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05). Concerning men that did not present lifestyle risks associated, the motility, midpiece and tail abnormalities, and teratozoospermia index were significantly worse on obese individuals comparing to overweight men (p  less then  .05). Thus, patients should also be recommended to control their weight and to have a BMI under 30 kg/m2 . © 2020 Blackwell Verlag GmbH.Hybrid organic-inorganic perovskite solar cells have recently emerged as one of the most promising low-cost photovoltaic technologies. The remarkable progress of perovskite photovoltaics is closely related to advances in interfacial engineering and development of charge selective interlayers. Herein we present the synthesis and characterization of a fused azapolyheteroaromatic small molecule, namely anthradi-7-azaindole (ADAI), with outstanding performance as hole transporting layer in perovskite solar cells with inverted architecture. Its molecular arrangement, induced by hydrogen bond-directed self-assembly, favors a suitable morphology of the perovskite layer, reducing the effects of recombination as revealed by light intensity dependence, photoluminescence and electroluminescence studies. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Lung adenocarcinoma (LUAD), as a form of non-small cell lung cancer (NSCLC), is the most frequently diagnosed lung cancer worldwide. To date, a few biomarkers have been reported to provide valuable information in guiding LUAD treatment. The aim of our study was to explore the functional role of pyrroline-5-carboxylate reductase 1 (PYCR1) in LUAD. Based on Oncomine database, we found that PYCR1 was highly expressed in LUAD tissues. We also confirmed an abnormal increase of PYCR1 expression in LUAD cell lines and patients' tissues. IBMX inhibitor Through Kaplan-Meier plotter database, we further studied the prognostic values of PYCR1. The outcomes indicated that overexpressed PYCR1 associated with poor prognosis among LUAD patients. To further study the function of PYCR1 in LUAD, cell counting kit-8, colony-forming, scratch wound healing, and Transwell assays were conducted. The results suggested that knockdown of PYCR1 curbed cell proliferation, migration, and invasion in LUAD cell lines. Subsequently, we identified 50 top genes positively and negatively correlated with PYCR1 in LUAD, and conducted biological pathway enrichment analysis of these genes. Among those enriched pathways, we selected JAK/STAT signaling pathway for further analysis. The results of Western blot assays revealed that PYCR1 knockdown significantly increased the expression of Bcl-2 and c-Myc, and the phosphorylation level of JAK2 and STAT3. Taken together, this study unearthed that PYCR1 knockdown could inhibit tumor growth and affect the JAK/STAT signaling pathway in LUAD. This study may contribute to a better understanding of PYCR1 in LUAD and provide a potential biomarker for cancer prognosis. © 2020 Wiley Periodicals, Inc.Pediatric allogeneic hematopoietic cell transplantation (HCT) practices differ from those of adults, particularly the heterogeneity of transplantable non-malignant diseases and the lower incidence of Graft-versus-Host-Disease (GVHD). Several guidelines regarding the management of acute (a) GVHD in adult HCT have been published. We aimed to capture the real-life approaches for pediatric aGVHD prophylaxis/treatment, and data from 75/193 (response rate 39%) EBMT centers (26 countries) were included, representing half (48%) of the pediatric EBMT-HCT activity. Results with ≥75% approval from respondents (74/75) for GVHD prophylaxis after myeloablative HCT for malignancies partially contradict published guidelines single-agent cyclosporine A (CsA) was used for matched-sibling donor HCT in 47%; blood CsA levels were reported lower; the relapse risk in malignant diseases influenced GVHD prophylaxis with early withdrawal of CsA; distinct longer duration of CsA was employed in non-malignant diseases. Most centers used additional anti-thymocyte globulin for matched-unrelated and mismatched donor HCT, but not for matched-siblings. Regarding prophylaxis in non-myeloablative conditioning (mainly for non-malignant diseases) responses showed broad heterogeneity. High conformity was found for first-line treatment; however, results regarding steroid-refractory aGVHD indicate an earlier diagnosis in children. Our findings highlight the need for standardized pediatric approaches towards aGVHD prophylaxis/treatment differentiated for malignant and non-malignant underlying diseases. This article is protected by copyright. All rights reserved.PURPOSE This study aimed to determine the most reliable scanning strategy and scanner type, using a new protocol for assessing the accuracy (trueness and precision) of intraoral scan data. MATERIALS AND METHODS Five different maxillary and mandibular typodont pairs (n = 10) and 2 intraoral scanners were used for the study. A reference scan for each arch was obtained with an industrial scanner. Scanning strategies were classified into 2 continuous methods-continuous scan in horizontal direction (CH group) and continuous scan with vertical rotation in anterior region (CV group)-and 1 segmental method (S group). In the CH group, the scanner head was maintained mostly in a horizontal position. In the CV group, the scanners were rotated 180° around the anterior tooth region to allow smooth scanning through the area. The intraoral scan data were individually superimposed over their corresponding reference scan data. Raw data of the distances between paired surface points were extracted from the superimposed pairs of intraoral scanners should be minimized. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Cutaneous tuberculosis is an uncommon entity with several clinical forms recognized. Histopathologically, most cases are characterized by granulomatous inflammation and caseating necrosis, although less common findings, including vasculitis, have also been described. We report a 55-year-old male with a history of recently diagnosed dermatomyositis receiving immunosuppression with mycophenolate mofetil and prednisone, who developed multifocal soft tissue abscesses and an indurated erythematous plaque on the back. Skin biopsy of the back revealed a necrotizing medium-vessel vasculitis. Mycobacterium tuberculosis was detected in the skin via acid-fast bacilli stain and confirmed by tissue culture and polymerase chain reaction. Cutaneous findings improved rapidly with antituberculosis therapy. This case illustrates an uncommon clinical and histopathologic presentation of disseminated tuberculosis. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.