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CONCLUSION The old concept that Schistosomiasis is associated with SCC should be revaluated as most cases are associated with TCC. Relying on the histopathology for confirmation of Schistosomiasis in our research studies appears to be non-accurate and leads to irrelevant results. Copyright © 2019 Hebat Allah Ahmed Amin, Mohamed Hamed Kobaisi, Rasha Mohamed Samir.BACKGROUND Functional constipation (FC) is a common health problem in paediatrics that causes significant physical and emotional distress to patients and their families. AIM In the current work, we assessed the presence of behavioural problems in children with functional constipation and their pattern and relation to various demographic and disease-associated factors. METHODS A cross-sectional case-control study was conducted, including 55 consecutive children aged 4-16 years diagnosed with functional constipation and 55 healthy age and sex-matched controls. Psychological assessment was done using the Pediatric Symptom Checklist - 17 (PSC-17). RESULTS Twenty-six (47.3%) patients with FC had positive total PSC-17 scores while none of the controls had positive scores (p-value less then 0.001). Positive internalising and externalising behaviours scores and attention problems were found in 36 (65.5%), 15 (27.3%) and 12 (21.8%) of the patients respectively in contrary to controls where only 6 (10.9%) had positive scores in internalising behaviour, and non-showed externalising behaviour and 4 (7.3%) were inattentive. Older age, longer duration of illness, residency in rural areas and presence of encopresis were found to have a significant association with the presence of such problems. CONCLUSION Children with FC have more behavioural disorders compared to healthy controls. Daurisoline cell line Integration of psychosocial aspects and their management is recommended during dealing with patients with FC. Copyright © 2019 Marwa M. El-Sonbaty, Ahmed Fathy, Amal Aljohani, Abeer Fathy.BACKGROUND Knee osteoarthritis (OA) is the most common degenerative disorder occurring in older people. Radiography and sonography are convenient techniques to detect diverse pathological features of knee OA. AIM The aim of the present study was to evaluate the diagnostic efficacy of radiography and sonography in the detection of diverse features of knee OA. METHODS In a prospective cross-sectional diagnostic accuracy study, 50 consecutive patients with suspected knee OA (40 women and 10 men, mean age 41.2 ± 6.1 years), referred to the rheumatology clinic of the Shohada Hospital of Khorramabad. All obtained magnetic resonance imaging (MRI), radiographic and sonography images were evaluated by two radiologists and rheumatologist with sufficient expertise in degenerative knee disorders. MRI has been considered as a gold standard test in evaluating other tests. The sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV) and accuracy with 95% confidence intervals of radiography and sonography in the diagnosis of knee OA were calculated. RESULTS Prevalence of the marginal osteophyte, geode and decreased joint thickness were significantly higher in patients with age > 40 years compared to ≤ 40 years (P less then 0.05). The incidence of diverse features of knee OA was not significantly different in terms of the patient's gender, except for decreased joint space. The specificity of radiography was higher than its sensitivity. CONCLUSION Our study showed that both radiography and sonography are useful imaging modalities, especially to diagnosis the positive cases of knee OA. The specificity of radiography is higher than to its sensitivity for all pathological features of knee OA. The sensitivity of sonography to detect some features of knee OA such as decreased joint thickness is considerably higher than radiography. Copyright © 2019 Hadi Majidi, Fatemeh Niksolat, Khatereh Anbari.BACKGROUND Weaning from invasive mechanical ventilation (MV) is considered as a daily challenging practice in the management of critically ill patients. The use of lung ultrasound and change in haemoglobin and hematocrit during weaning may help to predict weaning outcomes. AIM We aim to study the impact of weaning induced pulmonary edema on outcomes of weaning from mechanical ventilation. PATIENTS AND METHODS Sixty patients who fulfilled readiness criteria for weaning from MV. Spontaneous breathing trial (SBT) on T-piece for 120 minutes was performed under close hemodynamic monitoring. Lung ultrasound was performed using eight lung zones protocol to detect both the presence and the trend of change in B lines before and after SBT. For all the studied patients, haemoglobin and hematocrit values were checked just before and at the end of SBT. RESULTS Patient who failed to pass SBT showed significant increase in lung segments showing B pattern, haemoglobin and hematocrit levels (p-value less then 0.001 for all) also those patients had significantly higher duration of ICU stay (p-value less then 0.001) Despite mortality rate was higher among patients who failed SBT yet it was statistically insignificant (p-value 0.104). CONCLUSION lung ultrasound and both haemoglobin and hematocrit levels correlate with weaning outcomes. Copyright © 2019 Mahmoud Khaled Nour, Hany Tawfik Fathelbab, Ahmad Hosam Mwafy, Mohamad Ashraf Shawky, Santiago Jesús Camacho Freire, Javier León Jiménez, Jessica Roa Garrido, Antonio Enrique Gómez Menchero, Rosa Cardenal Piris, José Francisco Díaz Fernández, Samir ELhadidy Tawfik.BACKGROUND One of the common complications of diabetic patients is sclerodactyly which is considered as a part of limited joint mobility. AIM To assess sclerodactyly in adolescent type 1 diabetics and to detect its relation to other diabetic complications. METHODS Sixty-three diabetics and 60 controls were studied. Clinical, laboratory assessment, ultrasonography of the skin, carotid artery intima-media thickness (cIMT) & renal colour duplex were done for all participants. RESULTS Sclerodactyly was positive in 12 (19%) of diabetics. Patients with sclerodactyly had a significantly thickened skin compared to patients without sclerodactyly and controls, P = 0.0001. Male diabetics had significantly thickened skin (p = 0.0001). Diabetic patients with sclerodactyly had significant higher systolic blood pressure (p = 0.03), cholesterol (p = 0.05) and triglyceride (p = 0.004) and lower HDL-c (p = 0.04). Skin thickness had a significant positive correlation with age of diabetic patients (p = 0.02), waist/height ratio (p = 0.