Merrillhussain7464
To address the biomarkers that correlated with the prognosis of patients with PDCA using bioinformatics analysis.
The raw data of genes were obtained from the Gene Expression Omnibus. We screened differently expressed genes (DEGs) by Rstudio. Database for Annotation, Visualization and Intergrated Discovery was used to investigate their biological function by Gene Ontology(GO) and Kyoto Encyclopedia of Genes (KEGG) analysis. Protein-protein interaction of these DEGs were analyzed based on the Search Tool for the Retrieval of Interacting Genes database (STRING) and visualized by Cytoscape. Genes calculated by Cyto-Hubba with degree >10 were identified as hub genes. Then, the identified hub genes were verified by UALCAN online analysis tool to evaluate the prognostic value in PDCA.
Three expression profiles (GSE15471, GSE16515 and GSE32676) were downloaded from GEO database. The three sets of DEGs exhibited an intersection consisting of 223 genes (214 upregulated DEGs and 9 downregulated DEGs). GO analysis showed that the 223 DEGs were significantly enriched in extracellular exosome, plasma membrane and extracellular space. ECM-receptor interaction, PI3K-Akt signaling pathway and Focal adhesion were the most significantly enriched pathway according to KEGG analysis. By combining the results of Cytohubba, 30 hub genes with a high degree of connectivity were picked out. Finally, we candidated 3 biomarkers by UALCAN online survival analysis, including CEP55, ANLN and PRC1.
we identified CEP55, ANLN and PRC1 may be the potential biomarkers and therapeutic targets of PDCA, which used for prognostic assessment and scheme selection.
we identified CEP55, ANLN and PRC1 may be the potential biomarkers and therapeutic targets of PDCA, which used for prognostic assessment and scheme selection.
Despite the available diagnostics and treatment, tuberculosis (TB) is a serious infectious disease currently occurring. Even some high-income countries in the world do not fully control it at this time. 2-DG solubility dmso The reason for this situation is the lack of elimination programs to address the situation. The aim of the update of the prediction data was to create a presumption of TB development in Slovakia by 2040.
We used the time series prediction method with exponential equalization. The basis for the calculation were historical data on the incidence of TB from 1960 to 2018 in Slovakia (data for the last 58 yr). This time series has a clearly declining level. In view of this trend, we have set a threshold, whether and when the incidence in the future will fall below 5.0 patients per 100,000 inhabitants.
In case of a favorable development, the limit of our incidence drop below 5.0 cases per 100 000 inhabitants in 2022, when the incidence will be 4.91 per 100 000 inhabitants. In 2040, the predicted incidence of TB should be 1.78 per 100 000 inhabitants. A gradual decline may also be related to a decrease in the population of the Slovak Republic.
Slovakia belongs to those countries of the world where TB is under control. Increased surveillance of high-risk communities through community interventions and countries' readiness for global migration can help to influence factors that may aggravate the epidemiological situation of TB.
Slovakia belongs to those countries of the world where TB is under control. Increased surveillance of high-risk communities through community interventions and countries' readiness for global migration can help to influence factors that may aggravate the epidemiological situation of TB.
Judges may experience mental health problems, which reduces their performance in juridical cases, and constitutes a great threat to both the authority of law and social justice. This study aimed to assess the prevalence of psychological distress among judges and examine the effect of perfectionism on psychological distress with age and gender as the moderators.
This survey was carried out in person with 565 Chinese judges in 2016, using the Almost Perfect Scale-Revised and the Kessler Psychological Distress Scale. The effects of perfectionism on psychological distress was explored by Structural Equation Model (SEM), and the moderating effects of age and gender were tested by Multi-group analysis.
Psychological distress was reported by 89.20% of the judges surveyed. Discrepancy had a significant positive effect on psychological distress, but order had a significant negative effect on psychological distress, with high standards exerting no significant effect. Age had a significant moderating effect, whereas the moderating effect of gender was not significant.
The three dimensions of perfectionism exerted different effects on psychological distress of Chinese judges, and the relationships were moderated by age.
The three dimensions of perfectionism exerted different effects on psychological distress of Chinese judges, and the relationships were moderated by age.
We aimed to examine the effects of cool-down exercise and cold-water immersion therapy on agility, speed, power, balance, and sport-specific skill performance in college soccer players, and to provide baseline data for the development of effective recovery programs.
In August 2020, 21 male college soccer players in Seoul, Korea, were randomly divided into the following groups control group (CG, n=7), cool-down exercise group (CDG, n=7), and cool-down exercise plus cold-water immersion group (CDCWG, n=7). Agility, speed, power, balance, and sport-specific skill performance were assessed before and after the intervention.
