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Findings indicated co-production equipped participants to function more effectively in their nursing roles; incorporating co-production into the development of future interventions may prove beneficial. The relative novelty of this approach, and the potential application of the findings to a diverse range of geographical and organisational settings, add to the utility of the findings.This study provided a systematic analysis on material flow and environmental impacts of a food waste (FW) bioconversion plant using black soldier fly larvae (BSFL), with a daily capacity of 15 tons of FW (wet weight). Food waste feed (FWF) used for BSFL bioconversion consisted of 80% FW (collected from households, restaurants, and canteens) and 20% rice hull powder. Material flow analysis conducted on a dry weight basis showed that 6% of FWF was transformed into BSF pre-pupae, 51% was stored in matured compost, and 43% was emitted to the air. Emissions of high environmental concern such as methane, nitrous oxide and ammonia (NH3) were sampled and quantified by laboratory analysis. The life cycle assessment revealed that the overall impact was 17.36 kg CO2-eq/t FW for global warming potential, 5.54 kg SO2-eq/t FW for acidification, 24.05 mol N-eq/t FW for terrestrial eutrophication, 0.54 kg N-eq NH3/t FW for marine eutrophication, and 0.18 kg PM2.5-eq/t FW of particulate matter up to 2.5 μm diameter. Moreover, emissions from post-composting, energy consumptions of drying and chemical fertilizer substitution ratio were detected by contribution analysis as the main contributors to those impacts. Finally, sensitivity analysis indicated that the substitution ratio of mineral fertilizer and protein feed as well as energy consumption were the most influential parameters, therefore control of the post-composting process of residual material should be closely monitored because it was responsible for significant environmental load caused by N-related emissions.Accounting for over 70% of global CO2 emissions, cities are major contributors to climate change. Acknowledging this, urban climate change adaptation and mitigation plans are increasingly developed to make progress toward enhancing climate resilience. While there is consensus that focusing on both adaptation and mitigation is necessary for addressing climate change impacts, better understanding of their interactions is needed to efficiently maximize their potentials. This paper, first, provides a bibliographic analysis to map existing knowledge regarding adaptation-mitigation interactions. This is done using methods such as bibliographic coupling, co-citation analysis, and co-occurrence analysis. Then, drawing on the literature, this study explores two types of interactions between adaptation and mitigation measures, namely co-benefits and synergies. These interactions are explored through analyzing evidence reported in the literature on different measures related to sectors such as energy, transportation, waste, water, green infrastructure, urban planning, and governance. selleck products Results of the bibliographic analysis show that there is a lack of research in the Global South. Results of the detailed content analysis show that many measures can provide co-benefits and synergies. Measures related to green infrastructure, buildings, energy systems, and, transportation are particularly capable of providing co-benefits. In addition, it was found that appropriate levels of density, promotion of public transportation, and urban greenery are measures that are more likely to provide synergistic benefits if combined with other adaptation and/or mitigation measures. This study highlights the need for more empirical research to better understand the magnitude of synergistic benefits between different measures.Cadmium is a common environmental pollutant that accumulates in the bone and kidneys and causes severe health and social problems. However, the effects of Cd on the occurrence of osteoporosis and its mechanism of action in this process are unclear. To test whether Cd-induced osteoporosis is mediated via P2X7/PI3K/AKT signaling, duck bone marrow mesenchymal stem cells (BMSCs) and bone marrow macrophage cells (BMMs) were treated with Cd for 5 days, and duck embryos were treated with Cd. Micro-CT analysis indicated that Cd-induced osteoporosis occurs in vivo, and histopathology and immunohistochemical analyses also revealed that Cd induced bone damage and the downregulation of osteogenic and bone resorption-related proteins. Cd exposure significantly inhibited the differentiation of BMSCs and BMMs into osteoblasts and osteoclasts in vitro, and promoted osteoblast and osteoclast apoptosis. Cd exposure significantly downregulated the P2X7/PI3K/AKT signaling pathway in vivo and in vitro, and inhibition of this signaling pathway significantly aggravated osteoblast and osteoclast differentiation. Cd exposure also upregulated the OPG/RANKL ratio in vivo and in vitro, further inhibiting osteoclast differentiation. These results demonstrate that Cd causes osteoporosis in duck by inhibiting P2X7/PI3K/AKT signaling and increasing the OPG/RANKL ratio. These results establish a previously unknown mechanism of Cd-induced osteoporosis.Challenges such as long-term cultivation and sludge floatation are common in flocculent sulfide-oxidizing autotrophic denitrification (SOAD) systems. The present study aims to optimize the granulation of SOAD sludge by mainly adjusting the reactor configuration and mixing mode. Three liquid-lift upflow reactors viz. a reactor equipped with a three-phase separator (Reactor A), a modified version of Reactor A equipped with a hydraulic regulator (Reactor B), and a reactor with a mounted baffle and intermittent mechanical mixing (Reactor C). These reactors were operated for more than 160 days. The results showed that dense and compact granules with 200 μm of diameter developed within 40 days and gradually increased to approximately 400 μm in Reactor C, which had a volatile suspended solids (VSS) concentration of 7500 mg VSS/L of sludge concentration; this Reactor C was also subject to modified reactor configuration and operating conditions. In comparison, filamentous granules formed in Reactor A due to a low substrate loading and granules formed in Reactor B but with significant biomass loss caused by sludge flotation.

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