Mohamadcarlton2702

Conclusions Staff are aware of the need for creating a structured environment for patients in PTCS and less aware of communication-specific strategies aiming at helping patients' expression, which underlines the need to emphasize these strategies as part of CPT in this type of setting.Primary Objective Inform the production of a screening tool for language in children with concussion. The authors predicted that children with a recent concussion would perform the cognitive-linguistic tasks more poorly, but some tasks may be more sensitive to concussion than others.Methods & Procedures 22 elementary school aged children within 30 days of a concussion and age-matched peers with no history of concussion were assessed on a battery of novel language and cognitive-linguistic tasks. They also completed an auditory attention task and the Raven's Colored Progressive Matrices.Main Outcomes & Results Children with a recent concussion scored significantly more poorly in novel tasks targeting category identification, grammaticality judgments, and recognizing target words presented in a short story than their age-matched peers with no such injury history. All observed effects had moderate sizes. Inclusion of these three tasks significantly improved prediction of concussion status over symptom score when controlling for the age of participants.Conclusions The finding supports continued investigation of targeted linguistic tasks in children following concussion, particularly in the domains of semantic and syntactic access and verbal working memory. Future work developing brief language assessments specifically targeting children in this age range may provide a valuable addition to the existing tools for identifying the effects of concussion.Increasing number of literatures highlighted lncRNA maternally expressed gene 3 (MEG3) as an emerging target for hypoxic-ischaemic brain damage (HIBD). This study attempted to assess the role of MEG3 in a cell model of HIBD. Expression of MEG3 in PC12 cells was suppressed by siRNA-mediated transfection, after which the cells were subjected to hypoxia. Cell viability, apoptosis, migration and the expression of related proteins were assessed. Furthermore, the downstream gene of MEG3 and its downstream signalling pathways were explored. We found that, down-regulation of MEG3 prevented hypoxic injury in PC12 cells, as hypoxia induced viability loss, apoptosis and migration repression were attenuated by transfection with MEG3 siRNA. Meanwhile, MEG3 acted as a miR-21 sponge. The neuroprotective functions of MEG3 silence were flattened when miR-21 was suppressed. Moreover, the deactivation of PI3K/AKT pathway and the activation of NF-κB pathway induced by hypoxia were attenuated by MEG3 silence. As expected, the effects of MEG3 silence on these two signalling were via miR-21. In conclusion, the neuroprotective effects of MEG3 silence on PC12 cells injured by hypoxia were observed in this study. Mechanistically, the neuroprotective effects of MEG3 silence on PC12 cells were via sponging miR-21 and thus regulating PI3K/AKT and NF-κB pathways.HIGHLIGHTSMEG3 is highly expressed in PC12 cells following hypoxic injury;Silence of MEG3 prevents hypoxia-induced cell damage in PC12 cells;MEG3 acts as a miR-21 sponge;MEG3 sponges miR-21 to regulate PI3K/AKT and NF-κB pathways.Background Recent studies noted the limited applicability of Glasgow Coma Scale (GCS) for elderly patients with Traumatic Brain Injury (TBI). However, the dichotomic distinction between "elderly" and "non-elderly" does not cover the full span of influence of age on GCS presentation.Objective To analyze the influence of age on GCS scores of patients with isolated TBI.Methods A retrospective study of 18,534 patients hospitalized due to isolated TBI recorded in the Israeli National Trauma Registry in 1997-2017. The GCS scores were compared between four age-groups 20-44, 45-64, 65-74 and 75+ years old. Additional factors included patient's sex, Abbreviated Injury Scores (AIS) and injury circumstances.Results GCS scores increased continuously with age at all AIS levels. check details The trend was significant even after adjustment for patient's sex and injury circumstances. The angle of the trend was different in various injury circumstances, with GCS scores of victims of Road Traffic Accidents sharply increasing after age of 44 and that of the patients hospitalized after falling from own height surging after age of 64.Conclusions Screening procedures for patients with TBI should give a greater weight to the actual age of adults, as well as to the circumstances of their injury.OBJECTIVE To investigate the effect of drug treatment combined with psychological intervention on mental disorders in patients with persistent moderate-severe allergic rhinitis. METHODS Sixty patients with persistent moderate-severe allergic rhinitis who met the criteria were randomly divided into 2 groups control group and experimental group. The control group was only given medication, whereas the experimental group was given psychological intervention on the basis of the same medication. Cognitive behavioral therapy was used for psychological intervention. After 12 weeks of treatment, Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), and rhinoconjunctivitis quality of life questionnaire (RQLQ) were used to evaluate the changes in anxiety, depression, and quality of life before and after treatment. RESULTS The SAS and SDS scores of the control group after treatment were lower than those before treatment, and the difference was statistically significant. Similarly, the SAS and SDS scores owith psychological intervention is better than drug treatment alone.This study sought to compare the biomechanical parameters of the lower extremities during a countermovement jump in elderly people who are engaged in frequent practice of tai chi chuan (TCG) and in the general population of healthy elderly people (HG). Each group included 12 participants. Ten Vicon Motion System infrared cameras and two Kistler force plates were employed for measurement. The jump height, duration, centre of mass (COM) displacement, joint ROM, and upward velocity were analysed in this study. Motion analysis and force platform data were combined to calculate joint moments and powers during the takeoff phase. The data were analysed using independent sample t-tests. The results showed that the tai chi chuan practitioner group (0.13 m) achieved 44% higher jump heights (p less then  0.05). The COM displacement during squatting was lower in the TCG (0.25 m) than in the HG (0.19 m) (p less then  0.05). The knee and ankle ROMs of the TCG were higher than those of the HG (p less then  0.05). Peak knee moment 23% and peak knee power 32% higher in TCG compared to the HG (p less then  0.