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4% ID/g) and HSA-Tt-[99mTc-HyNic] (4.6% ID/g) was detected at 24 h postinjection. In vivo treatment studies were performed in the same HER2(+) breast cancer model using PET-SPECT image guidance. The increased tumor uptake of the pretargeting and drug delivery components was detected by PET-CT and SPECT-CT, respectively. The study showed a significant 92% reduction of the relative tumor volume in treated mice (RTV = 0.08 in 26 days), compared to the untreated control mice (RTV = 1.78 in 11 days) and to mice treated with only HSA-DM1-Tt-[99mTc-HyNic] (RTV = 1.88 in 16 days). Multimodality PET-SPECT image-guided and pretargeted drug delivery can be utilized to maximize efficacy, predict therapeutic response, and minimize systemic toxicity.High operating temperature and low response restrict the application of H2S sensors. Due to the strong chemical affinity of CuO to H2S and the large band gap and high stability of β-In2S3, CuO nanotube/In2S3 nanosheet p/n heterostructures have been delicately designed for binder-free gas sensors by a facile method consisting of sputtering, chemical etching, and annealing. A switching effect of H2S concentration on the response of CuO/In2S3 gas sensors has been observed. When exposed to low-concentration H2S (1-10 ppm), the response is less than 0.10 and dominated by the surface-type adsorption-desorption process between CuO and H2S. When exposed to high-concentration H2S, the sensor exhibits a superior response of 3511 toward 50 ppm H2S, considerable selectivity, and long-term stability at room temperature. This dramatically enhanced response can be explained by the transformed junction from the CuO/In2S3 heterojunction to the CuS/In2S3 Schottky junction. These results suggest that the binder-free ceramic tube-type CuO/In2S3 gas sensor with considerable performance will have promising potential for H2S gas detection. Moreover, this method provides an effective strategy to fabricate other binder-free gas sensors.In this paper, the first demonstration of direct ultratrace determination of lead in a single human hair by direct current-atmospheric pressure glow discharge-atomic emission spectrometry (DC-APGD-AES) coupled with electromagnetic heating vaporization (EMV) was described. Only the ultramicro mass of a human hair sample (about 0.15 mg, often a single human hair) was required during the analysis, and fast detection was implemented without tedious pretreatment processes, such as grinding and digestion. A limit of detection (LOD) of 30.8 μg kg-1 (4.8 pg) for Pb was obtained under optimized conditions, which was even equivalent to that of conventional LA-ICP-MS/ETV-ICP-MS/GFAAS. EMV-APGD-AES, meanwhile, can facilitate miniaturization and portability with low power and small size. The accuracy and practicality of the method were verified by the analysis of certified reference materials (CRMs) GBW09101b (human hair) and human hair samples from three volunteers. A simple, efficient, and low-cost method for detecting Pb in human hair has been developed.

Sexual dysfunction can adversely affect the quality of life and interpersonal relationships. nowadays, a lot of attention is paid to traditional Chinese medicine with better curative effects and less adverse events. Recent studies have implied the promising effect of acupuncture on sexual function. This systematic review evaluate the effectiveness and safety of acupuncture in treating female and male sexual dysfunction.

PubMed, Cochrane Central of Controlled Trials (CENTRAL), EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Scopus, and Google Scholar were searched up to 2021. No limitation to language and date. The methodological quality of the studies was assessed using the Mixed Methods Appraisal Tool (MMAT).

Among 160 initially assessed papers, 13 articles were included. The findings showed that acupuncture improve sexual dysfunction in domains of desire, libido, erectile dysfunction and impotency. Most studies did not report any serious side effects from acupuncture, and only three studies reported minor adverse events.

The available evidence indicate that acupuncture has positive on improvement of sexual dysfunction with no serious side effects. Although acupuncture has gained increasing popularity for the management of sexual dysfunction, high methodological quality evidence regarding its efficacy is lacking.

The available evidence indicate that acupuncture has positive on improvement of sexual dysfunction with no serious side effects. Although acupuncture has gained increasing popularity for the management of sexual dysfunction, high methodological quality evidence regarding its efficacy is lacking.

To compare the effect of oral

and vitamin E on sperm parameters in idiopathic infertile men.

In this triple-blind randomized controlled trial study, fifty 20-45-year-old infertile men with idiopathic abnormal sperm parameters were selected among men referring to the infertility clinic of Al Zahra-Iran Hospital, and randomly allocated into two groups. The first group received

capsules, 500mg, and the second group received vitamin E capsules three times a day for 90days. The primary outcomes of this study were the sperm parameters (count, motility, and morphology).

