Mckinneygundersen0573

Respiratory syncytial virus (RSV) is the agent that causes more hospitalizations and deaths due to lower acute respiratory infection. Its distribution is widespread, and almost every child has been infected by the age of two years. Different risk populations have been identified preterm newborns (NB), children with congenital heart disease, bronchopulmonary dysplasia, Down syndrome, cystic fibrosis, asthmatics, neuromuscular diseases, among others. However, preterm NBs, children with congenital heart disease or bronchopulmonary dysplasia show higher rates of hospitalization and death from RSV. In the late 90s, monoclonal antibodies against RSV were developed, with demonstrated efficacy and safety for the prevention of RSV hospitalizations in these populations. Currently, the American Academy of Pediatrics recommends this therapy for the prevention of severe infection in the population at higher risk. Economic evaluations have been conducted to determine the effectiveness of immunization, resulting favorable for palivizumab. Immunization in Mexico has resulted cost-effective in NBs under 32 gestation weeks. Mexican authorities should discuss the inclusion of palivizumab in their clinical guidelines.Background Childhood obesity is a global problem, causing social and psychological damage, as well as physical health risks. This study estimated the occurrence of body image dissatisfaction in primary schoolchildren aged 9-13 years and investigated its association with obesity and other factors. Methods A cross-sectional study was conducted, for which 533 students attending three public primary schools in Acapulco were recruited. Students completed a facilitated self-administered questionnaire about their age, sex, socioeconomic level, body image satisfaction, and perception of their parents' body image. We registered anthropometry of the students and calculated body mass index (BMI). We examined the associations of BMI category and other factors with body image dissatisfaction, calculating the cluster-adjusted odds ratio and 95% confidence intervals. Results From the total number of participants, 75% (181/243) of girls and 73% (170/232) of boys were dissatisfied with their body image and wanted a slimmer body. Azaindole 1 About half were overweight or obese 45% (121/271) of girls and 52% (135/262) of boys. Overweight or obese children were much more likely to be dissatisfied with their body image (cluster adjusted 6.73; 95% CI 5.42-8.36). No other factors were significantly associated with body image dissatisfaction. One-third of the girls (32%, 86/271) and 17% (45/261) of the boys reported an underweight desired body image. Conclusions The high level of obesity is a cause for concern and an even higher level of body image dissatisfaction as well. The high dissatisfaction among children suggests that boys, as well as girls in Mexico, may now be subjected to intense social pressure about desirable body image.Incontinentia pigmenti is an X-linked genodermatosis generally lethal in males; thus, it presents almost exclusively in females. It is caused by a loss-of-function mutation in the IKBKG (inhibitor of kappa polypeptide gene enhancer in B cells, kinase gamma) gene that prevents the NFкβ (nuclear factor kappa-light-chain-enhancer of activated B cells) protein from migrating to the nucleus to begin the transcription of factors that amplify the immune response and prevent apoptosis. Consequently, mutant cells become vulnerable to apoptosis when exposed to cytokines and, in turn, lead to vaso-occlusion and ischemia of tissues, such as the skin, the central nervous system and the retina. Dermatological lesions are characteristic and occur in 100% of patients; they are distributed along Blaschko lines, which follow the pattern of migration of skin cells in embryogenesis. The cutaneous manifestations follow a sequence of four phases since birth vesicular, verrucous, hyperpigmented and hypopigmented. These lesions are relevant for the disease because they guide the clinician towards the diagnosis. Additionally, they are accompanied by neurological abnormalities, such as seizures, and multiple ophthalmological manifestations, such as retinal detachment. Incontinentia pigmenti patients with no clinically significant ophthalmic or neurological compromise have a good prognosis and a normal life expectancy. The abnormalities present are permanent, which can be a cause of concern for the patients.Background Retinopathy of prematurity (ROP) is the principal cause of blindness during childhood. The objective of this study was to analyze the frequency of ROP and risk factors associated with ROP in a cohort of very low birth weight infants. Methods A cases (ROP) and controls (no ROP) study of infants less than 1500 g was conducted. Perinatal and neonatal variables were analyzed. For the statistical analysis, χ2 test, Student's t-test and Mann-Whitney's U-test were used. Results For the study, 282 neonates were included 152 (53.9%) with ROP and 130 (46.1%) without ROP. The most frequent stages observed were stage 1 and 2, with 139 (91.4%) patients, and stages 3 to 5, with only 13 patients (8.5%). In those neonates with ROP compared with neonates without ROP, the birth weight was less (902.7 vs. 1037.9 g) and the difference was significant (p less then 0.0001). Also, the difference with gestational age (28.2 vs. 29.6; p less then 0.0001), total ventilation days (32.8 vs. 16.1; p less then 0.00001) and total oxygen days (87.7 vs. 62.6; p less then 0.0001) was significant in neonates with ROP and neonates without the disease. Bronchopulmonary dysplasia, intraventricular hemorrhage and late onset sepsis were significant with patients with ROP. Conclusions The frequency of ROP reported here is higher than the reported in Mexican population, with less cases of severe ROP. The neonatal surveillance in babies with less birth weight and gestational age is important to decrease the incidence of ROP.PRéCIS Overhead mounted spectral-domain optical coherence tomography enables high quality imaging of the optic nerve and macula in childhood glaucoma and is particularly useful when standard tabletop optical coherence tomography has failed or is not possible. Purpose Tabletop optical coherence tomography, integral to adult glaucoma management, can be limited in childhood glaucoma patients due to young age, poor cooperation, and/or technical challenges. To address these imaging difficulties, we determined the feasibility and quality of an overhead mounted unit in childhood glaucoma. Secondary aims included evaluation of peripapillary retinal nerve fiber layer, parafoveal total retinal thickness, and parafoveal ganglion cell complex thickness. Materials and methods Children and adults with a diagnosis of childhood glaucoma were imaged with overhead mounted spectral-domain optical coherence tomography as part of a prospective cross-sectional study. Participants had poor quality or unobtainable tabletop optical coherence tomography and were scheduled for an examination under anesthesia and/or surgery as part of standard care.