Bentleygissel4853

The utility of Tb3+Mn4+Na4Mg(WO4)3 phosphors as ratiometric luminescent thermometers in the 200-450 K temperature range is demonstrated. Targeted substitution of Tb3+ for Na+ and Mn4+ for Mg2+ yields phosphors of formula Na4-12xTb4xMg1-2yMn y (WO4)3. UV excitation of the Na4Mg(WO4)3 host results in green emission from terbium (544 nm) and red emission from manganese (682 nm). Differential thermal quenching of these emissions renders Na3.976Tb0.008Mg0.990Mn0.005(WO4)3 thermochromic between 78 and 450 K, with an orange-to-green color change that is particularly noticeable above 200 K. As a result, this phosphor serves as a ratiometric and colorimetric thermometer between 200 and 450 K. Quantitative assessment of its performance yields a maximum relative sensitivity of 2.5 × 10-2 K-1 at 375 K, along with a resolution of 0.5 K and a repeatability of 98%. These findings highlight the versatility of Na4Mg(WO4)3 as a platform to realize luminescent thermometers via targeted aliovalent substitutions.It remains a big challenge to develop HDAC inhibitors effective for solid tumors. Previous studies have suggested that the feedback activation of JAK-STAT3 pathway represents a key mechanism leading to resistance to HDAC inhibitors in breast cancer, suggesting the therapeutic promise of JAK/HDAC dual inhibitors. In this work, we discovered a series of pyrrolo[2,3-d]pyrimidine-based derivatives as potent JAK and HDAC dual inhibitors. Especially, compounds 15d and 15h potently inhibited JAK1/2/3 and HDAC1/6 and displayed antiproliferative and proapoptotic activities in triple-negative breast cancer cell lines. Besides, compounds 15d and 15h also diminished the activation of LIFR-JAK-STAT signaling triggered by tumor-associated fibroblasts, which suggests that these compounds could potentially overcome the drug resistance caused by the tumor microenvironment. More importantly, compound 15d effectively inhibited the tumor growth in MDA-MB-231 xenograft tumor model. Overall, this work provides valuable leads and novel antitumor mechanisms for the treatment of the SAHA-resistant triple-negative breast cancers.The reactions of the pyridine-functionalized silylene LNSi [L = PhC(NtBu)2; N = 2-(methylamido)pyridine] with zinc and cadmium halides are described. These resulted in the formation of a series of zinc and cadmium silylene complexes [LNSi-ZnX2] (X = Cl, Br, I) and [LNSi-CdI22], which is the first cadmium silylene compound. Subsequent reaction of these silylene complexes with elemental sulfur and selenium under mild conditions at room temperature afforded under activation of these elements the corresponding silanethione-stabilized zinc [(LNSi═S)-ZnX2] (X = Cl, I) and cadmium [(LNSi═S)-CdI2] complexes and the silaneselenone-stabilized zinc species [(LNSi═Se)-ZnCl2]. A selective insertion of the group 16 elements into the M-Si bond of the silylenes was observed. Because of metal coordination, the Si-chalcogen bond lengths in the silanethiones and silaneselenones are enlarged and thus range between a single and a double bond. All new compounds were fully characterized by single-crystal X-ray diffraction analyses, multinuclear NMR spectroscopy, elemental analyses, and IR spectroscopy.Hollow mesoporous silica nanoparticles (HMSNs) served as nanocarriers for transporting doxorubicin hydrochloride (DOX) and indocyanine green (ICG) and were incorporated into a pH-sensitive targeted drug delivery system (DDS). Boronate ester bonds were employed to link HMSNs and dopamine-modified hyaluronic acid (DA-HA), which acted as both the "gatekeeper" and targeting agents (HMSNs-B-HA). GO-203 mouse Well-dispersed HMSNs-B-HA with a diameter of about 170 nm was successfully constructed. The conclusion was drawn from the in vitro drug release experiment that ICG and DOX (ID) co-loaded nanoparticles (ID@HMSNs-B-HA) with high drug loading efficiency could sustain drug release under acidic conditions. More importantly, in vitro cell experiments perfectly showed that ID@HMSNs-B-HA could well inhibit murine mammary carcinoma (4T1) cells via chemotherapy combined with photodynamic therapy and accurately target 4 T1 cells. In summary, all test results sufficiently demonstrated that the prepared ID@HMSNs-B-HA was a promising nano-DDS for cancer photodynamic combined with chemotherapy.The outbreak of novel coronavirus SARS-CoV-2 has caused a worldwide threat to public health. COVID-19 patients with SARS-CoV-2 infection can develop clinical symptoms that are often confused with the infections of other respiratory pathogens. Sensitive and specific detection of SARS-CoV-2 with the ability to discriminate from other viruses is urgently needed for COVID-19 diagnosis. Herein, we streamlined a highly efficient CRISPR-Cas12a-based nucleic acid detection platform, termed Cas12a-linked beam unlocking reaction (CALIBURN). We show that CALIBURN could detect SARS-CoV-2 and other coronaviruses and influenza viruses with little cross-reactivity. Importantly, CALIBURN allowed accurate diagnosis of clinical samples with extremely low viral loads, which is a major obstacle for the clinical applications of existing CRISPR diagnostic platforms. When tested on the specimens from SARS-CoV-2-positive and negative donors, CALIBURN exhibited 73.0% positive and 19.0% presumptive positive rates and 100% specificity. Moreover, unlike existing CRISPR detection methods that were mainly restricted to respiratory specimens, CALIBURN displayed consistent performance across both respiratory and nonrespiratory specimens, suggesting its broad specimen compatibility. Finally, using a mouse model of SARS-CoV-2 infection, we demonstrated that CALIBURN allowed detection of coexisting pathogens without cross-reactivity from a single tissue specimen. Our results suggest that CALIBURN can serve as a versatile platform for the diagnosis of COVID-19 and other respiratory infectious diseases.Glycopolymers that can mimic natural glycosaminoglycan, such as heparin, have shown great potentials in inhibition of cancer metastasis. In the current work, a novel series of brush-like glycopolymers (BGPs) with simultaneous functionalization of various monosaccharide or disaccharide compositions have been synthesized through a new grafting-polymerization strategy, in order to mimic the activities of both heparin and P-selectin ligand PSGL-1. In the subsequent in vitro assays of antiadhesion, platelets activation, heparanase inhibition, and so on, BGP-SFH, as one of the BGPs with the composition of the combined three sugar units, sialic acids, fucoses, and heparin disaccharides, showed the highest antimetastasis ability, similar to its prototype heparin. Moreover, in a mouse metastatic melanoma model, the BGP-SFH also inhibited B16 cell metastasis effectively. Thus, the current work not only demonstrated a type of promising antimetastasis glycopolymer BGPs, but also illustrated an easy synthetic approach to multifunctionalized glycopolymers, leading to potential applications for broader biomedical research.