Haytruelsen5481

Background The Apolipoprotein-related MORtality RISk (AMORIS) study in Sweden revealed that serum uric acid (SUA) was significantly associated with hepatobiliary cancer occurrence. However, the association with postoperative hepatocellular carcinoma (HCC) recurrence has not been reported.Methods A total of 256 surgically resected HCC patients were included (from January 2003 to December 2017) in this study. Comparisons in terms of clinicopathologic factors and long-term outcomes were made between patients with high SUA (>6.1 mg/dl) at the time of hepatectomy and low SUA. Besides, SUA data at one postoperative year (1POY) of the same cohort were collected and analyzed in the same manner.Results About 88.8% of tumor relapse sites were the remnant liver. High SUA levels were associated with male and well-differentiated HCCs. Recurrence-free survival (RFS) of high SUA patients was significantly inferior to low SUA patients [median survival time (MST) 22.7 vs. 28.5 mo, P = 0.033], whereas no difference was observed in overall survival (MST both not reached, P = 0.771). RFS of high SUA patients at 1POY also showed significantly poorer outcomes than low SUA patients (MST 29.3 vs. 57.0 mo, P = 0.049).Conclusions High SUA implies a significant risk factor of activating hepatocarcinogenesis. Keeping the SUA level low may be recommended after HCC resections.Heavy metals (HMs) in soil, air, and water environments effect human health. These HMs cannot be degraded in soil and they can only be transformed from one state to another. Food and energy resources such as coal, oil, petrol, etc. are gradually diminishing due to ever increasing demand and consumption, world faces crisis. There is an urgent need to address these problems by reclaiming the waste/polluted land for food and energy production. Various physicochemical remediation strategies are being proposed, developed, and tested but they are all very costly and only applicable to small contaminated sites. During the past two decades or so, plant-based phytoremediation technology is rapidly evolving as a promising new tool to address the issue with the potential to remediate HM contaminated soils in a sustainable manner. Plants, labeled as phyto-tolerant or phyto-accumulators, surviving on such contaminated soils reduce the toxicity by preventing their translocation or destroying the contaminants by sequestratinanotechnology, AMF and PGPR technologies can be merged together to form an integrated nano-mycorrhizo-phytoremediation (NMPR) strategy which synergistically achieve the goal of remediation of soil contaminants and improve the phytoremediation performance of bioenergy plants grown on HM polluted soils. This review also identifies the urgent need to conduct field-scale application of this strategy and use it as potential tool for reestablishing plant cover and population diversity during restoration of derelict land post-industrial/mining activities.Background Self-care behaviours are important to improve health outcomes in patients with heart failure. However, little is known about the factors related to the subdimensions of self-care behaviours in these patients. click here Aims To identify the factors associated with the subdimensions of self-care behaviours among South Korean patients with heart failure. Methods The participants in this cross-sectional descriptive study conducted between October 2016 and January 2017 were 178 patients with heart failure. Self-care behaviours were measured using the EHFScB-9, which has three subdimensions autonomy-based adherence; provider-directed adherence; and consulting behaviours. Demographic characteristics, experience of heart failure education, physical function, patient health questionnaire-9, Pittsburgh sleep quality index and self-care confidence were also measured. Descriptive statistics and multiple linear regression analysis were conducted. Results The mean age was 62 ± 12 years, and 37% were women. Younger age (P=0.023), no experience of heart failure education (P=0.039), poor physical function (P=0.003), poor sleep quality (P=0.037) and lower self-care confidence (P=0.001) were significantly associated with poor autonomy-based adherence. Being unemployed (P=0.042), poor sleep quality (P=0.042) and lower levels of self-care confidence (P=0.001) were associated with poor provider-directed adherence. Younger age (P=0.001) and lower self-care confidence (P=0.001) were associated with lower engagement in consulting behaviours. Conclusion The three subdimensions of self-care behaviours were associated with different psychosocial factors, necessitating the development of tailored interventions and educational materials based on unique self-care behaviour patterns in patients with heart failure.Xenometabolites from microbial and plant sources are thought to confer beneficial, as well as deleterious, effects on host physiology. Studies determining absorption and tissue uptake of xenometabolites are limited. We utilized a conscious catheterized pig model to evaluate inter-organ flux of annotated known and suspected xenometabolites, derivatives, and bile acids. Female pigs (n=12; 2-3 months old; 25.6 ± 2.2 kg) had surgically-implanted catheters across portal-drained viscera (PDV), splanchnic area (SPL), liver, kidney, and hindquarter muscle. Overnight fasted arterial and venous plasma was collected simultaneously in a conscious state and stored at -80°C. Thawed samples were analyzed by liquid chromatography-mass spectrometry. Plasma flow was determined with para-aminohippuric acid dilution technology and used to calculate net organ balance for each metabolite. Significant organ uptake or release was determined if net balance differed from zero. A total of 48 metabolites were identified in plasma, and 31 of these had at least one tissue with a significant net release or uptake. All bile acids, indole-3-acetic acid, indole-3-arylic acid, and hydrocinnamic acid were released from the intestine and taken up by the liver. Indole-3-carboxaldehyde, p-cresol glucuronide, 4-hydroxyphenyllactic acid, dodecanendioic acid, and phenylacetylglycine were also released from the intestines. Liver or kidney uptake was noted for indole-3-acetylglycine, p-cresol glucuronide, atrolactic acid, and dodecanedioic acid. Indole-3-carboxaldehyde, atrolactic acid, and dodecanedioic acids showed net release from skeletal muscle. The results confirm gastrointestinal origins for several known xenometabolites in an in vivo overnight-fasted conscious pig model, while non-gut net release of other putative xenometabolites suggests a more complex metabolism.