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Prevention and treatment of periodontitis reduces the increase of several systemic diseases that accordingly reduces the treatment resources and expenses.Periodontal diseases are widespread in children and adolescents. By the information of World Health Organization, 80% of children have different degrees of inflammatory periodontal diseases, that often develop from the ages of 10-11 years. Pathology of periodontal tissues is developed when there is a disproportional growth and development of tissue structure, as within the system, also in the systems and structures that provide entire organism, which itself supplements the development of periodontal diseases in juveniles. Harmonious development of children and adolescents is, on a certain level, dependent on the proper functioning of endocrine system, the functional state of which is judged by the hormones it produces, specifically cortisol. The goal of our study was to determine the level of salivary cortisol in children during puberty, also reveal the connection between the hormonal disbalance and the periodontal tissue pathologies. Furosemide research buy To achieve this, we have studied 50 students of age 11-16 years. To assess periodontal tissue state we used clinical-instrumental and roentgenologic methods, while the salivary cortisol levels were determined by the enzyme-linked immunosorbent assay (ELISA) method. Tests showed the connection between the hormonal disbalance and ongoing pathologic processes in periodontal tissue, more specifically, in children with high salivary cortisol levels, in the study group (average in males 2.29, in females 2.22) majority (67%) had severe forms of inflammatory periodontal diseases, which gives us a ground to conclude that in juveniles with the inflammatory periodontal diseases, functional reserve of adrenal gland is diminished.Aim of the study- improving the methods of prevention and hygiene of the oral mucosa of dental patients receiving high-dose toxic chemotherapy. 55 patients aged from 30 to 65 years of oncological profile with a combined dental pathology were taken for clinical observation. Patients were divided into 2 groups according to the applied methods of oral hygiene in group 1, a standard hygienic technique was used; group 2 additionally used the hygiene and prophylactic agent "CITO-STOP", adapted for patients undergoing high-dose chemotherapy. Measurement and comparison of the amount of methotrexate in the oral fluid in both groups was carried out according to a single scheme. The measurement was carried out by high performance liquid chromatography immediately before the introduction of methotrexate, then after the start of infusion at the following time intervals 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 16 hours, 24 hours, 48 hours, respectively. The study of Candidaalbicans on sensitivity to the author's hygiene been proven to decrease. "CYTO-STOP" has a pronounced fungicidal activity Patients of the second group who used the "CITO-STOP" foam for additional oral hygiene and the prevention of post-cytostatic stomatitis noted an improvement in the quality of life by reducing the pain symptom, eliminating bleeding of the mucous membrane and halitosis (halitosis).The purpose of this review was to systematize the data on the effect of endometriosis on the fertility index, the course of pregnancy, and the modern diagnosis of changes the endometriotic implants during pregnancy. There are many factors that can potentially affect fertility in patients with endometriosis anatomical changes in the pelvic floor, impaired transport function of the fallopian tubes due to the formation of adhesions, impaired steroid and folliculogenesis, anovulation and peritoneal changes that contribute to the formation of a harmful prooxidant microenvironment, which can affect the quality and quantity of oocytes and cause a violation of the susceptibility of the endometrium. If the patient with endometriosis still managed to get pregnant, then the problem of maintaining this pregnancy arises even more. The data indicate that pregnancy has a positive effect on the symptoms of endometriosis, and also has a beneficial effect on the growth rate and relapse rate of endometriosis, and may also cause a regression of the formed endometriotic implants. However, data on the effect of pregnancy on endometriosis are contradictory, and pregnancy in women with endometriosis does not always lead to the disappearance of symptoms and a decrease in the size of endometrioid lesions. Moreover, there is growing evidence that endometriosis can affect pregnancy outcomes. Currently, it is impossible to predict changes in the endometriotic implants due to insufficient knowledge about the pathogenesis of this disease. A deeper understanding of the pathogenesis should help prevent hasty obstetric decisions that can lead to iatrogenic diseases in newborns, and patients should be informed about possible complications during pregnancy when planning a birth.The aim of the study was to determine the correlation between implanted IOL material type and posterior capsule opacification. At 12 month, there was no statistically and visually significant changes in all controlled groups. At 18 month, 3 eyes (5.2%) from Group 2 and 1 eye (5.8%) from hydrophobic arm of Group 3 had visually significant PCO and underwent NdYAG laser posterior capsulotomy. 8 eyes (10.8%) in group 1 and 3 eyes (17.6%) in hydrophilic arm of Group 3 required NdYAG laser posterior capsulotomy. At 3, 6, and 12 month compared to baseline (1 month postoperatively), there was no statistically and clinically significant difference in visual acuity and subjective refraction between the groups. At 12 month, 3 patients (4%) from group 1 and 1 patient (6%) from hydrophilic arm of group 3 complained of glare sensitivity, especially in mesopic conditions. At that point, interestingly, no patient from Group 2 and hydrophobic arm of Group 3 complained about glare sensitivity. In terms of UCDVA, 68 eyes of gro. There was no changes in contrast sensitivity in eyes of Group 2 at 12 month period. The study is still ongoing. The patients will be evaluated at 24 month and 36 month postoperatively.

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