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(3) The key sectors differ according to the three perspectives. For example, the energy production sector ranked first in production-based CO2 emissions (286.2 Mt), but heavy manufacturing ranked first in consumption-based CO2 emissions (146.3 Mt). This study recommends paying more attention to the abovementioned sectors, specifically concerning the transmission role of light manufacturing in freshwater withdrawal, and reducing energy consumption-intensive but low value-added exports (such as metal smelting and pressing). The findings highlight the need to consider multiple angles and elements to identify the key sectors and help decision makers better understand the relationships and flows among the industries.Aminoglycoside antibiotics (AAs) have been extensively applied in medical field and animal husbandry owing to desirable broad-spectrum antibacterial activity. Excessive AAs residues in the environment can be accumulated in human body through food chain and cause detrimental effect on human health. The establishment of highly specific, simple and sensitive detection methods for monitoring AAs residues is highly in demand. Aptasensor using aptamer as the biological recognition element is the efficient and promising sensing method for detection of AAs. In this review, we have made a summary of specific aptamers sequences against AAs. Subsequently, we provide a systematical and comprehensive overview of modern techniques in aptasensors for detection of AAs according to optical aptasensors as well as electrochemical aptasensors and further summarize their advantages and disadvantages to compare their applications. In addition, we present an overview of practical applications of aptasensors in sample detection of AAs. Moreover, the current challenges and future trends in this field are also included to reveal a promising perspective for developing novel aptasensors for AAs.With the development of industry and human society, more attention was paid for the toxic effects of organic pollutants that are closely related to human daily life. Previous studies mainly focused on the dose-response relationship and cytotoxic effects of pollutants to organisms，while little research focused on pollutant-protein interactions at molecular level. However, the binding of organic pollutants to biomolecules, especially proteins like transporters, membrane receptor and nuclear receptors, is often the first step of toxic effects. It can make a series of endocrine disrupting and genotoxic effects through cell signaling pathway by binding specific target proteins including serum albumin, thyroid transporter, estrogen receptor, androgen receptor, and aryl hydrocarbon receptor. Thus, the research of interactions between organic pollutants and proteins is helpful and necessary to understand the distribution, metabolism and toxicity mechanism of compounds in organisms at the molecular level. This paper reviewed the latest research progress of the interaction types of persistent organic pollutants (POPs), emerging pollutants and some other pollutants with targeted proteins. In addition, we summarized several main experimental techniques for studying pollutant-protein interactions including ultraviolet/visible absorption spectrometry (UV-vis), fluorescence, infrared spectrometry, circular dichroic spectra (CD), molecular docking and X-ray crystallography. This review contributes to the molecular mechanism of the interaction between organic pollutants and biomolecules.The issue of multirisk is coming under increasing scrutiny in the scientific literature and is of great concern for governments. Multirisk embraces different meanings domino and cascade effects, NaTech events and the consideration of several natural hazards and their interactions. Scientific production relating to multirisk has been growing over the last 15 years. This review, based on 191 articles, proposes a new way of analyzing and presenting bibliographic results by the use of a global textual analysis. This analysis leads to identify seven main themes of research in the literature three concern Domino Effects (46.6% of the articles), two are dedicated to the assessment of Multi-(hazard/vulnerability) Risk (28.7%), one deals with Natech issues (13.5%) and one concerns Cascade Effects in critical infrastructures (11.2%). A cross-issue analysis was performed on the basis of four criteria objectives, hazards, the elements at risk considered, and the approaches used or developed in the articles. It provides general lessons on these items and proposes themes for future research on the topic of multirisk.Fipronil is a broad-spectrum insecticide whose release in the environment damages many non-target organisms. This study evaluated the toxicity of fipronil at two biological levels using in vivo conditions and environmentally relevant concentrations the first based on two model organisms (aquatic invertebrate Daphnia magna and the unicellular freshwater alga Chlamydomonas reinhardtii) and a second based on three natural communities (river periphyton and freshwater and soil microbial communities). selleck The physicochemical properties of fipronil make it apparently unstable in the environment, so its behaviour was followed with high performance liquid chromatography (HPLC) under the different test conditions. The most sensitive organism to fipronil was D. magna, with median lethal dose (LC50) values from 0.07 to 0.38 mg/L (immobilisation test). Toxicity was not affected by the media used (MOPS or river water), but it increased with temperature. Fipronil produced effects on the photosynthetic activity of C. reinhardtii at 20 °C in MOPS (EC50 = 2.44 mg/L). The freshwater periphyton presented higher sensitivity to fipronil (photosynthetic yield EC50 of 0.74 mg/L) in MOPS and there was a time-dependent effect (toxicity increased with time). Toxicity was less evident when periphyton and C. reinhardtii tests were performed in river water, where the solubility of fipronil is poor. Finally, the assessment of the metabolic profiles using Biolog EcoPlates showed that bacteria communities were minimally affected by fipronil. The genetic identification of these communities based on 16S rRNA gene sequencing revealed that many of the taxa are specialists in degrading high molecular weight compounds, including pesticides. This work allows us to better understand the impact of fipronil on the environment at different levels of the food chain and in different environmental conditions, a necessary point given its presence in the environment and the complex behaviour of this compound.