Buurvinding9588

We aimed to investigate the association of plasma cobalt with newly diagnosed type 2 diabetes (T2D) and further explore the potential interaction effects between cobalt and several redox metals, such as manganese, copper and selenium.

A large case-control study including 4564 subjects was conducted. LY2228820 manufacturer 2282 cases with newly diagnosed T2D and 2282 controls were matched by sex and age. The concentrations of cobalt and other metals in plasma were detected with inductively coupled plasma mass spectrometry (ICPMS).

The medians of the cobalt concentrations in plasma were 1.68μg/dL for controls and T2D. There was a U-shaped relation between T2D and plasma cobalt, which was categorized into quartiles. After multivariable adjusted for the confounding factors, the odds ratios (ORs) of T2D across quartiles were 1.22 (95% CI 1.01, 1.46), 1.12 (95% CI 0.94, 1.35), 1.00 (reference) and 1.46 (95% CI 1.22, 1.75), respectively. The association was almost consistent in subgroup analyses. According to the restricted cubic spline analysis, the lowest ORs of T2D was observed at the plasma cobalt of 2.00μg/dL. There was a significant interaction between plasma cobalt and copper (P<0.01). The ORs of T2D in those with medium concentration of plasma cobalt and copper was the lowest.

Higher or lower concentrations of plasma cobalt were related to higher ORs of T2D. The inter-relationship among redox metals in T2D should be further investigated.

Higher or lower concentrations of plasma cobalt were related to higher ORs of T2D. The inter-relationship among redox metals in T2D should be further investigated.Earthworms are known to reclaim soil contamination and maintain soil health. In the present study, the concentration of DTPA extractable heavy metals, Cd, Cu, Cr, Pb, and Zn in vermicasts and tissues of the earthworms (anecic Lampito mauritii; epigeic Drawida sulcata) collected from the soils of four different industrial sites, Site-I (Sago industry), Site-II (Chemplast industry), Site-III (Dairy industry) and Site-IV (Dye industry) have been studied. The heavy metals in industrial soils recorded were 0.01-326.42 mg kg-1 with higher Cu, Cr, and Zn contents while the vermicasts showed lower heavy metal loads with improved physicochemical properties and elevated humic substances. The higher humic substances dramatically decreased the heavy metals in the soil. The bioaccumulation factors of heavy metals (mg kg-1) are in the order Zn (54.50) > Cu (17.43) > Cr (4.54) > Pb (2.24) > Cd (2.12). The greatest amount of metallothionein protein (nmol g-1) was recorded in earthworms from Site-IV (386.76) followed by Site-III (322.14), Site-II (245.82), and Site-I (232.21). Drawida sulcata can produce a considerable amount of metallothionein protein than Lampito mauritii as the metallothionein production is dependent upon the presence of pollutants. The molecular docking analysis indicates a binding score of 980 for Cd, Cr and Cu, and 372 for Zn. Pb may bind with a non-metallothionein protein of earthworms and bio-accumulated in the internal chloragogenous tissues. Metallothionein neutralizes the metal toxicity and controls the ingestion of essential elements.The stenohaline zebra mussel, Dreissena polymorpha, is uniquely sensitive to the ionic composition of its aquatic environment. Waterborne copper (Cu) uptake and accumulation in zebra mussels were examined at various conditions in an environmentally relevant range in freshwater, i.e. Cu exposure levels (nominal concentrations of 25 and 50 μg/L), pH (5.8-8.3), and sodium (Na+) concentrations (up to 4.0 mM). Copper accumulation was simulated by a kinetic model covering two compartments, the gills and the remaining tissues. The Cu uptake rate constant decreased with decreasing pH from 8.3 down to 6.5, indicating interactions between H+ and Cu at uptake sites. The kinetic simulation showed dose-dependent effects of Na+ on Cu uptake. At 25 μg/L Cu, addition of Na+ at 0.5 mM significantly inhibited the Cu uptake rate, while no significant differences were found in the uptake rate upon further addition of Na+ up to a concentration of 4.0 mM. At 50 μg/L Cu, the Cu uptake rate was not influenced by Na+ addition. Calibration results exhibited dose-dependent elimination rates with more profound elimination with increasing exposure levels. With kinetic parameters calibrated at environmentally relevant conditions, in terms of pH and Na+ concentrations, the model performed well in predicting Cu accumulation based on independent data sets. Estimates of the Cu concentration in mussels were within a factor of 2 of the measurements. This demonstrates potential application of kinetic models that are calibrated in environmentally relevant freshwater conditions.Nutrient enrichment in water bodies, and its detrimental consequences, are a well known and worldwide environmental problem. Agricultural activities are identified as an important source of diffuse losses of phosphate and nitrate because of the leaching out fertilizers from agricultural fields. This study encompasses the implementation of an end-of-pipe treatment by capturing phosphate from greenhouse effluent, using granular iron-coated sand (ICS) in an adsorption process. ICS is evaluated as a low-cost by-product because of its adsorption capacity and kinetics. The Langmuir isotherm was suitable for describing the adsorption thermodynamics. The adsorption capacity at an equilibrium concentration Ce of 25 mg PO4-P/L ranged between 1.85 and 3.07 mg PO4-P/g sorbent. Furthermore, both the pseudo-second-order model (R2 = 0.9823) and the Elovich model (R2 = 0.9803) showed a good fit with the kinetic data over the time range investigated, indicating that chemisorption is the rate-limiting step controlling the adsorption process. Higher adsorption capacities were observed at lower initial pH. Continuous bench-scale column experiments were performed to verify the adsorption potential of a filter bed under flow-through conditions, and the experimental data were fit to the Bohart-Adams model. Additionally, a discontinuous feeding regime of the column, resulting in intermediate resting periods, was introduced and showed an enhanced adsorption efficiency over a longer period. Finally, a pilot-scale experiment showed the potential of the ICS for the removal of phosphate from greenhouse effluent. The adsorption process, moreover, enables the recovery of phosphate via efficient desorption.