After the intervention, the mean of sperm count increased from 49.08 to 60.22 million/mL in the

vs. it increased from 47.64 to 58.88 million/mL in the vitamin E group (adjusted mean difference (aMD)=1.124 million/ml, 95% CI-12.892 to 15.141). The mean sperm motility increased from 45.90 to 52.90% in the

group but decreased from 55.23 to 38.10% in the vitamin E group (aMD=17.22%, 95% CI 8.53 to 25.92). The mean sperms with normal morphology increased from 11.52 to 67.05% in the

, and from 10.20 to 77.47% in the vitamin E group (aMD=-10.88%, 95% CI-22.30 to 0.536). There was no serious side effect during the treatment course.

Taking 1,500mg oral dose of

capsule per day for 90days improved sperm motility but had no significant effect for improving morphology and count comparing to vitamin E capsule.

Taking 1,500 mg oral dose of Carob capsule per day for 90 days improved sperm motility but had no significant effect for improving morphology and count comparing to vitamin E capsule.

The long-term consequences of COVID-19 survivors care and post-coronavirus infection are not yet well understood. The review aims to see whether homoeopathy can help COVID-19 survivors recover from its consequences and improve their quality of life.

A systematic search of published articles for post-COVID sequelae and the impact of Homoeopathy were conducted. For the literature search, the major electronic bio-medical database PubMed/MEDLINE was used. In addition, supplementary searches were conducted through the references of those published articles.

A total of 113 records were identified of which 61 studies included for this review. Homoeopathy is effective in the treatment of mental disorders including anxiety and depressive disorder (ADD), some research studies have found, although systematic reviews disagree. Likewise, some medical societies denounce homoeopathy for pain management; other literature shows that it can be used to treat pain effectively. Homoeopathy can aid in the treatment of cardioanagement may be included as part of the follow-up route and as much data as possible in the context of homoeopathy should be collected, so that in future, the role of homoeopathy in dealing with it can be better demonstrated.

To examine the effects of moderate intensity resistance training with blood flow restriction on muscle strength and forearm girth.

Total of 39 students enrolled in this study were divided into three groups that is group A (control group), group B and group C. Group A performed exercise training without restrictive pressure, group B & C performed exercise training with 50 and 75mmHg respectively. Both the outcome measures were evaluated on day 1 and day 12th with the help of digital dynamometer and measuring tape.

Repeated measure ANOVA with Post hoc analysis was done using SPSS software version 20. The result of the study showed significant (p≤0.05) within subject improvement in muscle strength and muscle girth in all the three groups. However, significant improvement in muscle strength was found in between group analysis (p≤0.05).

The results of the study can be concluded as the partial blood flow restriction (50mmHg) with moderate intensity resistance training resulted in greater handgrip strength than the other two groups. No difference was found in forearm girth among the three groups, however within the group difference was found.

The results of the study can be concluded as the partial blood flow restriction (50 mmHg) with moderate intensity resistance training resulted in greater handgrip strength than the other two groups. No difference was found in forearm girth among the three groups, however within the group difference was found.

The appreciative inquiry (AI) interview follows a specific format and needs to be planned and developed before implementation. AI questions are designed to draw on the interviewee's experiences, commencing with general questioning and progressing to more focused questioning.

To explain how to plan and undertake AI interviews, and to discuss issues that nurse researchers might encounter.

This article is based on the first author's experience of undertaking an AI doctoral study. The primary method of collecting data for the study was AI interviews. The more focused questioning related to participants' experiences of positive actions or behaviours. Although questioning was positive in nature and participant-centric, conducting the interviews was more problematic than the first author anticipated. Nuciferine cell line Some participants struggled to recall positive memories to share.

The unexpected response to the interview questions required the first author to examine her practices, as well as beliefs and judgements relating to AI. This reflexivity assisted in implementing changes to the study's process, resulting in a more positive experience for her and the participants.

Researchers using the AI interview require the capacity to be self-critical and change the process if necessary to enrich the outcome.

Researchers using the AI interview require the capacity to be self-critical and change the process if necessary to enrich the outcome.Hereditary tyrosinemia type Ⅰ (HT-1) is a severe autosomal recessive inherited metabolic disease. Due to the deficiency of fumarylacetoacetase hydrolase (FAH), the toxic metabolites are accumulated in the body, resulting in severe liver dysfunction, renal tubular dysfunctions, neurological crises, and the increased risk of hepatocellular carcinoma. Clinical symptoms typically begin at after the birth; the prognosis of patients is poor if they are not treated timely. Succinylacetone is a specific and sensitive marker for HT-1, and the screening in newborns can make early diagnosis of HT-1 at the asymptomatic stage. The diagnosis of HT-1 can be confirmed based on the characteristic biochemical findings and molecular testing of mutations in both alleles of gene. Combined treatment with nitisinone and a low tyrosine diet may significantly improve outcomes for patients. Liver transplantation is an effective treatment in cases where nitisinone is not available. Some novel HT-1 treatments are in clinical trials, including enzyme replacement therapy, hepatocyte transplantation and gene-targeted therapy.