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The severity of gastrointestinal and psychological symptoms at baseline was similar between both groups. Globally, there was an improvement in all symptoms in both groups. The proportion of participants with severe baseline gastrointestinal symptoms or pathologic anxiety scores that showed improvement was significantly higher in Group A (74% vs 23%, p=0.005; 47% vs 8%, p=0.02; respectively). Symptoms were reassessed at 6 and 12 months after the intervention among those participants in Group A who attended ≥ 80% sessions, and sustained response was observed.

Group-consultations are useful and efficient to alleviate gastrointestinal and psychological symptoms in patients with functional gastrointestinal disorders.

Group-consultations are useful and efficient to alleviate gastrointestinal and psychological symptoms in patients with functional gastrointestinal disorders.In vitro studies which focus on cellular metabolism can benefit from time-resolved readouts from the living cells. pH and O2 concentration are fundamental parameters upon which cellular metabolism is often inferred. This work demonstrates a novel use of a ruthenium oxide (RuO x ) electrode for in vitro studies. The RuO x electrode was characterized to measure both pH and O2 using two different modes. When operated potentiometrically, continuous pH reading can be obtained, and O2 concentration can be measured chronoamperometrically. PD166866 chemical structure In this work, we demonstrate the use of the RuO x electrodes in inferring two different types of metabolism of human pluripotent stem cell-derived cardiomyocytes. We also show and discuss the interpretation of the measurements into meaningful extracellular acidification rates and oxygen consumption rates of the cells. Overall, we present the RuO x electrode as a versatile and powerful tool in in vitro cell metabolism studies, especially in comparative settings.Hydrocortisone, a natural glucocorticoid secreted by adrenal and extra-adrenal tissues, locally governs the transcription of genes involved in inflammation, immune response, metabolism, and energy homeostasis via binding to its cognate glucocorticoid receptor (GR). In this study, we show that modified hydrocortisone (HC16), a cancer-selective cytotoxic molecule, showed synergism in combination with drugs like Doxorubicin and docetaxel, self-assembled into vesicles, entrapped docetaxel and complexed with anti-cancer plasmid DNA for enhanced killing of cancer cells. These vesicles exhibited GR-mediated nuclear localization, delivery of the p53 gene, and also inhibited cell viability selectively in RKO, HCT15, and CT26 colon cancer cells but not in normal cells like CHO and HEK293T. Apart from exerting its own anti-cancer activity, the self-assembled HC16 vesicles loaded with docetaxel sensitized the cancer cells to its drug cargo by downregulating the drug metabolizing CYP3A4 gene. This indirectly reduces the rand N-cadherin, and increased the levels of pro-apoptotic activated caspases as compared to the pristine docetaxel-treated groups. The therapeutic package described herein is expected to find future use as a rational, multifaceted, GR-targeted approach for inhibiting colon tumor progression.Plants usually promote pollutant bioremediation by several mechanisms including modifying the diversity of functional microbial species. However, conflicting results are reported that root exudates have no effects or negative effects on organic pollutant degradation. In this study, we investigated the roles of ryegrass in phenanthrene degradation in soils using DNA stable isotope probing (SIP) and metagenomics to reveal a potential explanation for conflicting results among phytoremediation studies. Phenanthrene biodegradation efficiency was improved by 8% after 14 days of cultivation. Twelve and ten operational taxonomic units (OTUs) were identified as active phenanthrene degraders in non-rhizosphere and rhizosphere soils, respectively. The active phenanthrene degraders exhibited higher average phylogenetic distances in rhizosphere soils (0.33) than non-rhizosphere soils (0.26). The Ka/Ks values (the ratio of nonsynonymous to synonymous substitutions) were about 10.37% higher in the rhizosphere treatment amondation efficiency depends on the existence of active degraders that have competitive advantages in carbohydrate and fumaric acid metabolism.Singlet fission (SF) improves the power conversion efficiency of optoelectronic devices by converting high-energy photons into two triplet excitons. SF dynamics and efficiency (Φ) are controlled by various factors. Here, the effect of planarity and length of the bridge in pentacene dimers on the intramolecular SF (iSF) process was investigated by synthesizing the dimers connected by bridges having fluorene (FL-PD, planar), methyl-substituted biphenyl (MBP-PD, twisted), and diphenyl acetylene (DPA-PD, longer) groups and characterizing their excited-state relaxation dynamics using nanosecond and femtosecond pump-probe spectroscopy. Transient absorption studies reveal that iSF dynamics of FL-PD having a planar bridge are ∼787 times faster (187 ps) and exhibit higher Φ (198%) by feasible electronic coupling, compared to MBP-PD possessing a twisted bridge showing a low Φ of ∼16%. However compared to FL-PD, iSF dynamics of DPA-PD with an increase of bridge length are slower by an order (1.09 ns) and show comparable Φ of 185% through extended conjugation. Thus, the planarity and length of the bridge in pentacene dimers control the rate and efficiency of the iSF process.Thirteen new linear terpenes, including 11 rare acyclic manoalide derivatives (1-11), one polyprenylphenol derivative (12), and one polyprenylbenzaldehyde derivative (13), together with three known compounds (14-16) were isolated from the sponge Luffariella variabilis collected in the South China Sea. The planar structures were resolved by NMR and MS analyses, while the absolute configurations were fully elucidated by NOESY experiments, combined with experimental and calculated ECD spectra, acetal formation, empirical rules of 1H and 13C NMR shifts, DP4+ probability analyses, and Mosher's method. Compounds 1-7, 10, and 13 demonstrated cytotoxic activities against several human cancer cell lines with IC50 values ranging from 2 to 10 μM.