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WHAT THIS STUDY ADDS Few cases of ICI and VZV reactivation have been reported in the literature. Full and timely resolution of VZV-GD allowed the continuation of ICI treatment. © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.As the most important transcription factor in the brassinosteroid (BR) signal transduction pathway, the BES1 transcription factors not only affect the growth and development of plants but also regulate the stress resistance of crops. The physicochemical properties, gene structure, cis-acting elements and gene chip expression of apple BES1 transcription factors were analyzed by bioinformatics, and the expression of this gene family was analyzed by qRT-PCR. The results showed that the apple BES1 transcription factors had 22 members, distributed in 8 chromosomes of the apple genome, which were divided into seven subtribes (I-VII), and the same subtribe contained the same motifs basiclly. Gene structure analysis showed that the number and position of exons were different, and there was no upstream and downstream structure. The analysis of cis-acting elements indicated that BES1 transcription factors contained response elements of hormones and abiotic stress, as well as organ-specific elements. Gene chip expression profile analysis revealed that the expression patterns of the BES1 transcription factors were different in different apple hybrids and different organs. In addition, the expression levels of apple BES1 genes were higher in flowers, young fruits, mature fruits, and leaves. qRT-PCR analysis demonstrated that the expressions of MdBES1 genes were the highest at 12 h after BR induction. At the same time, there were different expressions in response to PEG, NaCl and MeJA. This paper provides some theoretical basis for the analysis of the biological function and stress resistance mechanism of BES1 transcription factors in apple. This article is protected by copyright. All rights reserved.Breastfeeding provides optimal nutrition for the healthy growth of infants and is associated with reduced risks of infectious diseases, child and adult obesity, type 2 diabetes, and other chronic diseases. Migration has been shown to influence breastfeeding especially among migrants from low-and-middle-income countries. This mixed-methods systematic review aimed to identify, synthesise, and appraise the international literature on the breastfeeding knowledge and experiences of African immigrant mothers residing in high-income countries. MEDLINE, CINAHL, Embase, PsychINFO, Scopus, and Web of Knowledge databases were searched from their inception to February 2019. Grey literature, reference, and citation searches were carried out and relevant journals hand-searched. Data extraction and quality assessment were independently carried out by two reviewers. An integrated mixed-methods approach adopting elements of framework synthesis was used to synthesise findings. The initial searches recovered 8,841 papers, and 35 studies were included in the review. Five concepts emerged from the data (a) breastfeeding practices, showing that 90% of African mothers initiated breastfeeding; (b) knowledge, beliefs, and attitudes, which were mostly positive but included a desire for bigger babies; (c) influence of socio-demographic, economic, and cultural factors, leading to early supplementation; (d) support system influencing breastfeeding rates and duration; and (e) perception of health professionals who struggled to offer support due to culture and language barriers. African immigrant mothers were positive about breastfeeding and willing to adopt best practice but faced challenges with cultural beliefs and lifestyle changes after migration. African mothers may benefit from more tailored support and information to improve exclusive breastfeeding rates. © 2020 The Authors. Maternal & Child Nutrition published by John Wiley & Sons, Ltd.In this series of articles, the board members of ChemSusChem discuss recent research articles that they consider of exceptional quality and importance for sustainability. This entry features Prof. A. W. Kleij, who discusses the use of electrosynthesis to advance the regioselective hydrocarboxylation of low-value olefins to afford high-value carboxylic acids using carbon dioxide as reagent. In particular, in a recent breakthrough contribution a general β-carboxylation of aromatic olefins is displayed and as such significantly expands state-of-the-art carboxylation chemistry. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Fifteen constituents, include one new lignan (schisandroside E, 1) and one new terpenoid (schisandenoid A, 2) as well as nine known lignans and four known terpenoids, were isolated from Schisandra chinensis leaves. The structures of compounds 1-2 were established by entirely meticulous spectroscopic analysis (NMR, MS, CD, IR and UV). All compounds were tested for cytotoxicity against MGC-803, Caco-2 and Ishikawa cell lines. Mocetinostat Some compounds showed strong cytotoxicity against these three cancer cell lines with IC50﹤1 μM. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.This longitudinal study (T1 n = 399; T2 n = 279) investigated the moderating role of work motivation in the relationship between job resources (control and recognition) and burnout. Overall, job recognition and control resulted in more burnout for employees with poor-quality work motivation (high controlled or low autonomous motivation). These results suggest that poor-quality motivation renders employees more vulnerable to certain resources in their work environment, as these job characteristics stimulate compensatory behaviours (e.g., overinvesting in one's job to boost one's sense of self-worth or to obtain others' approval), leading to energy depletion over time. © 2020 John Wiley & Sons, Ltd.Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorder with a worldwide prevalence of about 5%. The disorder is characterized by inattentive, hyperactive and impulsive behavior and is often comorbid with other neuropsychiatric conditions. Array comparative genomic hybridization (array-CGH) testing has been proved to be useful to detect chromosomal aberrations in several neuropsychiatric conditions including autism spectrum disorders (ASD) and intellectual disability (ID). The usefulness of array-CGH in the ADHD clinics is still debated and no conclusive evidence has been reached to date. We performed array-CGH in 98 children and adolescents divided in two similarly sized groups according to the clinical diagnosis (1) one group diagnosed with ADHD as primary diagnosis; (2) the other group in which ADHD was co-morbid with ASD and/or ID. We detected pathogenetic and likely pathogenetic copy number variants (CNVs) in 12% subjects in which ADHD was co-morbid with autism and/or intellectual disability and in 8.