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Only under acidic conditions (pH 2), NSAIDs were highly sorbed onto microplastics mainly ruled by hydrophobic interactions. Among NSAIDs tested, diclofenac exhibited the highest sorption coefficients to microplastics. Polyethylene particles exhibited the highest affinity for NSAIDs. The outdated test methodologies for terrestrial animals have limited the progress of soil ecotoxicology to some extent. To improve the behavioral testing of earthworms, a terrestrial model animal, a sensitive optical-based method for detecting locomotor activity was established. The method measured the fine quantified position offsets of each earthworm in place of a conventional overall response rate, which provided the feasibility for accurate analyses and comparisons. By setting appropriate thresholds, the time proportions of medium and burst states (mid-burdur%) could be an optimized endpoint with an ideal balance in output stability and sensitivity. In addition, we chose the head-end, which is the most flexible part of the earthworm, other than whole body to further elevate the sensitivity in indicating the changed traits. Using octopamine, serotonin, and a serial-dose of lindane exposure, the practice credibility of the test method was validated. Our developed locomotor test method overcame the innate characteristics of the earthworm, and was expected to provide a powerful phenotypic tool for ecological and ecotoxicological studies using earthworms and similar invertebrates. Assessing the impacts of irrigation on water resources is crucial to effectively understanding how water is withdrawn for irrigation purposes. Consequently, the extraction of water from rivers, reservoirs and aquifers for irrigation purposes usually exceeds the net requirement for irrigation due to water lost in its delivery from source to the crop fields. In this this study, we have proposed a model for incorporating seasonal water loss from storage reservoir and conveyance canal into the crop water footprint of irrigated sugarcane. By taking into consideration the duration of seasonal irrigation water release for sugarcane production, we present a method for allocation of blue water footprint using savannah sugar irrigation district as case study. Results have shown that significant volume of water is evaporated seasonally due to irrigation of sugarcane, despite the introduction of an allocation factor to account of evaporation loss to irrigation. For the study period of 2007-2017, the reservoir is the main contributor to water loss by evaporation, it accounts for an average seasonal water loss of 1.1 × 108 m3, followed by evapotranspiration from the crop field 0.26 × 108 m3 and then seepage and evaporation losses from the canal 7.9 × 104 m3. The average seasonal blue water footprint of sugarcane for the period considered is 877 m3/ton which exceeds the global average 209 m3/ton. Plans to expand hectares of cultivated land by the company to boost sugarcane productivity, coupled with the ongoing effort to incorporate hydroelectric power plant to the existing dam to augment electric power supply in the district, will greatly influence the availability water resources in the region. This study highlighted the need for a comprehensive evaluation of water use in irrigated agriculture and may serve as an indicator for optimizing future objectives and strategies associated with water resource planning globally. The model SYNOPS was developed to calculate national risk indicators for assessing the aquatic and terrestrial risk potential of pesticides in Germany. For Switzerland, a national aquatic risk indicator is currently being developed based on SYNOPS. It aims at evaluating long-term trends in aquatic risks based on changing pesticide usage and risk mitigation measures. In a first step, parameters of the fate models of SYNOPS were parametrized for the Swiss geographical context. Apart from data about pesticides and their specific usage, SYNOPS requires information about climate, soil and site-specific properties and crop stage. Based on these inputs, SYNOPS calculates the predicted environmental concentrations (PEC) of pesticides in water bodies and the associated exposure-toxicity-ratios (i.e., risks). To consider the effects of risk mitigation measures in risk indicators, a realistic representation of the contribution of different routes of entry (run-off, erosion, drainage, drift) is essential. To parametrize icator using SYNOPS. Betulaceae family is a dominant tree pollen type in the atmosphere at Northwest Spain, being a major cause of allergenic rhinitis or asthma symptoms. Alnus pollen cause symptoms in the 9-20% of the total hay fever sufferers mean while the 41.89% of patients present a positive skin-prick-test for Betula allergens. Aln g1 and Bet v1 aeroallergens belong to PR-10 protein family and are associated to cross-reactivity processes. Airborne pollen and aeroallergens from Alnus and Betula were sampled during their Main Pollen Season from 2016 to 2019. Pollen sampling was conducted by means of a Hirst volumetric trap and aeroallergens were sampled using a Multi Vial Cyclone Sampler. Alnus flowering took place from January to February, with an average duration of 44 days. Betula bloom occurred from April to May with an average pollen season of 33 days. The major innovation of our study was the first detection of Aln g1 allergens in the atmosphere by using Bet v1 antibodies. This fact verified the cross-reactivity between the main allergens of Betula and Alnus pollen. Along the study period, an average of 18 days/year and 14 days/year with high potential risk of allergy due to Alnus pollen and allergen respectively, was registered. For Betula an average of 16 days/year with high potential risk of allergy due to pollen and 22 days for allergen was registered. The main consequence of the successive bloom of both trees would be the so-called "priming effect". Urban population sensitized to Betula pollen could suffer allergic symptoms during winter (as a consequence of Alnus), and in spring with the manifestation of higher symptoms under low birch pollen grain levels in the atmosphere. CDK4/6-IN-6 The traditional information to prevent allergies, such as the airborne pollen concentrations, should be combined with the data of aeroallergen to identify the real allergenic load in the atmosphere.

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