Atkinsonbright6700

We will perform statistical analysis using RevMan 5.3 software.

This study will provide a detailed summary of exist evidence related to the effectiveness and safety of HEEPSWT for ESFHO.

The results of this study synthesize the evidence regarding the HEEPSWT for ESFHO, which may help to guide clinical management in the future.

INPLASY202060055.

INPLASY202060055.Serums were collected from people to assess whether polio immunity level was high enough to satisfy the polio vaccine immunization switch in Chongqing.People in 7 age groups ( less then 1 year, 1-2 years, 3-4 years, 5-6 years, 7-14 years, 15-19 years, ≧20 years) were randomly selected in 3 areas by different geographical features in 2015. Peripheral venous blood samples were obtained and assays to detect poliovirus (PV) -neutralizing antibodies were performed. Acute flaccid paralysis (AFP) data was collected from 2012 to 2016 in Chongqing to evaluate the performance of AFP surveillance system by indicator analysis.A total of 636 people were tested for PV neutralization antibodies (NA). Overall NA seroprevalence for PV1, PV2 and PV3 were 93.40%, 96.38% and 91.82%, and geometric mean titers (GMTs) were 61.14, 66.78 and 21.47, respectively. GMTs and NA seroprevalence for PV1, PV2 and PV3 in older people were lower than young people. There were significant differences in seroprevalences of PV1 and PV3 among geographic areas (P  less then  .05) in Chongqing.High seroprevalence for PV1, PV2, and PV3 and qualified capability for monitoring AFP cases showed that the polio eradication program has made positive achievements in Chongqing and established a stable base for a polio vaccine immunization switch. Nevertheless, GMTs were negatively associated with age in the geographic districts with poor economical features, which will increase the risk of emergence of vaccine-derived PV after polio vaccine switch. More than 1 dose of inactivated polio vaccine should be introduced into the polio vaccine schedule, and the supplementary immunization of polio should still be annually carried out after polio vaccine switch, especially among elder children and the adults.Vitiligo is a chronic skin condition lack of melanocytes. However, researches on the aetiology and pathogenesis of vitiligo are still under debate. This study aimed to explore the key genes and pathways associated with occurrence and development of vitiligo.Weighted gene coexpression network analysis (WGCNA) was applied to reanalyze the gene expression dataset GSE65127 systematically. Functional enrichments of these modules were carried out at gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), gene set variation analysis (GSVA), and gene set enrichment analysis (GSEA). selleck chemicals Then, a map of regulatory network was delineated according to pivot analysis and drug prediction. In addition, hub genes and crucial pathways were validated by an independent dataset GSE75819. The expressions of hub genes in modules were also tested by quantitative real-time polymerase chain reaction (qRT-PCR).Eight coexpressed modules were identified by WGCNA based on 5794 differentially expressed genes of vitiligo. Three modu and predicting potential diagnostic biomarkers and therapeutic targets.

Traditional Chinese medicine (TCM) has gradually drawn the attention of clinicians as an alternative for Primary Liver Cancer (PLC), is based on the theory of syndrome differentiation. However, owing to the lack of evidence-based medical evidence, the authors designed this protocol to evaluate TCM's effectiveness and safety.

Seven electronic databases will be searched from inception to Aug. 2020. Two of us will independently identify randomized controlled trials, extract the data and assess the risk of bias. The meta-analysis will be conducted with the Review Manager 5.3 software according the heterogeneity of eligible studies. Further, we will use the grading of recommendations assessment, development, and evaluation to evaluate the evidence quality.

This study will demonstrate an evidence-based review of TCM for PLC.

The study will provide clear evidence to assess the effectiveness and side effects of TCM for PLC.

PROSPERO CRD 42020173748.

PROSPERO CRD 42020173748.

A sudden onset of anosmia has been recently recognized as a symptom of coronavirus disease (COVID-19).

Here, we describe a case of complete anosmia in a young male with COVID-19. Although he had fever and odynophagia, no abnormalities were observed in his nasopharyngeal mucosa, suggesting that his anosmia resulted from olfactory neuropathy.

COVID-19 was confirmed by RNA detection in nasopharyngeal swab specimen.

The patient received olfactory training and B complex vitamins.

On day 30, the patient reported complete recovery of his sense of smell.

As early diagnosis is fundamental to control the spread of COVID-19 infection, we emphasize that anosmia identified in febrile cases during the COVID-19 epidemic may be a symptom indicative of the disease. Moreover, COVID-19-related anosmia can be completely reversible.

As early diagnosis is fundamental to control the spread of COVID-19 infection, we emphasize that anosmia identified in febrile cases during the COVID-19 epidemic may be a symptom indicative of the disease. Moreover, COVID-19-related anosmia can be completely reversible.To retrospectively evaluate the efficacy and safety of unilateral and bilateral percutaneous balloon kyphoplasty (PKP) in the treatment of osteoporotic thoracolumbar burst fractures.Retrospectively collected clinical data of 138 patients with osteoporotic thoracolumbar burst fractures who underwent unilateral (n = 70) and bilateral (n = 68) PKP in our hospital from March 2015 to December 2018. The general conditions, operation time, radiation exposure time, intraoperative blood loss, bone cement dosage, hospitalization expenses, and complications were collected from the two groups. Visual analog scale (VAS) values, Cobb's angle changes, average vertebral height changes, and Oswestry Dysfunction Index (ODI) values before treatment, 1 month, and 6 months after treatment were collected.There was no significant difference in gender (male 28 vs 22; female 42 vs 46) and age (70.25 ± 7.10 vs 69.82 ± 8.20, P > .05) distribution between the two groups. The VAS score (7.38 ± 1.34 vs 2.52 ± 0.99, P  .05) between the two groups.