Patelowery4368

The nuclear receptor-related 1 protein, Nurr1, is a transcription factor critical for the development and maintenance of dopamine-producing neurons in the substantia nigra pars compacta, a cell population that progressively loses the ability to make dopamine and degenerates in Parkinson's disease. Recently, we demonstrated that Nurr1 binds directly to and is regulated by the endogenous dopamine metabolite 5,6-dihydroxyindole (DHI). Unfortunately, DHI is an unstable compound, and thus a poor tool for studying Nurr1 function. see more Here, we report that 5-chloroindole, an unreactive analog of DHI, binds directly to the Nurr1 ligand binding domain with micromolar affinity and stimulates the activity of Nurr1, including the transcription of genes governing the synthesis and packaging of dopamine.Fluorinated carbon (CFx) cathodes have the highest theoretical energy density among lithium primary batteries. However, it is still a huge challenge to be reversible. Here, CFx is proposed as a high-performance cathode material for rechargeable lithium-ion batteries in the extended voltage window of 0.5-4.8 V. Specifically, the fluorinated graphite CF0.88 exhibits an initial specific discharge capacity of 1382 mAh g-1 (2362 Wh kg-1) and a specific discharge capacity of 782 mAh g-1 at the 2nd cycle and maintains a specific discharge capacity of 543 mAh g-1 (508 Wh kg-1) after the 20th cycle. This rechargeable behavior is associated with the conversion of CFx to LiF + C (>1.5 V) and then to Li1+xFC (0.5-1.5 V) during the initial discharge process; Li1+xFC is reversible to LiF + C in the following charge-discharge process (0.5-4.8 V). By extending the voltage window, CFx cathodes can show new electrochemical behaviors. Our research has provided new Li-free cathode materials for rechargeable batteries and insights for improving the performance of a Li/CFx secondary battery.ConspectusZeolites, accompanied by their initial discovery as natural mines and the subsequent large-scale commercial production, have played indispensable roles in various fields such as petroleum refining and the chemical industry. Understanding the characteristics of zeolites, in contrast to their counterparts with similar chemical compositions and the origin thereof, is always a hot and challenging topic. Zeolites are known as intrinsic confined systems with ordered channels on the molecular scale, and structural confinement has been proposed to explain the unique chemical behaviors of zeolites. Generally, the channels of zeolites can regulate the diffusion of molecules, leading to a visible difference in molecular transportation and the ultimate shape-selective catalysis. On the other hand, the local electric field within the zeolite channels or cages can act on the guest molecules and change their energy levels. Confinement can be simply interpreted from both spatial and electronic issues; however, the zeolites for adsorption and catalysis.Nitrooxy organosulfates derived from terpenes (NOSTP) represent an important class of products formed between anthropogenic pollution (e.g., SO2 and NOx) and natural emissions. NOSTP compounds have been consistently detected in atmospheric environments under varying urban influences. Their chemical linkages to both anthroposphere and biosphere make them valuable markers for tracking anthroposphere-biosphere interactions. However, their quantification, formation, and transformation kinetics in atmospheric aerosols are hindered due to the lack of NOSTP standards. In this work, we developed two routes for the first concise chemical synthesis of eight NOSTP from terpenes including α-pinene, β-pinene, limonene, limonaketone, and β-caryophyllene. Subsequently, six of the synthesized NOSTP were for the first time positively identified in ambient aerosol samples, clarifying certain misidentifications in previous studies. More significantly, the availability of authentic standards allows irrefutable observation of three carbon skeleton-rearranged NOSTP, two derived from α-pinene, and one derived from β-caryophyllene, revealing the occurrence of previously unrecognized transformation pathways in the formation of NOSTP. Two synthesized NOSTP from β-pinene and limonene could not be detected, likely due to rapid hydrolysis of their immediate hydroxynitrate precursors outcompeting sulfation. Such mechanistic evidence is valuable in understanding the atmospheric chemistry of NOSTP and related compounds. This work demonstrates the usefulness of authentic standards in probing the NOSTP formation mechanisms in the atmosphere. Comparison of NOSTP ambient samples collected from four Chinese cities in two winter months indicates that anthropogenic chemical factors could outcompete terpene emissions in the formation of NOSTP.Electromagnetic wave (EMW)-absorbing materials have a great impact on civil use and national defense. In this paper, a novel composite, RGO@6CoTe2-300 (the mass ratio of reduced graphene oxide to CoTe2 is 16, annealed at 300 °C), has been obtained through a facile melt-diffusion method and solvothermal method. The as-prepared samples have shown excellent reflection losses (RL) and effective adsorption bandwidth (EAB) by controlling the loading of CoTe2 and the annealing temperature. The sample has exhibited a RL of -62.2 dB at 13.04 GHz with the matching thickness of 3.53 mm, and the EAB reaches 8.2 GHz at 2-18 GHz. Moreover, excellent terahertz (THz) absorption property is also obtained at 0.2-2.0 THz. A RL of 54.07 dB is acquired, and the EAB covers 100% of the entire measured bandwidth. Thus, RGO@6CoTe2-300 can be considered as a promising EMW absorption material in both gigahertz and terahertz band ranges.Gold-assisted mechanical exfoliation currently represents a promising method to separate ultralarge (centimeter scale) transition metal dichalcogenide (TMD) monolayers (1L) with excellent electronic and optical properties from the parent van der Waals (vdW) crystals. The strong interaction between Au and chalcogen atoms is key to achieving this nearly perfect 1L exfoliation yield. On the other hand, it may significantly affect the doping and strain of 1L TMDs in contact with Au. In this paper, we systematically investigated the morphology, strain, doping, and electrical properties of large area 1L MoS2 exfoliated on ultraflat Au films (0.16-0.21 nm roughness) and finally transferred to an insulating Al2O3 substrate. Raman mapping and correlative analysis of the E' and A1' peak positions revealed a moderate tensile strain (ε ≈ 0.2%) and p-type doping (n ≈ -0.25 × 1013 cm-2) of 1L MoS2 in contact with Au. Nanoscale resolution current mapping and current-voltage (I-V) measurements by conductive atomic force microscopy (C-AFM) showed direct tunneling across the 1L MoS2 on Au, with a broad distribution of tunneling barrier values (ΦB from 0.