Baggerwichmann0390
placement of locking screws provides superior stability for fixation of comminuted patellar fractures when compared to both antero-lateral mesh plating and TBW. The latter is associated with considerably inferior performance.
Anterior mesh plating with biplanar placement of locking screws provides superior stability for fixation of comminuted patellar fractures when compared to both antero-lateral mesh plating and TBW. The latter is associated with considerably inferior performance.
Hepatocyte growth factor (HGF) is a multifunctional growth factor that promotes various biological processes. However, the effect of HGF on bone metabolism in rheumatoid arthritis (RA) remains unknown. Here, we investigated the role of HGF in regulating osteoclastogenesis and bone resorption in RA.
The expression of HGF in RA patients and collagen-induced arthritis (CIA) mice was examined. The role of HGF on osteoclastogenesis was analysed by osteoclastogenesis and bone resorption assays. The effect of HGF inhibition was evaluated in a CIA mice model. The mechanism of HGF in regulating osteoclastogenesis and bone resorption was explored by a series of in vitro studies.
HGF was overexpressed in CIA and RA. HGF stimulated osteoclastogenesis in vitro. SU11274, a selective small molecule blocker of c-Met, impeded the effect of HGF on osteoclastogenesis and bone resorption. HGF regulated osteoclastogenesis by JNK and AKT-GSK-3β-NFATc1 signallings. SU11274 protected CIA mice from pathological bone loss.
These data strongly suggest that the highly expressed HGF in the joint tissues contributes to bone loss in RA. Inhibition of HGF/c-Met could effectively alleviate pathological bone loss and inflammatory symptoms in CIA mice. HGF/c-Met may be used as a new target for the treatment of bone loss in RA.
These data strongly suggest that the highly expressed HGF in the joint tissues contributes to bone loss in RA. Inhibition of HGF/c-Met could effectively alleviate pathological bone loss and inflammatory symptoms in CIA mice. HGF/c-Met may be used as a new target for the treatment of bone loss in RA.
The treatment of recalcitrant not-diabetic leg ulcers remains challenging. Distraction osteogenesis is accompanying by angiogenesis and neovascularization in the surrounding tissues. We previously applied tibial cortex transverse transport (TTT) to patients with recalcitrant diabetic foot ulcers and found neovascularization and increased perfusion in the foot and consequently enhanced healing and limb salvage and reduced recurrence. selleckchem However, the effects of TTT on recalcitrant non-diabetic leg ulcer remains largely unknown.
Consecutive patients (n=85) with recalcitrant non-diabetic leg ulcers (University of Texas Grade 2-B to 3-D, ie, wound penetrating to the tendon, capsule, bone, or joint with infection and/or ischemia) were recruited and divided into TTT (n=42) and control (n=43) groups based on the treatment they received. There were 36 (85.7%) arterial ulcers, 4 (9.5%) venous ulcers and 2 (4.8%) mixed ulcers in the TTT group and 32 (74.4%) arterial ulcers, 7 (16.7%) venous ulcers and 4 (9.3%) mihe findings suggest TTT as an effective procedure to treat recalcitrant chronic leg ulcers.
TTT can be used as an effective treatment for recalcitrant non-diabetic leg ulcers in patients. The mechanism may be associated with the neovascularization in the ulcerated foot induced by TTT and consequently increased perfusion. Together with previous findings from recalcitrant diabetic leg ulcers, the findings suggest TTT as an effective procedure to treat recalcitrant chronic leg ulcers.Few studies have provided information on parasitological indexes or other ecological characteristics of lice populations that parasitize small mammals in the Neotropical region. We used lice parasitizing a rodent species, Trinomys iheringi, as a study model to investigate the effect of parasite occurrence and intensity on the body condition of rodents and the effect of climatic conditions, sex and age class of T. iheringi. We also provide information on prevalence, mean intensity, aggregation, sexual ratio of adult lice, and proportion between life stages and lice parasitizing T. iheringi. The study was conducted in Ilha Grande, an island in southeastern Brazil. We used a logistic regression to run a model of lice occurrence using climatic variables (rainfall, temperature, humidity), and then adding sex and age classes. A total of 39 T. iheringi individuals were captured with 17 parasitized (43.58%). These animals hosted Gyropus (martini) martini (n = 94), Gliricola sp. (n = 8), and Pterophthirus wernecki (n = 2). The model with humidity and sex variables showed that the occurrence of lice was negatively associated with humidity. There are more males than females infested with lice, while most of the young individuals are not infested. The higher lice occurrence in the low humidity coincides with the birth period of T. iheringi. The contact among individuals are higher during the reproductive period of the host species, but males are more suscetible to the lice parasitism due to higher testosterone levels that reduce the immunocompetence. The distribution pattern of lice was aggregated, but there was no correlation between body condition index and lice infestation intensity. We highlight that the major occurrence of lice occurs in the driest period of the year, that males are more prone to parasitism by lice than females, and adults more prone than young.
The use of scaling, root planing, antimicrobials, or antibiotics in the treatment of Chronic Periodontitis have proven beneficial in the past. The reduction in inflammatory markers and significant resolve in the clinical signs and symptoms and microbial loads evinced by a number of studies are a clear corroboration of the fact, but certain restraints utilizing these methods call for more effective ways of treating the disease. Later, lasers or photodynamic dyes used with the lasers like methylene blue or toluidine blue O have also not proven much efficacy and need further research. Hence the present pilot study is a step forward in this direction as it helps analyse the microbiological and clinical effects of indocyanine green antimicrobial photodynamic therapy an as adjunct to the non-surgical periodontal therapy in treating chronic periodontitis patients.
30 patients diagnosed with generalized chronic periodontitis were treated with scaling and root planing alone - control sites; and indocyanine green antimicrobial photodynamic therapy in addition to scaling and root planing - experimental sites.
