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Migrainous infarction is a complication of migraine that accounts for 0.5-1.5% of all cerebral infarcts, usually seen in the posterior circulation and in young women. In this case report, we report a case of a right-sided middle cerebral artery ischemic stroke in a young male presenting with migraine, photophobia and phonophobia lasting for more than 60 minutes and followed by ipsilateral hemiparesis, which is a very unusual presentation. The provisional diagnosis of ischemic infarction of the right middle cerebral artery was made that was confirmed on radio imaging. A high index of suspicion is always required while dealing with patients with migraine especially in atypical presentations as in this case.Diabetes mellitus is a major risk factor for vascular complications and mortality, glycemic variability (GV) has emerged as a measure of time and magnitude of plasma glucose, its association with cardiovascular complications is controversial. The current study aimed to assess the association of GV with myocardial infarction. An electronic literature search was conducted in PubMed, Medline, and Google Scholar databases for relevant articles. Articles in the English language during the period from 2010 to April 2020 were eligible. The keywords fasting blood glucose variability (FBGV), glucose variability, myocardial infarction, and acute coronary syndrome, were used with the protean OR and AND. Out of the 185 articles retrieved, only seven full texts fulfilled the inclusion and exclusion criteria. The author's name, year of publication, the study type, number of patients, and the results were extracted. There were seven full texts, one from Brazil, one from Australia, two from the USA, and three from Asia. Two were randomized controlled trials and five were prospective cohorts (included 109,058 participants). A significant negative association was found between GV and myocardial infarction, odd ratio (OD) 1.93, 95% CI=1.08-3.44, P-value=0.03, I2 for heterogeneity=87%, P-value=0.0001. However, it is difficult to reach a conclusion due to the small number of the included studies and the high heterogeneity observed. Further well-controlled trials using the same methods are needed to resolve the issue.

The purpose of this study was to investigate cone function deterioration in patients with retinitis pigmentosa (RP) using full field electroretinogram (ffERG), pattern electroretinogram (pERG), and optical coherence tomography (OCT) and their correlation with visual acuity (VA).

Clinical records (2008-2018) of patients with RP undergoing repeat electrophysiology were reviewed. Results of ffERG (30 Hz flicker and fused flicker amplitude [FFAmp]), pERG [p50 and n95], and macular OCT (ellipsoid zone [EZ] and outer segment thickness) were collected.

One hundred twenty-six eyes from 63 patients (33 women, mean age 35 years) were included. The mean decline in VA was 0.11 ± 0.14 logarithm of minimum angle of resolution (logMAR). The FFAmp decreased by 3.01 ± 5.9 µV with global cone function deteriorating by 18.7% annually. The percentage change in FFAmp (RE [

= 0.553], LE [

= 0.531]), and 30 Hz flicker amplitude (RE [

= 0.615], LE [

= 0.529]) strongly correlated with VA (

< 0.00001). The pERG p50 (15 and 30degrees) change analyzed in 34 patients showed reduction by 23% and 23.4%, respectively. The percentage change in p50 30degrees (

= 0.397) correlated with VA and EZ layer (

< 0.05). The EZ layer change was calculated in 45 patients and the shortening and thinning rate was 4.3% and 4.4% annually, respectively. The EZ length percentage change correlated with VA (RE [

= 0.34] and LE [

= 0.466;

< 0.05).

We quantified the decline in cone function in patients with RP utilizing ffERG and FFAmp measures of residual cone function. These parameters correlated with VA and OCT when measurable. These objective measures may assist in monitoring disease progression.

Residual cone function provides an objective estimate of residual visual function, which aids in counselling patients regarding prognosis.

Residual cone function provides an objective estimate of residual visual function, which aids in counselling patients regarding prognosis.

To determine optimal display positions during heads-up surgery (HUS) to minimize crosstalk.

Three three-dimensional (3D) displays were analyzed to evaluate the relationship between display position and amount of crosstalk. First, the 3D displays were calibrated to show a completely white image in the right eye and completely black image in the left eye. Images were captured through the polarized filter, which corresponded to the left-eye image. The amount of crosstalk in the left eye was measured as white areas on the black background that originated from the right-eye image. The amount of crosstalk was measured at different display distances and heights to estimate the non-crosstalk display positions for each display.

Varying amounts of crosstalk (0%-70.3%) were observed for different display distances and heights. The crosstalk almost always started from the corner of the display, although the starting area varied according to the type of display. The minimum distance of non-crosstalk position was 1.26 meters away from display 1, 1.24 meters away from display 2, and 1.8 meters away from display 3. With regard to display height, the optimal center-of-display heights for displays 1, 2, and 3 were 72 mm below, 18 mm above, and 101 mm above eye level, respectively.

The amount of crosstalk differed according to display positions and displays.

The optimal HUS display settings differ among displays; therefore, each surgeon should carefully evaluate individual display characteristics before using HUS in practice.

The optimal HUS display settings differ among displays; therefore, each surgeon should carefully evaluate individual display characteristics before using HUS in practice.

Age-related macular degeneration (AMD) can result in severe vision loss and blurriness in the older population. The early and intermediate stages of AMD typically start without noticeable symptoms and can only be detected with a comprehensive eye exam. click here Because of the quiet onset of the disease, it is necessary to identify potential biomarkers to aid in the diagnosis, staging, and association with disease onset. Inflammasome signaling proteins are prominent biomarkers in the central nervous system, and the inflammasome has been shown to play a role in the innate inflammatory response in aging and AMD.

Serum from healthy controls and AMD patients were analyzed for the protein levels of Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), interleukin (IL)-18 and C-reactive protein (CRP) to determine cutoff points, positive and negative predictive values, and receiver operator characteristic curves, as well as univariate and multivariate linear and logistic regression models.

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