Carstensglass9587

Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. We present primary completion analysis from RIVETING, an ongoing, double-blind, randomized, parallel-group trial evaluating efficacy and safety of tofacitinib dose reduction to 5mg twice daily [BID] versus remaining on 10mg BID in patients in stable remission on tofacitinib 10mg BID maintenance therapy.

Patients had received tofacitinib 10mg BID for ≥2 consecutive years and been in stable remission for ≥6 months before enrollment. The primary endpoint was modified Mayo score remission at month 6. Safety was assessed up to February 20, 2020 [data cut-off].

140 patients were randomized [11] to tofacitinib 5 or 10mg BID; 77.1% and 90.0% of patients in the 5 and 10mg BID groups, respectively, were in modified Mayo score remission at month 6 [adjusted difference 12.9%; 95% CI 0.5-25.0]. Smaller differences between treatment groups were seen in patients with baseline endoscopic subscore of 0 versus 1 [9.8%; Fi failure were more likely to maintain remission. Efficacy data were limited to the first 6-months; a longer duration of follow-up during RIVETING will further characterize the impact of dose reduction on maintenance of remission. Safety findings were consistent with the established safety profile of tofacitinib.People with intellectual and developmental disabilities (IDD) with more severe impairments often face service disparities. The aim of this study was to explore not only disparities in quality of life outcomes for people with IDD with severe impairments, but also disparities in the supports they receive from disability service organizations. Our analysis of Personal Outcome Measures interviews from 1,300 people revealed people with severe impairments experienced quality of life disparities in most domains, attributed to the fact that they also received fewer organizational supports than people with less severe impairments. By paying attention to person-centered outcomes, including these disparities, organizations' roles can shift from just providing services to supporting people to achieve the outcomes that are truly important to them.Social entrepreneurship is a growing trend for people with intellectual disability (ID). This trend reflects a shift in contemporary policy towards entrepreneurship and self-employment as a viable employment option for people with disability in general; a strategy which is intended to promote autonomy and reduce dependence on entitlement-based services as well as to reduce employment disparities and stimulate business and job creation. However, it is not well understood what exactly this means for people with ID involved in social entrepreneurial ventures. This research approached the issue by conducting dyadic interviews to explore the motivations of people with ID who are participating and supported in social entrepreneurship-"why they act." In exploring these motivations, this article investigates push-pull factors, the role of the social mission, and how support influences motivation.The purpose of this study was to investigate the extent to which extracurricular activities are included in Individualized Education Programs (IEPs) of secondary age students with intellectual disability (ID). Student characteristics (grade, disability, use of augmentative and alternative communication) were examined to explore potential group differences. Participants were 498 special education teachers who had at least one student with ID on their caseload who had participated in a school sponsored extracurricular activity. Data were collected through an online questionnaire sent to members of a national listserv for transition professionals. Findings reveal that 63.69% (n = 314) of teachers reported they included information about extracurricular activities in the IEP; however, only 59.61% (n = 186) of these teachers also reported their student worked on IEP goals during extracurricular activities. Student characteristics were related to the presence of extracurricular activities in the IEP, number of IEP goals students worked on during extracurricular activities, student's most important IEP goal, and whether students received instruction on their most important IEP goal during extracurricular activities.This study reports on state-level data in Rhode Island on employment and non-work activities of adults with intellectual and developmental disabilities receiving services between 2011 and 2017. The goal was to examine the complex patterns of change over time in individual-level employment outcomes and the potential short-term impacts of a consent decree entered into by the state of Rhode Island to address integrated employment outcomes. Findings suggest that policy initiatives such as the consent decree can lead to reductions in reliance on facility-based work, but also highlight the importance of planning for the transition to competitive, integrated employment and not simply a shift toward non-work activities. Further, the data support the notion that the best predictor of integrated employment over time is previous experiences in integrated employment (not facility-based or other work or non-work activities), suggesting the role of ongoing supported employment and transition services that create and support the maintenance of integrated employment.Despite physically relocating into the community, many people with intellectual and developmental disabilities (IDD) fail to be meaningfully included in the community. The Home and Community Based Services (HCBS) Settings Rule was introduced to expand community integration, person-centered services, and choice. The aim of this exploratory study is to examine the potential impact of HCBS Settings Rule implementation, specifically by examining how the presence of HCBS Settings Rule outcomes impact three areas of health and safety. Zilurgisertib fumarate inhibitor We analyzed secondary Personal Outcome Measures data relating to the HCBS Settings Rule, and emergency room visits, abuse and neglect, and injuries data from 251 people with IDD. Findings indicate a clear need to improve HCBS Settings Rule related areas of people's lives.