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210) did not differ between groups. There were 14 (0.5%) deaths < 30 days postoperatively and the risk was similar across BMI strata (P=0.448). Model-estimated changes in average BMI at 10 years post procedure showed stratum-specific increases ranging from 0.60 to 1.56 kg/m

. During a median (IQR) follow-up of 7.2 (3.2-13.3) years, higher BMI was associated with reduced survival after adjusting for baseline covariates (P=0.001).

Septal myectomy is safe and effective in HCM patients with obesity, but risk of late mortality increased with increasing BMI. Attention to risk factor management through weight loss may improve late results after SM.

Septal myectomy is safe and effective in HCM patients with obesity, but risk of late mortality increased with increasing BMI. Attention to risk factor management through weight loss may improve late results after SM.

Esophagectomy is associated with postoperative delirium but its pathophysiology is not well defined. We conducted this study to measure the relationship among serum biomarkers of inflammation and neuronal injury and delirium incidence and severity in a cohort of esophagectomy patients.

Blood samples were obtained from patients at preoperative and postoperative days 1 and 3, and analyzed for S100 calcium-binding protein B, C-Reactive Protein, interleukins 8, 10, tumor necrosis factor-alpha, insulin like growth factor 1. Delirium was assessed using Richmond Agitation Sedation Scale and Confusion Assessment Method for Intensive Care Unit twice daily. Delirium severity was assessed using Delirium Rating Scale Revised-98 once daily.

Samples from 71 patients were included. Preoperative biomarker concentrations were not associated with postoperative delirium. Significant differences in change in concentrations from preoperative to postoperative day 1 were seen in interleukin-8 (delirium 38.6 interquartile range (IQR) 29.3, 69.8; no delirium 24.8 IQR 16.0, 41.7, p=0.022), and interleukin-10 (delirium 26.1 IQR 13.9, 36.7; no delirium 12.4 IQR 7.7, 25.7, p=0.025). Greater postoperative increase in S100 calcium-binding protein B (Spearman r=0.289, p=0.020) and lower levels of Insulin-like Growth Factor 1 were correlated with greater delirium severity (Spearman r=-0.27, p=0.040). Greater CRP change quartiles were associated with higher delirium incidence adjusting for severity of illness (OR=1.68, 95% CI 1.03,2.75, p=0.037) or comorbidities (OR=1.70, 95% CI 1.05,2.76, p=0.030).

Differences in change in serum CRP, IL-8 and IL-10 concentrations were associated with postoperative delirium suggesting biomarker measurement early in the postoperative course is associated with delirium.

Differences in change in serum CRP, IL-8 and IL-10 concentrations were associated with postoperative delirium suggesting biomarker measurement early in the postoperative course is associated with delirium.

Psychiatric comorbidities (PC) have been associated with poor surgical outcomes in several malignancies. However, the impact of PC on surgical outcomes for non-small cell lung cancer (NSCLC) remains largely unknown.

NSCLC patients who underwent pulmonary resection at a single institution between 2006-2017 were included. Presence of preoperative PC was identified by documented diagnostic codes. Demographic, histopathologic, perioperative, and survival data were analyzed. Categorical variables were compared using chi-squared or Fisher's exact test. Overall and disease-free survival were analyzed using Kaplan-Meier method. Univariable and multivariable logistic regression analyses were performed for 30-day readmission.

Among 2907 patients, PC were present preoperatively in 180 (6%), including 130 (72%) anxiety, 52 (29%) depression, 28 (16%) adjustment disorder, 16 (9%) alcohol abuse, 8 (4%) sleep disorder, and 3 (2%) schizophrenia. Patients with PC were younger, with fewer cardiovascular complications. Theidentify reasons for increased risk of readmission for patients with PC and validate these findings in other settings.

Various adhesion molecules including intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) have been shown to play a role in inflammation as well as contribute to tumor progression and prognosis. We hypothesized that gastroduodenal reflux upregulates ICAM-1 and VCAM-1 expression in the distal esophagus, serving as possible early markers of pathologic esophageal disease.

Normal human esophageal epithelial cells (HET1A), Barrett's cells (CPB), and esophageal adenocarcinoma cells (FLO1 and OE33) were treated with deoxycholic acid (DCA) at increasing concentrations for 24 hours. Adhesion molecule expression was assessed using immunoblotting. A surgical mouse reflux model was generated by performing a side-to-side anastomosis between the gastroesophageal junction and the first portion of the duodenum (duodeno-gastroesophageal anastomosis, DGEA). Esophageal sections were evaluated using H&E staining, immunohistochemistry, and immunofluorescence.

DCA induced a significanICAM-1 is noticeably upregulated without a concomitant increase in VCAM-1. These findings identify ICAM-1, but not VCAM-1, as a potential player in early esophageal disease developing from chronic reflux exposure.

The 2020 interview cycle for cardiothoracic fellowships was affected by the coronavirus-19 pandemic. Many programs shifted from in-person to virtual interviews. We evaluated applicant perceptions of the various formats.

All 2019-2020 cardiothoracic fellowship applicants received an electronic survey after completion of the match process. The survey assessed number of in-person/virtual interviews completed, perception of efficacy and likelihood of ranking a program based on format, and strengths/inadequacies of virtual interviews.

Response rate was 36% (48/133). Seventy-three percent (35/48) of respondents interviewed with more than 10 programs. this website Fifty-two percent (25/48) of respondents were able to schedule additional interviews once virtual formats were available. A slight majority (56%, 27/48) ranked a program at which they had an in-person interview as their first choice. Interviewing at more than 10 programs was associated with an increased likelihood of successfully matching at a program (p = 0.02).