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from the track to avoid potential later vibration problem.In vulnerable subjects, the increase in air pollution worsens the signs of myocardial ischemia. Lockdown during COVID-19 pandemics substantially cleaned the air. The objective of this is to assess the effects of air cleaning due to lockdown on stress echocardiography (SE) results. We enrolled 19 patients with chronic coronary artery disease and/or heart failure referred to SE (semi-supine bicycle exercise, n = 8, or dipyridamole, n = 11). Before and soon after lockdown, we assessed regional wall motion abnormalities (abnormal value worsening of ≥ 2 segments), B-lines (a sign of pulmonary congestion, 4-site simplified scan, abnormal value ≥ 2), and coronary flow velocity reserve in left anterior descending artery (CFVR, abnormal value less then 2.0). Local air quality indicators (same day of SE) of fine particulate matter (PM2.5) and nitrogen dioxide (NO2) were obtained from publicly available data sets of the regional authority of environmental protection. After lockdown, NO2 concentration decreased from 19 ± 10 to 10 ± 4 μg/m3 (p = 0.006). After lockdown, abnormal responses remained unchanged for ischemia (21% vs 16%, p = ns) and decreased for B-lines (42% vs 5%, p = 0.008) and CFVR (84 vs 42%, p = 0.007). Changes in coronary flow velocity reserve (CFVR) were correlated to same-day variations in NO2 (r = -0.578, p = 0.010) and preceding 30-day changes in PM2.5 (r = -0.518, p = 0.023). After lockdown, air cleaning was associated with a beneficial effect on coronary small vessel dysfunction and alveolar-capillary barrier distress mirrored by improvement of CFVR and B-lines during SE in vulnerable patients. ClinicalTrials.gov Identifier NCT 030.49995.Over the last decades, the demographic changes have all altered the population structure and influenced the social, economic, and political characteristics of countries over the world. Therefore, the creation of novel ecosystems, new clusters and systems which involved technology and industry, business, education, science, and innovation are increased rapidly. However, in order to solve the future global challenges, the created various types of clusters, public and private sector systems should cooperate and work together as a unit. Therefore, one of the proposed solutions is unified regional ecosystems' building. The Interreg European Life Science Ecosystems (ELISE) project addresses the societal challenge which is common to the European regions to promote better health for all. This covers the need to improve health and well-being outcomes, to promote market growth, job creation, and EU competitiveness. Based on the project, three different regions of the European countries-Poland, Italy, and Germany-are selected in order to perform the analysis of drivers directly influencing the move from the existing clusters to unified regional ecosystem. The performed analysis showed that the government of a country and regional public authorities have the direct influence and play the central role in shaping unified regional ecosystems. The common economic, social, and political situation in a country is dependent on the government and it is influenced by the regional public authorities. Therefore, the collaboration and conversation among such institutions is the important factor defining how quickly different countries will create unified ecosystems and will solve the future problems.Life cycle assessment (LCA) is widely used to quantify the environmental performance of buildings. Recently, the potential temporal variations in the lifetime of buildings and their influences on assessment results have attracted considerable attention. Dynamic LCA (DLCA) is an emerging research topic. This study provides an overview of the current scenario of DLCA studies in the building field. A literature survey was conducted by searching through scientific literature databases; 48 articles met the inclusion criteria. Eleven dynamic variables as well as their addressing approaches were summarized and analyzed. A few typical dynamic assessment models were synthesized and compared to present the methodology progress. Finally, considering the existing limitations, a few research directions were recommended setting cutoff criteria for dynamic variables, developing a dynamic database, and considering the interactions between dynamic variables. https://www.selleckchem.com/products/YM155.html The analyses in this study indicate that research on the DLCA of buildings needs interdisciplinary cooperation. This review promotes in-depth understanding about DLCA research of buildings and offers valuable implications for environmental practice. The highlighted future research directions facilitate further explorations in this research area.Impact assessment of building materials is a focused topic in the field of radioecology. A radiological survey has conducted to monitor radioactivity of most common building materials in Semnan Province, Iran, and assess the radiation risk. Activity concentrations of 226Ra, 232Th, and 40K were measured in 29 samples including nine commonly used building materials that were collected from local suppliers and manufacturers, using a high purity germanium gamma-ray detector. The activity concentrations of 226Ra, 232Th, and 40K varied from 6.7±1 to 43.6±9, 5.9±1 to 60±11, and 28.5±3 to 1085±113 Bq kg-1 with averages of 26.8±5, 22.7±4, and 322.4±4 Bq kg-1, respectively. By applying multivariate statistical approach (Pearson correlation, cluster, and principal component analyses (PCA)), the radiological health hazard parameters were analyzed to obtain similarities and correlations between the various samples. The Pearson correlation showed that the 226Ra distribution in the samples is controlled by changing the 232Th concentration. The variance of 95.58% obtained from PCA resulted that the main radiological health hazard parameters exist due to the concentration of 226Ra and 232Th. The resulting dendrogram of cluster analysis also shows a well coincidence with the correlation analysis.In aquacultures, heavy metals could be accumulated in fish tissues from natural and human-related sources depending on different factors. This study aims to estimate the level of bioaccumulation of heavy metals in cultured Gilt-head sea bream Sparusaurata. In this regard, heavy metals concentrations were measured in both water and fish musculature that were collected from a private fish farm in Kafr ElSheikh, Egypt. Regarding the water samples, heavy metals were within the permissible limits with exception of Cd, Cu, and Zn. In fish musculature, all heavy metals were within the WHO/FAO permissible limits. The bioaccumulation factor (BAF) indicated that mostly all heavy metals accumulation in the Gilt-head sea bream musculature decreased with time which may be correlated with the increase in water pH, calcium, and other cations concentrations. The hazard index (HI) calculations indicate no adverse health effects of heavy metals on humans through daily fish consumption so far. However, health risks are not negligible making the regular monitoring of metal contaminants in the studied area a necessity.