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CONCLUSIONS Owing to similarities in the decision-making process, patients could be considered as a subgroup of consumers, suggesting that preference elicitation concepts from the consumer field may be relevant in health care. Five concepts that help to simulate real-life decision making have the potential to improve patient preference elicitation. However, the extent to which real decision-making contexts can be mimicked in health care remains unknown. ©Niki Ver Donck, Geert Vander Stichele, Isabelle Huys. Originally published in the Interactive Journal of Medical Research (http//www.i-jmr.org/), 31.03.2020.BACKGROUND AND OBJECTIVES To evaluate the reproducibility and construct validity of the Madras Diabetes Research Foundation FFQ (MDRF-FFQ) with biomarkers for its use in epidemiological settings in India. METHODS AND STUDY DESIGN The MDRF-FFQ was administered to 500 participants representing rural and urban areas of 10 Indian states, twice at an interval of 12 months. Reproducibility was assessed using intra cluster correlation coefficients (ICC). Construct validity of carbohydrate and fat intake was assessed using baseline serum lipids by regression analysis. RESULTS Reproducibility as measured by ICC was 0.50-0.77 for saturated fatty acids (SFA) and energy in urban and 0.61-0.72 for protein and SFA in rural areas. The ICC for food groups was 0.53-0.77 for whole grains, fruits and vegetables in urban and 0.50-0.89 for animal foods and whole grains in rural areas. After adjusting for potential confounders, carbohydrate intake was positively associated with serum triglycerides (TG) (β [SE] +2.3 [0.72] mg/dL; p=0.002) and inversely with high density lipoprotein cholesterol (HDL) (β [SE]-0.48 [0.12], p less then 0.001), while dietary fat and SFA (% Energy) were positively associated with HDL, low density lipoprotein (LDL) and total cholesterol and inversely with TG. CONCLUSIONS The MDRF-FFQ can be considered as a reliable and valid tool to measure the long-term dietary exposure in respect of macronutrient intakes in Indian populations despite diverse dietary practices.BACKGROUND AND OBJECTIVES To evaluate the synergistic and individual associations of leisure-time physical activity (LTPA) intensity and the frequency of milk intake in adulthood with newly diagnosed pathoglycemia. Pathoglycemia comprised impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM). METHODS AND STUDY DESIGN This cross-sectional study of 3977 adults was conducted in Mentougou District, Beijing, China. After excluding ineligible individuals or those with missing data, 2977 participants were included in the final analysis. Data on LTPA, milk intake, and other demographic characteristics were obtained through previously designed questionnaires. Newly diagnosed pathoglycemia was determined based on fasting plasma glucose (FPG) concentration. RESULTS Among all participants, 21.4% had newly diagnosed pathoglycemia, 9.9% engaged in moderate to vigorous leisure-time physical activity (MVLTPA), and 63.7% drank milk more than once weekly. Relative to those who engaged in low-intensity LTPA and drank milk less than once weekly, those who engaged in MVLTPA (OR 0.584, 95%CI 0.410-0.810) and drank milk more than once weekly (OR 0.734, 95% CI 0.614-0.878) had a lower risk of pathoglycemia; this association was greater when both variables interacted (OR 0.446, 95% CI 0.287-0.669). CONCLUSIONS MVLTPA and enough frequency of milk intake synergistically decreased the risk of pathoglycemia. A future interventional study including both factors should be performed.BACKGROUND AND OBJECTIVES The association between circulating vitamin D and liver cancer risk has been controversial on the basis of epidemiological studies. The aim of this study was to quantitatively evaluate this association with prospective studies. METHODS AND STUDY DESIGN A systematic literature search was implemented in PubMed and Scopus databases up to June 2019. Using a random-effects model, the multivariate-adjusted relative risks (RRs) with corresponding 95% confidence interval (CI) were pooled for the highest versus lowest category. Trend estimation was conducted with a two-stage dose-response meta-analysis. RESULTS Six independent prospective studies (992 liver cancer events and 60,811 participants) were included for data synthesis. The summary estimate showed that a higher circulating vitamin D was associated with lower risk of liver cancer (Summary RR=0.78; 95% CI 0.63, 0.95; I2=53.6%, p=0.035). Dose-response analysis indicated that liver cancer was associated with 8% (95% CI 0.89, 0.95) lower risk with a 10 nmol/L increment of circulating vitamin D concentration. CONCLUSIONS The present study provides substantial evidence that a higher concentration of circulating vitamin D would have conferred protection against liver cancer.BACKGROUND AND OBJECTIVES An individual's liking for food maybe associated with food consumption. This study investigates the association between food liking and dietary quality in Australian young adults. METHODS AND STUDY DESIGN Food liking and food frequency data were collected via an online Food Liking Questionnaire (FLQ) and Food Frequency Questionnaire (FFQ). Food liking scores were calculated for groupings of foods. FFQ Food intake data was used to calculate diet quality using a 13 item Dietary Guideline Index (DGI). TTK21 mw The relationship between food liking and DGI was assessed using linear regression models and the difference was assessed using an independent sample t-test and One-way ANOVA. RESULTS Data were available from n=2,535 participants (BMI=24 (SD 3.74), age=21.9 (SD 5.05) years, female=77.1%). Liking for grains, vegetables, fruits, dairy, plant-based protein, was weakly positively associated with diet quality. Liking for animal-based protein, fat and oil, sweet food, and salty food, was weakly negatively associated with diet quality. Liking for grains, vegetables, fruits, dairy, plant-based protein and healthy foods increased across increasing DGI tertiles, and liking for animalbased protein, fat and oil, sweet food, salty food and discretionary foods decreased across increasing DGI tertiles. CONCLUSIONS The results were logical with increased liking for healthy or discretionary foods linked with increased consumption of those foods. The results reinforce the strategy to introduce a variety of healthy food groups early in life to initiate flavour-nutrient learning and increase liking for healthy foods.

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