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The proportion of last month drug users who had been excluded from school also increased significantly and there were increases in the proportion of polysubstance-users who had truanted and been excluded. The proportion of low SES alcohol users who had been excluded also increased significantly, but this change was very small. There was no evidence of substance use becoming more or less concentrated in one gender.

There is some evidence that smoking, illicit drug use and poly-substance use are becoming more concentrated in potentially at risk populations. There is limited evidence of concentration amongst young drinkers.

There is some evidence that smoking, illicit drug use and poly-substance use are becoming more concentrated in potentially at risk populations. There is limited evidence of concentration amongst young drinkers.The advent of soft robotics has led to great advancements in robots, wearables, and even manufacturing processes by employing entirely soft-bodied systems that interact safely with any random surfaces while providing great mechanical compliance. Moreover, recent developments in soft robotics involve advances in transparent soft actuators and sensors that have made it possible to construct robots that can function in a visually and mechanically unobstructed manner, assisting the operations of robots and creating more applications in various fields. In this aspect, imperceptible soft robotics that mainly consist of optically transparent imperceptible hardware components is expected to constitute a new research focus in the forthcoming era of soft robotics. Here, the recent progress regarding extended imperceptible soft robotics is provided, including imperceptible transparent soft robotics (transparent soft actuators/sensors) and imperceptible nontransparent camouflage skins. Their principles, materials selections, and working mechanisms are discussed so that key challenges and perspectives in imperceptible soft robotic systems can be explored.A family of recently developed devices, hydrogel ionotronics, uses hydrogels as ionic conductors, and uses hydrophobic elastomers as dielectrics. This development has posed a challenge integrate hydrogels and hydrophobic elastomers-in various manufacturing processes-with strong, stretchable, and transparent adhesion. Here, a multistep dip-coating process is described to enable hydrogel ionotronics of diverse configurations. In doing so, a hydrophobic surface is primed to let a hydrophilic precursor wet it, and then polymers of different layers are interlinked with covalent bonds. As a representative example, an ionotronic luminescent fiber that can be lengthened to ≈2.5 times its original length and keeps functioning after 10 000 cycles of stretching is fabricated. A luminescent fabric that displays movable pixels and other configurations is also demonstrated. The proposed method of fabrication expands the design space for hydrogel ionotronics.Silk sericin microcapsules loaded with horseradish peroxidase (HRP) are prepared through protein self-assembly in a green environment containing enzymes to protect liver cells from alcohol damage. Load content and release dynamics of HRP in sericin microcapsules are investigated. The role of HRP-loaded microcapsules in hydrogen peroxide (H2 O2 ) degradation is demonstrated using electrochemical method. Furthermore, the effect of the HRP-loaded microcapsules on cells and intracellular reactive oxygen species (ROS) level is evaluated using an alcohol damage model in vitro. Results show that HRP can be loaded effectively in the sericin microcapsules and can be released ROS-responsively from microcapsules. Cell survival rate increases after suffering from alcohol damage due to the presence of HRP-loaded microcapsule, and the active oxygen content in cells is maintained at a stable level even when it remained in an environment with high alcohol concentration. We believe that the internalized sericin microcapsules maintain HRP activity intracellularly, allow controlled HRP release within a host cell, and show excellent ability in antioxidative stress injury.The spatial resolution of microdissection-based analytical methods to detect ocular lens glucose uptake, transport and metabolism are poor, whereas the multiplexing capability of fluorescence microscopy-based approaches to simultaneously detect multiple glucose metabolites is limited in comparison with mass spectrometry-based methods. To better understand lens glucose transport and metabolism, a more highly spatially resolved technique that maintains the fragile ocular lens tissue is required. In this study, a sample preparation method for matrix-assisted laser desorption/ionisation imaging mass spectrometry (MALDI IMS) analysis of ocular lens glucose uptake and metabolism has been evaluated and optimised. Matrix choice, tissue preparation and normalisation strategy were determined using negative ion mode MALDI-Fourier transform-ion cyclotron resonance MS of bovine lens tissue and validation performed using gas chromatography-MS. VTX-27 molecular weight An internal standard was applied concurrently with N-(1-naphthyl)ethylenediamine dihydrochloride (NEDC) matrix to limit cracking of the fresh frozen lens tissue sections. MALDI IMS data were collected at a variety of spatial resolutions to detect both endogenous lens metabolites and stable isotopically labelled glucose introduced by ex vivo lens culture. Using this approach, initial steps in important metabolic processes that are linked to diabetic cataract formation were spatially mapped in the bovine lens. In the future, this method can be applied to study the dynamics of glucose uptake, transport and metabolic flux to aid in the study of diabetic lens cataract pathophysiology.Immigration status is an important mitigating factor in determining the provision of dialysis and kidney-related care. Immigrants make up the largest uninsured group in the country. For immigrants with end-stage kidney disease (ESKD), dialysis access varies by insurance type and by state, leading to great variability in the availability of kidney care. In some states, undocumented immigrants may only qualify for hemodialysis when critically ill (emergency hemodialysis), which is associated with higher mortality, hospital length of stay, and cost, in addition to an emotional burden on patients, their caregivers, and healthcare professionals. Barriers to effective care for immigrants with ESKD include immigration status, insurance access, and availability of pre-end stage kidney disease care, vascular access, and transplant. Effective strategies for improving dialysis care for immigrants include advocacy at the state and federal level, broadening definitions under Emergency Medicaid, and improving benefits for home therapies and transplantation options.