No significant differences in Southeast Missouri (SEMO) Agility Test, 20-m sprint test, vertical jump test, or Y-balance test (right) were observed among the groups; however, there was a significant effect of time (
<0.05) and a significant time × group interaction (
<0.05). Significant effects of time (
<0.001), group (
=0.043), and a time × group interaction (
=0.009) were observed in the Y-balance test (left). There were no between-group differences in the 22-m dribble test, shooting test (left), or shooting test (right); however, there were significant effects of time (
<0.05) and significant time × group interactions (
<0.05). No significant effects of group or time × group interactions were observed for the kicking test (left or right); however, there were significant effects of time (
<0.001).
Addition of cold-water immersion therapy to a recovery program including cool-down exercise can promote recovery of basic and sport-specific abilities among college soccer players.
Addition of cold-water immersion therapy to a recovery program including cool-down exercise can promote recovery of basic and sport-specific abilities among college soccer players.
Given the long-term impact of public health emergencies on adolescents' mental health, extensive effort should be exerted in the psychological intervention of adolescents during the COVID-19 pandemic. This study combined solution-focused theory and video health education to explore the intervention effect of this model on adolescents' mental health.
Overall, 126 volunteers with anxiety symptoms from four communities in 2021 in Anhui Province, China were randomly divided into the intervention and control groups (63 members in each group). The control group only received health education popularized in the community. By contrast, the intervention group was given the same health education and provided with solution-focused psychological counseling and short video health education related to the pandemic.
Results after the intervention were as follows 1) The Self-rating Anxiety Scale scores of both groups were low, but the effect on the intervention group was better than the control group (
< 0.05). 2) Both groups' positive and negative affect scores were higher and lower than those before the intervention were, but changes in the scores of the intervention group were greater than that of the control group (
< 0.05).
The group intervention of solution-focused theory combined with video health education can improve the mental health level of adolescents, effectively alleviate their anxiety and negative emotions, and improve their positive emotions.
The group intervention of solution-focused theory combined with video health education can improve the mental health level of adolescents, effectively alleviate their anxiety and negative emotions, and improve their positive emotions.
We aimed to investigate the efficacy of Shenqi Jiangtang granules-assisted Western medicine in the treatment of gestational diabetes mellitus (GDM).
A total of 147 patients with GDM treated in Qilu Hospital of Shandong University from Jan 2018 to Apr 2019 were enrolled. They were randomly divided into traditional Chinese medicine (TCM) combined with Western medicine group, Western medicine group and control group. The control group was treated with exercise combined with diet therapy, and the Western medicine group was additionally treated with metformin tablets. The TCM combined with Western medicine group was additionally treated with Shenqi Jiangtang granules.
After treatment, the levels of 10 indicators in the three groups were lower than those before treatment (
< 0.05). These indicators were the lowest in the TCM combined with Western medicine group. However, high-density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) after treatment increased in the three groups compared with those before treatment (
< 0.05), which was the most obvious in the TCM combined with Western medicine group. After treatment, the number of patients with natural delivery in the TCM combined with Western medicine group was the largest. The incidences of complications in pregnant women, fetuses and newborns were the lowest in the TCM combined with Western medicine group.
Application of Shenqi Jiangtang granules-assisted Western medicine in patients with GDM can effectively control blood glucose and lipid levels, enhance antioxidant capacity, reduce the levels of inflammatory cytokines and decrease the incidence of adverse pregnancy outcomes.
Application of Shenqi Jiangtang granules-assisted Western medicine in patients with GDM can effectively control blood glucose and lipid levels, enhance antioxidant capacity, reduce the levels of inflammatory cytokines and decrease the incidence of adverse pregnancy outcomes.
This cross sectional study was conducted to analyse the level of motivation and prosocial as well as antisocial behaviors of the individuals with physical disabilities who do sports, to evaluate whether their motivational states were related with prosocial and antisocial behaviors, and to determine if the type of disability affect their motivation or prosocial and antisocial behaviors.
The research was conducted on 688 individuals who do sports and have physical disabilities in various regions of Turkey in 2020. Motivation Scale for Sports Participation of People with Disabilities (MSSPPD), Pro-social and Antisocial Behavior in Sport Scale (PABSS) were used as data collection tools in this research.
Motivation to participate in sports level of the individuals with physical disabilities was quite high. Their prosocial behavior towards their teammates and opponents was high, while their antisocial behavior towards teammates and opponent team players was low. When subjects' motivations were examined according to the type of disability, motivation levels of individuals with orthopedic and visual disabilities were higher than those of individuals with hearing disabilities.
