Krusekloster5552

Upper respiratory infections and bronchiolitis are among the most common pathologies in childhood. In paediatric patient care, the nasal lavage technique is widely used as it is recommended in various sinus pathologies.

To synthesize the available evidence on nasal lavage technique in paediatric patients.

Literature search in MEDLINE, EMBASE, CINAHL and COCHRANE PLUS databases, using the descriptors paediatrics, respiratory tract infection, bronchiolitis, nasal lavage.

11 articles were selected due to relevance and specificity. In the documents, the recommendations are structured in five sections regarding the LN technique.

We can recommend, based on scientific evidence, the use of sterile isotonic saline, low positive pressure with wide volumes using a disposable syringe. In the future, the aspects of volume to be used, material and position of the patient regarding the technique should be studied in depth.

We can recommend, based on scientific evidence, the use of sterile isotonic saline, low positive pressure with wide volumes using a disposable syringe. In the future, the aspects of volume to be used, material and position of the patient regarding the technique should be studied in depth.

Therapeutic drug monitoring (TDM) through measurement of infliximab (IFX) trough levels and antibodies to infliximab (ATI) is performed to guide IFX intensification strategies and improve its efficacy. We conducted this study to explore the relationship between clinical and endoscopic/radiological remission and IFX and ATI levels in patients with inflammatory bowel disease (IBD) treated with IFX and to evaluate the appropriateness of treatment decision post TDM.

This was a cross-sectional study of a cohort of adult patients with IBD. Serum IFX trough concentrations and ATI were measured.

A total of 129 patients [104] with ulcerative colitis (UC) and 25 with Crohn's disease (CD)] were included in this study, of whom 61.2% were men. The mean disease duration was 6.7years, and 72% of patients with UC had extensive colitis. The mean serum IFX trough level was 4.1µg/mL; the IFX trough levels were subtherapeutic in 75 patients (58%), therapeutic in 37 patients (29%), and supratherapeutic in 17 patients (13%). Positivity to ATI was found in 16 patients (12.4%). Only 43 patients (33.3%) underwent an appropriate change in therapy after TDM, patients with penetrating CD disease had low IFX levels and higher C-reactive protein levels at 12months before TDM.

Patients with IBD with therapeutic IFX levels tend to have increased endoscopic/radiological remission rates. However, an appropriate change in management based on TDM was absent in the majority of patients, potentially reflecting the need to have a dashboard to support and guide clinicians in decision-making.

Patients with IBD with therapeutic IFX levels tend to have increased endoscopic/radiological remission rates. However, an appropriate change in management based on TDM was absent in the majority of patients, potentially reflecting the need to have a dashboard to support and guide clinicians in decision-making.

To assess the entrance surface dose (ESD) of pediatric chest X-ray examinations in order to establish a diagnostic reference levels (DRLs) in Togo.

The study was carried out in 13 radiology departments within the 6 health regions of the country. This is a descriptive cross-sectional study relating to the dosimetric assessment of the skin of children aged from 0 to 15 years during chest X-ray examinations. The assessment was made by the empirical formula calculation of the entrance surface dose (ESD=0.15 × (U/100)

× Q × (1/FSD)

) and with the Internet Dose Calculation Module (MICADO) software online. Statistical assessment was performed using IBM SPSS 21 software.

Our sample numbered 390 with a sex ratio of 1.3 and predominantly male. Examinations performed with the analog radiography units were more irradiating (0.14mGy) than ones performed with digital detectors (0.12mGy). The mean dose calculated with MICADO was low (Avg.=0.12mGy) compared to that calculated with the theoretical method (Avg.=0.16mGfective measures must be put in place to optimize the doses delivered to children during chest X-ray examinations.

The antiviral resistance of cytomegalovirus (CMV) infections is associated with mutations in the CMV UL54 and UL97 gene regions and is a serious problem in immunocompromised patients. However, the molecular epidemiology of UL54 and UL97 in Taiwan is unclear.

We conducted a retrospective study of patients with CMV infections between January and December 2016 in two tertiary hospitals, one regional hospital in Taiwan. CMV DNAemia was confirmed by elevated CMV DNA titers. Then the regions of the UL54 and UL97 mutations were amplified by PCR and sequenced.

Of 729 patients with CMV syndrome, 112 CMV DNAemia patients were enrolled. Twelve novel variants in UL54 (P342S, S384F, K434R, S673F, T754M, R778H, C814S, M827I, G878E, S880L, E888K, and S976N) and one novel variant in UL97 (M615T) were discovered. UL97 antiviral resistance mutations (L595S, M460I, and M460V) were found in four patients (3.6%). In the drug resistance strains, the mutation events occurred after 83-150 days of therapy, and drug resistance with refractory CMV infection is recommended.Among 275 patients with COVID-19, we found that median blood zinc level was significantly lower in patients with poor clinical outcome (N = 75) as compared to patients with good clinical outcome (N = 200) (840 μg/L versus 970 μg/L; p less then 0.0001), suggesting that zinc supplementation could be useful for patients with severe COVID-19.Intussusception is a rare yet potentially life-threatening complication following Roux-en-Y gastric bypass (RYGB). Multiple case reports have described this complication, and recently, several retrospective studies have been published describing the surgical treatment of intussusception. The aim of this study was to determine the incidence of intussusception following RYGB and provide insight into outcomes of subsequent operative treatment. A systematic search was performed using the PubMed and Cochrane databases. Article selection was performed using the preferred reporting items for systematic reviews and meta-analyses criteria, and selecting articles describing the incidence of intussusception following RYGB. Data was pooled only when 3 or more comparable studies reported on the same outcome. The incidence of intussusception and outcomes of subsequent treatment were analyzed. Furthermore, all published case reports describing intussusception following RYGB were analyzed. find more A total of 74 studies published between 1991 and 2020 were included, describing 191 patients who underwent RYGB and developed intussusception.