of international patients. Furthermore, the services such as hypertension, diabetes, cancer and cardiovascular affected by 53%, 49%, 42% and 31%, respectively, due to the pandemic. Vaccines and treatments are the urgent need and have been extensively on progress worldwide. Despite the new technologies, the effectiveness of the old antiviral, such as Chloroquine and hydroxychloroquine, Lopinavir-Ritonavir, Nafamostat and Camostat, and Remdesiviron COVID-19, was reviewed. The reviews on different vaccinations were effective in the understanding the efficiency of drugs in reducing the symptoms of COVID-19. Although vaccination and social distancing can reduce the infection, the role of the Artificial intelligence technology will enable the highest reduction of the COVID-19 infection by reducing the time and increasing the reliability.

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