Randolphmcintyre2874

Our findings emphasize the importance of attending to key contextual barriers in coordinating care for rural veterans, and they illustrate the value of fundamental structural and relational approaches to enhancing such care coordination.Background This study aimed to translate the original version of the CAITY into a Thai version by using cross-cultural adaptation and to examine the psychometric properties and cut-off score of the CAITY Thai version (CAITY-T). Methods Six steps of cross-cultural adaptation were used to translate and validate the psychometric properties in 267 participants (140 with CAI; 127 without CAI; mean age = 12.3 ± 2.42 years). Validation was carried out for internal consistency, concurrent validity against a visual analog scale for global perceived ankle instability, and discriminative validity (ROC curve). CAITY-T was completed twice by 133 volunteer children (49.62%) for test-retest reliability. The cut-off score was determined by means of Youden's index. Results CAITY was successfully adapted for the Thai language. Validation showed good internal consistency (Cronbach's alpha = 0.767) and concurrent validity (Pearson correlation coefficient = 0.8 right ankle and 0.784 left ankle). The test-retest reliability was substantial with the ICC (2,1) of 0.865 (95% CI = 0.809 - 0.904). The ROC curve and Youden's index showed the cut-off score that discriminated between children with and without CAI on the CAITY-T at ≤ 25. CAITY-T obtained 95.2% sensitivity, 97% specificity, 0.05 negative, and 32 positive likelihood ratios. Conclusion CAITY-T was valid and available for Thai children aged 8-16 years. It displayed positive reliability, good validity and an acceptable cut-off score for the CAITY Thai version. The cut-off score for children had high sensitivity, specificity, and positive and negative likelihood ratios.Butyric anhydride (BA) is used as an effective functional additive to improve the electrochemical performance of high voltage LiNi 0.5 Mn 1.5 O 4 (LNMO) cathode. In presence of 0.5 wt.% BA, the capacity retention of LNMO/Li cell is significantly improved from 15.3 % to 88.4 % after 200 cycles at 1 C. Furthermore, the rate performance of LNMO/Li cell is also effectively enhanced and the capacity is up to 112 m Ah g -1 even at 5 C, which is considerably higher than that LNMO/Li cell in electrolyte without BA additive (95.4 m Ah g -1 at 5 C). Linear sweep voltammetry and cyclic voltammetry results reveal that the BA additive can be preferentially oxidized to construct a stable cathode electrolyte interphase (CEI) film upon the LNMO cathode. Subsequently, the BA-derived CEI film can alleviate the decomposition of the electrolyte and the dissolution of Mn and Ni ions from LNMO cathode as well as maintain the structural stability of LNMO cathode during the cycling process, which leads to outstanding electrochemical performance. Therefore, this work provides an effective and low-cost functional electrolyte for high-voltage LNMO-based LIBs.Purpose Social support (SS) has been shown to moderate the relationship between psychological distress and physical activity (PA) in adults, including those with no history of cancer and cancer survivors (CS). The purpose of this study was to explore the relationship between stress and leisure-time PA and test if SS is a moderator of this relationship in rural CS. Methods CS were recruited to Partnering to Prevent and Control Cancer (PPCC) and completed questionnaires assessing sociodemographics, leisure-time PA, perceived stress, and SS. Hierarchical multivariable linear regression was used to assess the moderating role of SS on the association between stress and PA. Findings Cancer survivors (N = 219) were in their mid-60s (M age = 64.3 ± 12.5 years) and overweight/obese (M BMI = 29.5 ± 6.8 kg/m2 ); over half were women (60.7%) and insufficiently active (59.4%); and 42.1% reported moderate-to-high perceived stress. Perceived stress was negatively correlated with PA (r = -.183, P = .044) and SS (r = -.470, P less then .001), and SS was positively correlated with PA (r = .205, P = .025). However, SS did not moderate the association between stress and PA. Conclusions Rural CS reported higher stress and less PA than previously reported by urban CS, potentially contributing to rural cancer health disparities. Although previous studies have shown success in building SS to reduce stress and promote PA in CS, our results do not support the stress-buffering hypothesis in rural cancer survivors. Further research is needed to understand factors related to PA in rural CS and determine strategies to reduce psychological distress and promote healthy behaviors in an effort to improve cancer survivorship.Objectives To investigate family members' prioritisation of care in residential aged care facilities (RACFs). Introduction and background Family members are often involved in the care of their older relatives even after these relatives transit to a RACF. Understanding family members' priorities regarding care (i.e., what is most important to them) can provide valuable insights into how to better meet residents' needs. Design A multisite mixed-methods study comprising qualitative methods and Q methodology. The qualitative component of the study was guided by the COREQ checklist. Methods Participants comprised 27 family members of residents living in one of five participating Australian RACFs. Participants rank-ordered 34 cards, each representing an aspect of care, on a predefined grid from "Least important" (-4) to "Most important" (+4). Participants also engaged in a think-aloud task, demographic questionnaire, post-sorting interview and semi-structured interview. Q data were analysed using inverted factor teude flexibility of routines, supporting family members' involvement in care, workforce training focused on family-staff communication, and safer staffing ratios.The aim of this perspective is to give an overlook on the utility of pharmacokinetics/pharmacodynamics (PK/PD) in predicting the efficacy of antifungals in invasive candidiasis. Overall, from the available literature it appears that bridging data of PK/PD of antifungals from the laboratory to the clinic for the treatment of invasive candidiasis are feasible only partially. HPPE Fluconazole is the only antifungal agent having the pharmacodynamic threshold of efficacy identified in experimental animal models convincingly validated in the clinical setting of invasive candidiasis as well. Conversely, for voriconazole and posaconazole data on this topic are very limited. For the echinocandins, robust PK/PD identified in the laboratory represented the rationale for defining differential clinical breakpoints of echinocandins against different species of Candida by the regulatory agencies. However, translation of the findings in the clinical setting provided conflicting results. Data on PK/PD of amphotericin B and flucytosine in models of invasive candidiasis are quite limited, and clinical studies assessing the role of drug exposure on efficacy are currently lacking.