Alexanderdinesen9582

Here, we described a novel, lean, user-friendly, open-access and open-source platform for calculating quantities related to light. The platform, called luox, enables researchers and research users in chronobiology, sleep research and adjacent field to turn spectral measurements into reportable quantities. The luox code base, released under the GPL-3.0 License, is modular and therefore extendable to other spectrum-derived quantities. luox has been endorsed by the CIE following black-box validation.Background Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P less then 5x10 -8) interactions with sex on lung function, and 21 showed suggestive interactions (P less then 1x10 -6). The strongest signal, from rs7697189 (chr4145436894) on forced expiratory volume in 1 second (FEV 1) (P=3.15x10 -15), was replicated (P=0.016) in SpiroMeta. The C allele increased FEV 1 more in males (untransformed FEV 1 β=0.028 [SE 0.0022] litres) than females (β=0.009 [SE 0.0014] litres), and this effect was not accounted for by differential effects on height, smoking or pubertal age. rs7697189 resides upstream of the hedgehog-interacting protein ( HHIP) gene and was previously associated with lung function and HHIP lung expression. We found HHIP expression was significantly different between the sexes (P=6.90x10 -6), but we could not detect sex differential effects of rs7697189 on expression. Conclusions We identified a novel genotype-by-sex interaction at a putative enhancer region upstream of the HHIP gene. Establishing the mechanism by which HHIP SNPs have different effects on lung function in males and females will be important for our understanding of lung health and diseases in both sexes.N/A.

We aimed to investigate the associations between the radiographic phenotypes and the presence of metabolic syndrome (MetS) in patients with knee osteoarthritis (OA).

We evaluated women age 40 and over who presented to our outpatient clinics with knee pain and fulfilled the clinical and radiographic criteria for the classification of idiopathic OA of the knee. Patients were categorized into two groups concerning dominant radiographic phenotype. We included consecutive 50 patients in each group. SW100 All patients were evaluated in terms of MetS according to the revised diagnostic criteria of the International National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the World Health Organization (WHO).

Overall MetS prevalence was found to be 79% according to the NCEP ATP III-MetS criteria and 65% according to the WHO-MetS criteria. Prevalence of MetS was higher in the joint space narrowing (JSN)-Dominant group compared to the osteophyte (O)-Dominant knee OA group, but the difference dggest that MetS is an independent risk factor for JSN-Dominant knee OA in patients with no past medical history of DM.

SARS-CoV-2 disease was announced as a pandemic by The World Health Organization on early 2020. It is still threatening the world population. Here, we aimed to produce hyperimmune sera that contain immunoglobulin G and F(ab')2 fragments sourced from horse antibodies as an urgent response to the pandemic.

SARS-CoV-2 was produced and inactivated with three different methods [formaldehyde (FA), formaldehyde and binary ethylene amine (FA+BEI), and heat treatment]. After in vitro inactivation control, immunogens were mixed with Freund?s adjuvant, thereafter horses (n 2 for FA, 4 for FA + BEI, 2 for Heat inactivation) and New Zealand rabbits (n 6 for FA, 6 for FA + BEI, 6 for Heat inactivation) were immunized four times. Neutralizing antibody levels of the sera were measured at the 4th, 6th and 8th weeks. When the antibodies were detected at the peak level, plasma was collected from horses and hyperimmune sera procured after the purification process.

Horses and rabbits produced highly neutralizing antibodies against the SARS-CoV-2 in FA and FA + BEI inactivation groups, foreign proteins were removed effectively after purification.

This study presents a profitable practice to develop horse specific antisera against SARS-CoV-2 for emergency and low-cost response. In further studies, new purification methods can be used to increase the efficiency of the final product.

This study presents a profitable practice to develop horse specific antisera against SARS-CoV-2 for emergency and low-cost response. In further studies, new purification methods can be used to increase the efficiency of the final product.

Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than 13,000 people in South Korea by July 2020. To prevent spread of COVID-19, tele-prescription was permitted temporarily. This study investigated the impact of tele-prescription on glycemic control in patients with type 2 diabetes.

Glycated hemoglobin (HbA1c) concentrations were retrospectively analyzed in patients with type 2 diabetes who were treated with tele-prescription because of COVID-19 and those who were treated by face-to-face care (non-tele-prescription group) enrolled at the same period of time. Mean HbA1c concentrations and mean change in HbA1c concentration (ΔHbA1c) were compared in these two groups.

The mean HbA1c levels of patients were significantly higher after than before the tele-prescription period (7.46% ± 1.24% vs. 7.27% ± 1.13%, p < 0.05). Mean ΔHbA1c was significantly higher in the tele-prescription than in the non-tele-prescription group (0.19% ± 0.68% vs. 0.04% ± 0.95%, p < 0.05). HbA1c was significantly greater in patients taking fewer oral hypoglycemic agents, no insulin, fewer comorbidities (e.g., coronary artery disease, cerebrovascular accident, and diabetic neuropathy), and higher baseline HbA1c.

Tele-prescription may worsen glycemic control in patients with type 2 diabetes during public health crises.

Tele-prescription may worsen glycemic control in patients with type 2 diabetes during public health crises.