Eskildsenroberts8440

Selection strongly favored earlier flowering when plants were grown in the complex microbial environment than compared to sterilized soil. We also uncovered a pattern of negative correlational selection on growth rate and flowering time, indicating that selection favored different combinations of growth and flowering traits in the simplified versus complex soil community. CONCLUSIONS Together, these results suggest the soil microbial community is a selective agent on flowering time and ultimately that soil microbial community influences important plant evolutionary processes. © 2020 The Authors. American Journal of Botany published by Wiley Periodicals, Inc. on behalf of Botanical Society of America.After their successful introduction during the 2007-2009 financial crisis, central bank stress tests were adopted as a fixture of international banking supervision. However, in recent years a new normal has emerged where banks are expected to pass the tests, raising questions about the tests' usefulness and legitimacy. Combining a dramaturgical interpretation of regulatory science with the idea of performativity in the sociology of finance, this article understands stress tests as a sociotechnical Goffmanian performance. With a focus on the Bank of England's program, the paper argues that the Bank's decision to make their tests "predictable" is an attempt to shore up central bank legitimacy by constraining regulatory discretion. This is accomplished through the use of calculative and procedural stage management techniques which allow the Bank to control the contingency of the testing process while demonstrating its objectivity. Nevertheless, the conclusion suggests that in the context of low levels of trust in central banks, routine declarations of "all clear" may undermine public confidence in the tests' credibility and necessity. The study draws on 20 interviews with high-level regulators, financial practitioners and other stakeholders in the Bank of England's stress tests. © 2020 London School of Economics and Political Science.AIM To describe the cognitive development of children with neurofibromatosis type 1 (NF1) and plexiform neurofibromas, and identify predictors of cognitive development. METHOD Participants included 88 children with NF1 and plexiform neurofibromas (50 males, 38 females, aged 6-18y, mean=12y, SD=3y 7mo) on a natural history study at the National Cancer Institute. Neuropsychological assessments (e.g. IQ, academic achievement, attention, and executive functioning) were administered three times over 6 years. RESULTS Relative to normative peers, the total sample of children with NF1 and plexiform neurofibromas demonstrated significantly lower scores in most cognitive domains and decreasing z-scores over time in math, writing, inhibitory control, and working memory. Children who had parents with (vs without) NF1 were more likely to experience decreased z-scores in performance IQ, reading, writing, attention, and working memory. Higher (vs lower) parental education was related to higher levels of IQ, math, reading, and cognitive flexibility and a slower decrease in math z-scores. Children's sex and the number of NF1 disease-related complications were not related to most cognitive outcomes. INTERPRETATION Children with NF1 and plexiform neurofibromas are at high risk for cognitive difficulties and declining z-scores in various domains of cognitive functioning over time. https://www.selleckchem.com/products/ly3009120.html The findings highlight the need for a better understanding of the within-group differences in these children and their need for individualized educational plans. WHAT THIS PAPER ADDS Math, writing, inhibitory control, and working memory scores decreased over time. The proportion of children with clinically significant cognitive deficits increased over time. Parental neurofibromatosis type 1 and low education were related to greater cognitive difficulties in children. Published 2020. This article is a U.S. Government work and is in the public domain in the USA.PREMISE Spiny pollen has evolved independently in multiple entomophilous lineages. Sexual selection may act on exine traits that facilitate male mating success by influencing the transfer of pollen from the anther to the body of the pollinator, while natural selection acts to increase pollen survival. We postulated that relative to sexual congeners, apomictic dandelions undergo relaxed selection on traits associated with male mating success. METHODS We explored sexual selection on exine traits by measuring the propensity for Taraxacum spp. pollen to attach to hairs of flower-visiting bumblebees (Bombus spp.) or flies (Diptera Syrphidae and Muscoidea) and assessed natural selection by testing whether pollen traits defend against consumption. RESULTS Pollen picked up by bumblebees exhibited a narrower subset of spine-spacing phenotypes, consistent with stabilizing selection. Flies picked up larger pollen from flowers than expected at random. Surveys of corbiculae (pollen basket) contents from foraging bumblebees and feces of flies showed that pollen grains consumed by both kinds of visitors are similar in spine characteristics and size to those produced by the donor. When bees visit inflorescences of apomictic T. officinale, they pick up pollen with spine-spacing phenotypes above the mean and shifted toward those of sexual T. ceratophorum. CONCLUSIONS We demonstrate that traits under sexual selection during pollen pickup vary among pollinators, while natural selection for pollen defense is nil in T. ceratophorum. In hybrid zones between apomictic and sexual dandelions, pollen traits place apomictic donors at a dispersal disadvantage, potentially reinforcing reproductive isolation. © 2020 Botanical Society of America.BACKGROUND AND PURPOSE GPCRs can signal through both G proteins and β-arrestin2. For the μ-opioid receptor, early experimental evidence from a single study suggested that G protein signalling mediates analgesia, whereas β-arrestin2 signalling mediates respiratory depression and constipation. Consequently, for more than a decade, much research effort has been focused on developing biased μ-opioid agonists that preferentially target G protein signalling over β-arrestin signalling, as it was believed that such drugs would be analgesics devoid of respiratory depressant activity. However, the prototypical compounds that have been developed based on this concept have so far failed in clinical and preclinical development. EXPERIMENTAL APPROACH The present study was set up to re-examine opioid-induced respiratory depression in β-arrestin2 knockout mice. To this end, a consortium was formed consisting of three different laboratories located in different countries to evaluate independently opioid-induced respiratory depression.