Napierosman7839
Preterm infants have a higher risk of showing visuospatial memory impairment, the function that allows to encode and remember visual and spatial information. It has been studied in late childhood in preterm children. Studies on visuospatial memory throughout the first 2 years of life are still scarce. Behavior, temperament, and overall cognition could be altered in preterm children affecting memory performance. Therefore, the main aim of this study was to evaluate short-term and visuospatial working memory performance in a preterm sample followed longitudinally at 12, 15, 18, and 22 months (N = 15), and compare their performance with that of full-term children (N = 65). The secondary aim was to analyze the course of mnesic development in preterm infants and relate their memory performance to other cognitive abilities and behavioral tendencies. Assessment included previously published tasks and an experimental paradigm. Results showed that preterm children scored lower than full-term children on visuospatial short-term and working memory at 12 and 22 months of age, although these results varied depending on the memory test used. Preterm children's memory results showed that these skills improve in this population between the first and second year of life. Finally, memory performance was directly associated with the level of cognitive development and the presence of proactive behaviors, while being inversely correlated with the presence of disruptive behaviors and a difficult temperamental style. These preliminary findings suggest that it is possible to detect visuospatial memory difficulties in the preterm population before the age of two.Although isokinetic strength testing is commonly used in hamstring strain injury (HSI) rehabilitation and prevention, research findings concerning its predictive value remain inconclusive. Existing research focuses on peak torque (PT) and angle of PT, not analysing the torque behaviour throughout the testing range of motion (ROM). This study intended to assess the value of isokinetic curve evaluation in association with HSI. A sample of 116 male football players with and without a recent HSI history was submitted to bilateral isokinetic assessment of the knee and hip muscles. Raw isokinetic data were filtered and normalized prior to curve analysis submission in MATLAB. Torque development of each muscle group throughout the entire testing ROM was assessed using HSI history as an independent variable. Curve analysis revealed significant differences in torque behaviour in function of injury history. Players with an HSI history demonstrated significantly stronger concentric knee flexion and extension, eccentric knee extension and concentric hip extension patterns compared to the controls and their uninjured limb. HSI history was also associated with lower concentric hip flexion torques and lower mixed HQ ratios compared to the control group and their contralateral limb. HSI history was associated with altered knee and hip muscle strength profiles, potentially due to isolated focus on local strength training in rehabilitation or mechanisms of neuromuscular inhibition. Because the differences in torque amplitude were range-dependent and did not systematically concur with the point of PT achievement, isokinetic strength evaluation should most probably be conducted using curve analysis.Abstract This study compared neuromechanical characteristics of voluntary (maximum voluntary contraction (MVC) peak torque, rate of torque development (RTD), voluntary activation (VA)) and electrically stimulated contractions (peak torque, RTD) when performed under the same temperature conditions. Twelve physically active males performed two isometric MVCs of the quadriceps muscle group in an isokinetic dynamometer. The MVCs were performed after lower limb submersion for 20 min in hot (40°C) or cold (10°C) water. A control MVC was performed in ambient room temperature (17 ± 0.7°C). Electrical twitches were delivered at rest pre-MVC (Unpotentiated), during the plateau phase of the MVC (Superimposed) and post-MVC (Potentiated). PMSF Peak torque for MVC, Unpotentiated and Potentiated was recorded. RTD was calculated for the MVC (at 50, 100, 150, 200 ms and peak torque time points), Unpotentiated and Potentiated twitches, while VA (using the central activation ratio method) was calculated. There was no significant change between conditions in MVC peak torque, MVC RTD, VA and (averaged) twitch peak torque (p > 0.05). Twitch RTD for the hot condition (1025.0 ± 163.0 N·m·s-1) was significantly higher (p = 0.003) than control (872.3 ± 142.9 N·m·s-1). In conclusion, environmental temperature changes, in the range examined, do not affect the ability to generate maximum torque or any of the RTD parameters in maximum voluntary isometric contractions. In contrast, increased heat results in higher RTD in electrically stimulated contractions, most likely induced by reduced contraction time. This has practical implications for the use of electromyostimulation for injury prevention.
Inflammation is one of the hallmarks of cancer. Tumor-associated inflammatory response plays a crucial role in enhancing tumorigenesis. This study aimed to establish an effective predictive nomogram based on inflammation factors in patients with advanced non-small cell lung cancer (NSCLC).
We retrospectively evaluated 887 patients with advanced NSCLC between November 2004 and December 2015 and randomly divided them into primary (n = 520) and validation cohorts (n = 367). Cox regression analysis was used to identify prognostic factors for building the nomogram. The predictive accuracy and discriminative ability of the nomogram were determined using a concordance index (C-index), calibration plot, and decision curve analysis and were compared to the TNM staging system.
The nomogram was established using independent risk factors (
< 0.05) age, TNM stage, C reaction protein-to-albumin ratio (CAR), and neutrophils (NEU). The C-index of the model for predicting OS had a superior discrimination power compared to that of the TNM staging system both in the primary [0.711 (95% CI 0.675-0.747) vs 0.531 (95% CI 0.488-0.574),
< 0.01] and validation cohorts [0.703, 95% CI 0.671 -0.735 vs 0.582, 95% CI 0.545-0.619,
< 0.01]. Decision curves also demonstrated that the nomogram had higher overall net benefits than that of the TNM staging system. Subgroup analyses revealed that the nomogram was a favorable prognostic parameter in advanced NSCLC (
< 0.05). The results were internally validated using the validation cohorts.
The proposed nomogram with inflammatory factors resulted in an accurate prognostic prediction in patients with advanced NSCLC.
The proposed nomogram with inflammatory factors resulted in an accurate prognostic prediction in patients with advanced NSCLC.
