Wilkinsonupton5671

Complicated intussusceptions and right hemicolectomy were the most common indication and procedure respectively. Proportion of right hemicolectomies was more in infants than older children (p=0.0103) while ileal resection was higher in older children (p less then 0.001). Post-operative complications were seen in 35.8% and mortality rate was 8.7%. CONCLUSION Complicated intussusception is the main acquired indication for intestinal resection. Right hemicolectomies and ileal resections were done mainly during infancy and beyond infancy respectively.BACKGROUND Childhood mortality is a serious public health concern. Periodic assessment of its trend is important in evaluating the pattern and planning intervention strategies. OBJECTIVE The study aimed at evaluating the childhood mortality ( less then 18 years) in Delta State University Teaching Hospital, Nigeria. METHODS This is a descriptive retrospective study from 1st January, 2016 to 31st December, 2018 using mortality data from the institution. RESULTS A total of 1,692 children were admitted during the study period, out of which 203 died, giving a mortality rate of 12%. They were composed of 126 males and 77 females with a mean age of 17.5 months. Neonates, children aged between 28 days and 1 year, between 12 months and 5 years and between 5 years and 18 years accounted for 46.8%, 14.3%, 16.3%, and 22.7% of the cases respectively. Sepsis, prematurity, birth asphyxia, congenital anomalies and bilirubin encephalopathy accounted for 30 (31.6%), 22 (23.2%), 15 (15.8%), 13(13.7%) and 5 (5.3%) of the cases respectively. Septicemia (31.0%) and bronchopneumonia (13.9%) were the leading causes of infant death. Leading causes of under-5 mortality (excluding infants) include burns, malaria, anemia/anemic heart failure, traumatic injury, meningitis and pneumonia, accounting for 18.2%, 18.2%, 12.1%, 12.1%, 9.1% and 9.1% of the cases respectively. Among children 5-18 years, meningitis/encephalitis, malignancies, renal disease, road traffic accident (RTA) and burns accounted for 9(19.6%), 8 (17.4%), 4 (8.7%), 4 (8.7%) and 3 (6.5%) cases respectively. CONCLUSION We observed excess of male mortality, with neonates being the most vulnerable. These deaths are attributed to preventable causes. There is need to intensify intervention programmes to reverse this trend.BACKGROUND There are few reports on socioeconomic status (SES) of patients with chronic kidney disease (CKD) in Nigeria and indeed Africa, South of the Sahara. Identifying SES as an important factor for disability in people with CKD would provide a means for early identification of those at risk and, possible intervention. OBJECTIVE To determine the SES of CKD patients attending renal clinic in the University of Nigeria Teaching Hospital. METHODS Cross-sectional descriptive design was adopted using pretested questionnaire to elicit data on SES (age, place of residence, household asset ownership, source of drinking water; source of cooking energy; and type of toilet facility) from one hundred and forty-five (145) CKD patients attending renal clinic in the University of Nigeria Teaching Hospital. Principal component analysis was used to classify the SES into five quintiles. RESULTS Majority of the respondents (patients) in stages 4 and 5 CKD, constituting 17.2% and 39.3% respectively were from the lower SES. There was significant correlation between SES and age of the patients; place of residence; hypertension history; ownership of some household assets; source of drinking water; source of cooking energy; and type of toilet facility. Terfenadine in vitro CONCLUSION This study demonstrated that many of our patients were from the lower SES. It is recommended that both governmental and non-governmental agencies should help these patients with some form of health insurance to alleviate their healthcare cost burden.BACKGROUND Colorectal carcinoma is the third most common cancer worldwide. With the push towards targeted therapy in the management of metastatic colorectal carcinoma using anti-EGFR monoclonal antibody, this study aimed to determine the rate of Epidermal Growth Factor Receptor (EGFR) expression in Colorectal Carcinoma, compare the clinicopathological features with the EGFR status and determine if EGFR expression in colorectal carcinoma is of any prognostic significance. MATERIALS AND METHODS The clinical and demographic data of 54 patients who had colectomy specimens sent to the Pathology Department at the UCH, Ibadan were reviewed to confirm the diagnosis, tumour grade and other clinico-pathological parameters. EGFR expression was assessed on the archival Formalin Fixed Paraffin Embedded (FFPE) blocks using immunohistochemical staining technique. Pearson's chi square test was used to correlate the EGFR status and the clinicopathological features of the tumour. RESULTS Epidermal Growth Factor Receptor was expressed in 85.2% of colorectal carcinoma cases. There was an association between EGFR status, depth of tumour invasion and tumour size having P value of 0.05 and 0.043 respectively but there was no association with other clinicopathological parameters. There was no correlation between intensity of staining, percentage of tumour stained and clinicopathological parameters. CONCLUSION This study demonstrates that most cases of colorectal carcinoma diagnosed in the University College Hospital, Ibadan, in the study period showed expression for EGFR. We found that there was an association between depth tumour invasion and tumour size with EGFR expression, suggesting that most EGFR positive colorectal carcinomas are large and show deeper invasion by the tumours. Thus, EGFR positive tumours most likely have poor prognosis.BACKGROUND There is a global rise in the prevalence of diabetes mellitus and pre-diabetes is a fore-runner to type-2 diabetes. Pre-diabetes is reversible, therefore, measures should be taken to halt or slow down its progression to frank diabetes. AIM The study aimed to evaluate the prevalence of pre-diabetes and diabetes amongst staff of ABUTH, Zaria and identify some cardiovascular risks associated with them. METHODS A cross-sectional analytical study carried out on 377 healthcare workers who presented at the Medical out-patient department of ABUTH, Zaria in response to an invitation for the 2017 World Diabetes Day free medical screening. HbA1c was assessed via Immunofluorescence method. The difference in HbA1c amongst healthcare workers was determined by One-way Analysis of Variance with Post-hoc Bonferroni test. Cardiovascular risk associations were assessed via Multiple Binary Logistic Regression. RESULTS Pre-diabetes and diabetes prevalence were 19.4% and 6.5% respectively. There were 28.6% undiagnosed diabetic healthcare workers.