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The antiviral activity of some trace elements is attributed to their inhibitory effect on viral entry, replication and other downstream processes. Trace elements having antioxidants activity not only regulate host immune responses, but also modify the viral genome. Adequate dietary intake of trace elements is essential for activation, development, differentiation and numerous functions.Within half a year, COVID-19 spreads to most countries in the world, as well as posed a great threat to the public health of human beings. Enitociclib cell line The implementation of non-pharmaceutical intervention (NPI), including travel ban, proved to be an effective way for controlling the epidemic spreading, e.g., the ban of inter-city transportation stops transporting virus through passengers between cities. However, travel ban could significantly impact many industries, e.g. tourism and logistics, thus jeopardizing the regional economy. This paper focus on assisting the national or regional government to make dynamic decisions on restricting and recovering intercity multi-modal travel services. Our model can characterize impacts of inter-city traffic on the spread of the COVID-19, as well as on the regional economy. By applying a reinforcement learning approach, we develop an online optimization model to identify the modal-specific travel banning strategy that can balance the epidemic control as well as the negative impacts on regional economy. The numerical study based on a network of multiple cities in China shows that the proposed approach can generate better strategies compared with some existing methods.As of November 14, 2020, the number of people infected with the COVID-19 disease has reached more than 54 million people worldwide and more than 1323196 people have died, according to the World Health Organization. This requires many countries to impose a health emergency or quarantine, which has had positive results in reducing the spread of the COVID-19 pandemic, and it has also had negative economic, social and health effects. So, we suggest a mathematical model for the dynamics of how COVID-19 disease is spread, as well as a mathematical modeling for the dynamics of diabetes, then highlight the negative effect of quarantine has on the health of diabetics. Pontryagin's maximum principle is used to characterize the optimal controls, and the optimality system is solved by an iterative method. Finally, some numerical simulations are performed to verify the theoretical analysis using MATLAB.The outbreak of coronavirus is spreading at an unprecedented rate to the human populations and taking several thousands of life all over the globe. In this paper, an extension of the well-known susceptible-exposed-infected-recovered (SEIR) family of compartmental model has been introduced with seasonality transmission of SARS-CoV-2. The stability analysis of the coronavirus depends on changing of its basic reproductive ratio. The progress rate of the virus in critical infected cases and the recovery rate have major roles to control this epidemic. Selecting the appropriate critical parameter from the Turing domain, the stability properties of existing patterns is obtained. The outcomes of theoretical studies, which are illustrated via Hopf bifurcation and Turing instabilities, yield the result of numerical simulations around the critical parameter to forecast on controlling this fatal disease. Globally existing solutions of the model has been studied by introducing Tikhonov regularization. The impact of social distancing, lockdown of the country, self-isolation, home quarantine and the wariness of global public health system have significant influence on the parameters of the model system that can alter the effect of recovery rates, mortality rates and active contaminated cases with the progression of time in the real world.One of the main challenges in times of sanitary emergency is to quickly develop computer aided diagnosis systems with a limited number of available samples due to the novelty, complexity of the case and the urgency of its implementation. This is the case during the current pandemic of COVID-19. This pathogen primarily infects the respiratory system of the afflicted, resulting in pneumonia and in a severe case of acute respiratory distress syndrome. This results in the formation of different pathological structures in the lungs that can be detected by the use of chest X-rays. Due to the overload of the health services, portable X-ray devices are recommended during the pandemic, preventing the spread of the disease. However, these devices entail different complications (such as capture quality) that, together with the subjectivity of the clinician, make the diagnostic process more difficult and suggest the necessity for computer-aided diagnosis methodologies despite the scarcity of samples available to do so. To solve this problem, we propose a methodology that allows to adapt the knowledge from a well-known domain with a high number of samples to a new domain with a significantly reduced number and greater complexity. We took advantage of a pre-trained segmentation model from brain magnetic resonance imaging of a unrelated pathology and performed two stages of knowledge transfer to obtain a robust system able to segment lung regions from portable X-ray devices despite the scarcity of samples and lesser quality. This way, our methodology obtained a satisfactory accuracy of 0.9761 ± 0.0100 for patients with COVID-19, 0.9801 ± 0.0104 for normal patients and 0.9769 ± 0.0111 for patients with pulmonary diseases with similar characteristics as COVID-19 (such as pneumonia) but not genuine COVID-19.Nursing courses for family caregivers are a public health-relevant offer. Simulation training is an innovative way of building up practical skills for various care situations at home. Simulation training is a learning method that replicates real-life situations to improve the safety, effectiveness and efficiency of healthcare services. Essentially, simulation training provides learners with a controlled and safe learning environment without exposing patients to risk. Simulation training for family caregivers is new. The Albert Schweitzer Training Center at Geriatric Health Centers began offering this hands-on learning method in its family caregiver courses in 2018. In addition to an extensive literature review on this topic, a training participant and a simulation expert report about their experiences with this teaching and learning method.