Herrerakok2711

As letters form the vocabulary of a language, biochemical 'symbols' (the building blocks of oligo- and polymers) make writing molecular messages possible. Compared to nucleotides and amino acids, sugars have chemical properties that facilitate to reach an unsurpassed level of oligomer diversity. These glycans are a part of the ubiquitous cellular glycoconjugates. Cyto- and histochemically, the glycans' structural complexity is mapped by glycophenotyping of cells and tissues using receptors ('readers', thus called lectins), hereby revealing its dynamic spatiotemporal regulation these data support the concept of a sugar code. When proceeding from work with plant (haem)agglutinins as such tools to the discovery of endogenous (tissue) lectins, it became clear that a broad panel of biological meanings can indeed be derived from the sugar-based vocabulary (the natural glycome incl. selleck chemicals post-synthetic modifications) by glycan-lectin recognition in situ. As consequence, the immunocyto- and histochemical analysis of lectin expression is building a solid basis for the steps toward tracking down functional correlations, for example in processes leading to cell adhesion, apoptosis, autophagy or growth regulation as well as targeted delivery of glycoproteins. Introduction of labeled tissue lectins to glycan profiling assists this endeavor by detecting counterreceptor(s) in situ. Combining these tools and their applications strategically will help to take the trip toward the following long-range aim to compile a dictionary for the glycan vocabulary that translates each message (oligosaccharide) into its bioresponse(s), that is to crack the sugar code.Social scientists have increasingly recognized the lack of diversity in survey research on American religion, resulting in a dearth of data on religion and spirituality (R/S) in understudied racial and ethnic groups. At the same time, epidemiological studies have increasingly diversified their racial and ethnic representation, but have collected few R/S measures to date. With a particular focus on American Indian and South Asian women (in addition to Blacks, Hispanic/Latinas, and white women), this study introduces a new effort among religion and epidemiology researchers, the Study on Stress, Spirituality, and Health (SSSH). This multi-cohort study provides some of the first estimates of R/S beliefs and practices among American Indians and U.S. South Asians, and offers new insight into salient beliefs and practices of diverse racial/ethnic and religious communities.Transitional justice, like other peacebuilding endeavours, strives to create change in the world and to produce knowledge that is useful. However, the politics of how this knowledge is produced, shared and rendered legitimate depends upon the relationships between different epistemic communities, the way in which transitional justice has developed as a field and the myriad contexts in which it is embedded at local, national and international levels. In particular, forms of 'expert' knowledge tend to be legal, foreign and based on models to be replicated elsewhere. Work on epistemic communities of peacebuilding can be usefully brought to bear on transitional justice, speaking to current debates in the literature on positionality, justice from below, marginalisation and knowledge imperialism. This article offers two contributions to the field of transitional justice (1) an analysis of the way the field has developed as an epistemic community(ies) and the relevance of this for a politics of knowledge; and (2) an argument for the politics of knowledge to be more widely discussed and understood as a factor in shaping transitional justice policy and practice, and as a call to a more ethical relationship with the supposed beneficiaries of transitional justice interventions.While recent studies find a strong association between the share of women in elected office and lower levels of corruption, we know less about if women in executive office cause reductions in corruption levels, and if such effects last over time. This study suggests that women mayors reduce corruption levels, but that the beneficial effect may be weakened over time. Using both regression discontinuity and first difference designs with newly collected data on French municipal elections combined with corruption risk data on close to all municipal contracts awarded between 2005 and 2016, we show that women mayors reduce corruption risks. However, newly elected women mayors drive the results, while gender differences are negligible in municipalities where women mayors are re elected. Our results can be interpreted as providing support for marginalization theories, but also suggest that the women that adapt to corrupt networks survive in office.We present a drawing discovery lab that crosscuts multiple disciplines in biology and links concepts in genetics and evolutionary thinking to enhance understanding of the genotype-to-phenotype transformation. These combined concepts are also linked to ecological frameworks in nature through the model of biological plasticity. Students and teachers explore drawing skills to flesh out the future of a predator while engaging with the computational software MEGA, which introduces students and teachers to nucleotide changes, mutations, variation, phylogenetics, and molecular evolution.

Dermatologic care was halted because of the coronavirus disease 2019 pandemic, prompting us to study the usefulness of direct-to-patient teledermatology via a mobile application. We aimed to evaluate the service as a tool for avoiding face-to-face consultations, describe the main conditions diagnosed, and assess levels of patient and physician satisfaction.

Prospective descriptive study of new patients who met the inclusion criteria. Descriptive statistics for all variables were analyzed with SPSS.

Of the 1,497 patients who agreed to participate in the study, 25% (n = 374) sent an image to a consultant dermatologist through the mobile application. Sixty-four patients (17%) were discharged directly and referred to primary care for follow-up. A face-to-face consultation was avoided for at least 3 months in 85% of patients (n = 318); 87.1% (n = 325) received a diagnosis and the dermatologist's level of confidence in this diagnosis was 7 or higher in 77.5% of cases (n = 290). The quality of the images sent was considered sufficient in 52.