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Cellular heterogeneity is an important biological phenomenon observed across space and time in human tissues. Imaging-based spatial proteomic technologies can provide fruitful new readouts of phenotypic states for individual cells at subcellular resolution, which may help unravel the roles of non-genetic cellular heterogeneity in tumorigenesis and drug resistance.

To describe the meaning that pregnant women with preeclampsia attach to nursing care in an obstetric intensive care unit of a hospital in Neiva (Colombia).

Qualitative-phenomenological study, guided by the theoretical guidelines of Diekelmann, Allen and Tanner. The data was collected during the second semester of 2017 and the first semester of 2018, through in-depth interviews with eleven participants, which were subsequently analysed until reaching theoretical saturation.

273 significant fragments, eight common meanings and four emerging themes establishing links that satisfy, an invisible woman, approaching a transpersonal relationship of care, and the pursuit of understanding emerged from this study.

Admission to the obstetric intensive care unit due to severe pre-eclampsia represents a change of role for women who, in addition to undergoing physical changes, also manifest a variety of emotions related to the circumstances of care and the actions of nurses.

Admission to the obstetric intensive care unit due to severe pre-eclampsia represents a change of role for women who, in addition to undergoing physical changes, also manifest a variety of emotions related to the circumstances of care and the actions of nurses.

This study aimed to evaluate the efficacy of Hegde's modification of Fothergill surgery, an innovative procedure for cervical elongation (CE), and to report perioperative challenges and follow-up.

This is a retrospective review of data from 12 patients who underwent successful repair of CE by Hegde's modification of Fothergill surgery from June 2012 to May 2019. Primary outcomes were cervical viability and stenosis. Secondary outcomes were perioperative complications, Pelvic Organ Prolapse Quantification system (POP-Q) measurement and staging, recurrence, conception rates, and World Health Organization Quality of Life (QOL) BREF (WHOQOL-BREF) scores.

All women had a viable, patent cervix at 1-month follow-up. Perioperative complications included total intraoperative blood loss (>50 mL) and febrile morbidity (both 16.7%) and urinary tract infections (8.3%). The mean reduction of point C was 5.78 cm (2.87 ± 0.13 cm to -2.91 ± 1.55 cm). Recurrence was noted in 1 patient (8.3%) who had POP-Q stage 2 prolapse at 6 and 12 months of follow-up. The conception rate was 8.3% at 12 months. All women conceived spontaneously. Mean preoperative WHOQOL-BREF scores improved in all 4 domains, with major improvement seen in the physical domain, from 24.66 ± 8.18 to 70.91 ± 11.01, 19.0 ± 6.48 to 54.92 ± 8.21, 9.33 ± 7.46 to 59.33 ± 14.33, and 19.0 ± 4.89 to 47.07 ± 7.14, for the physical, psychological, social, and environmental domains, respectively.

Hegde's modification of Fothergill surgery can be considered as a surgical option for the repair of isolated CE with a healthy cervix in women who desire uterine preservation with the major advantage of preventing cervical stenosis.

Hegde's modification of Fothergill surgery can be considered as a surgical option for the repair of isolated CE with a healthy cervix in women who desire uterine preservation with the major advantage of preventing cervical stenosis.

Several studies have reported that mitral regurgitation (MR) can improve following transcatheter aortic valve replacement (TAVR) alone using earlier generation valves. The purpose of this study was to determine the predictors and short-term outcome impact of MR in patients undergoing TAVR using all generation valves across all risk groups.

In this retrospective, study from 2012 to 2020, we reviewed data on 1822 low, intermediate and high-risk patients who underwent TAVR. Included were 1266 patients with baseline MR who underwent transfemoral TAVR. Our primary outcome was persistence or worsening of baseline MR post-TAVR. Additional endpoints included an inpatient composite (intensive care unit length of stay >24h, post-TAVR length of stay >2days and inpatient death), 30-day composite (30-day death or readmission) and 1-year composite (1-year death or readmission).

Of the 1266 patients included, 665 had significant baseline MR (≥moderate), which improved in 79.4% of patients (n=528). Female patients, those with lower body mass indices and those with higher right ventricular systolic pressures were more likely to have persistence or worsening of baseline MR. Patients whose baseline MR persisted or worsened, had higher rates (80.3 vs. 77.3%, p=0.0019) of our inpatient composite, higher rates (15.3% vs. 10.0%, p=0.0389) of our 30-day composite and higher rates (36.7% vs. 26.8%, p=0.0107) of our 1-year composite when compared to patients whose baseline MR improved post-TAVR.

Our study identifies clinical characteristics, which help identify patients who may require closer post-procedural follow-up and warrant possible staged mitral valve intervention post-TAVR across all risk groups.

Our study identifies clinical characteristics, which help identify patients who may require closer post-procedural follow-up and warrant possible staged mitral valve intervention post-TAVR across all risk groups.

The personality traits of conscientiousness and neuroticism have been consistently linked to mean-level, self-reported sleep duration and continuity. The present study expands this literature by using actigraphy sleep assessment to examine how personality is related to both mean-level and the intraindividual variability in sleep duration, continuity, and timing.

One-week ecological sleep assessment.

The research was conducted at a mid-size Midwestern university. Actigraphy data were collected at participants' homes.

The study had a sample size of 358 college-aged participants.

Sleep duration, continuity, and timing were assessed for 7 consecutive nights using actigraphy. Participants also completed a self-report assessment of personality.

Conscientiousness and extraversion emerged as the key personality predictors of sleep outcomes. selleck chemical Higher conscientiousness was associated with longer average sleep duration and earlier timing, as well as higher consistency in total sleep time. Higher extraversion was associated with later bedtimes, less total sleep time, and more variability in their sleep timing.