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infection should be excluded when SLE patients, especially if on long-term immunosuppressants, present withfever, cough, lymph node enlargement, gastrointestinal symptoms, and rash. Controlling the lupus and timely antifungal treatment can improve the outcomes ofSLE patients with
infection.
T. marneffei infection should be excluded when SLE patients, especially if on long-term immunosuppressants, present with fever, cough, lymph node enlargement, gastrointestinal symptoms, and rash. Controlling the lupus and timely antifungal treatment can improve the outcomes of SLE patients with T. marneffei infection.
The emerging of the novel coronavirus in Wuhan, China, since the time declared as a public health emergency of international concern, its impact on the lives of people is negatively substantial. Despite the vulnerability of all ages from the pandemic, evidence showed that elder people are at high-risk for adverse outcomes from coronavirus disease-19. Therefore, this study aimed to assess the knowledge, attitude, and practice of high-risk age groups to coronavirus disease-19 prevention and control in Korem district, Tigray, Ethiopia.
A community-based cross-sectional study was conducted among high-risk age groups from April 2 to May 9/2020 in Korem district, Tigray, Ethiopia. A total of 422 study participants were selected using a simple random sampling technique. The collected data were entered into Epi-data version 3.1 and exported to SPSS version 22.0 for analysis. Multivariable analysis was done using linear regression after checking collinearity, and a p-value of less than 0.05 was considered significoughly appropriate but the preventive practices and attitude towards coronavirus disease-19 were found less and inappropriate. Since no proven medicine is invented yet, so maximizing knowledge, increasing behavioral change, and strengthening preventive practices towards coronavirus disease-19 prevention and control is the appropriate solution.
The rapid spread of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae among food handlers is a public health concern and has become a serious world threat.
and
are the predominant ESBL-producing Enterobacteriaceae. This study aimed to assess the magnitude of ESBL producing
and
isolated from the stool of food handlers in the Dilla University Student Cafeteria.
A cross-sectional study was conducted from November to September 2018/2019. A total of 220 stool samples were cultured on MacConkey agar and a series of biochemical tests were performed for the identification of bacterial species. Double-disk synergy method was used for the detection of ESBL-producing strains.
The rate of fecal carriage of
and
among the food handlers of the current study was 66.4%, of which 81.5% was
, while 18.5% was
. Of the total bacterial isolates, 25.3% were confirmed to be positive for ESBL production, of which 19.9% was
, while 5.5% was
. ESBL-producing fecal carriage showed high ressporins and non-β-lactam antibiotics is more common among ESBL producers. Detecting ESBL-producing organisms has a remarkable importance in clinical decision-making. Hence, a coordinated effort should be implemented for the prevention and control of the disease.Antiretroviral drug resistance has become a major threat to the adequate management of human immunodeficiency virus (HIV) infection, but little attention has been paid to the spread and evolution of drug-resistant strains in the family. Here, we described a case of transmitted as well as acquired HIV drug resistance among a father, mother and infant. Epidemiological data were obtained retrospectively. Drug resistance mutations (DRMs) of three patients were tested using a validated In-house Sanger-based sequencing (SBS) method and the Vela next-generation sequencing (NGS) platform. Gene evolution analysis was also performed. According to the epidemiological history and phylogenetic data, in late pregnancy of the mother, the infant's father transmitted HIV-1 to her, and then the mother to the baby, leading to the transmission of V106I as a common mutation of three persons. The mutant frequency was 99.57% (father), 95.38% (mother) and 99.73% (infant), respectively. Mother also acquired K101E (41.03%), K103N (27.56%) and minor mutation of V106M (4.30%) after improperly discontinuing antiretroviral regimen of lamivudine (3TC), tenofovir (TDF) and efavirenz (EFV). Zongertinib chemical structure Such acquired mutations increased the drug resistance scores on non-nucleoside reverse transcriptase inhibitors (NNRTIs) doravirine, EFV, etravirine, nevirapine and rilpivirine from 10, 0, 10, 10 and 10 to 65, 135, 25, 150 and 55, respectively. Therefore, sexually transmitted diseases, especially DRMs of HIV-1 in families, are of concern and draw attention to the need for enhanced drug-resistance prevention efforts, and accurate surveillance by more sensitive methods in complicated cases.
Ethiopia has taken strict preventive measures against COVID-19 to control its spread, to protect citizens, and ensure their wellbeing. Employee's adherence to preventive measures is influenced by their knowledge, perceived susceptibility, severity, benefit, barrier, cues to action, and self-efficacy. Therefore, this study investigated the predictors of COVID-19 prevention practice using the Health Belief Model among employees in Addis Ababa, Ethiopia, 2020.
Multicentre cross-sectional study design was used. A total of 628 employees selected by systematic sampling method were included in this study. Data were collected using a pretested self-administered questionnaire. Summary statistics of a given data for each variable were calculated. Logistic regression model was used to measure the association between the outcome and the predictor variable. Statistical significance was declared at p-value<0.05. Direction and strength of association were expressed using OR and 95% CI.
From a total of 628 respondenntion practice.
The proportion of employees with poor COVID-19 prevention was high. Income, perceived barrier, cues to action, and self-efficacy were significantly associated with COVID-19 prevention practice.
