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Clinical innovation and research on maternal-fetal interventions have become an essential for the development of perinatal medicine. In this paper, we present an ethical argument that the professional virtue of integrity should guide perinatal investigators.

We present an historical account of the professional virtue of integrity and the key distinction that this account requires between intellectual integrity and moral integrity.

We identify implications of both intellectual and moral integrity for innovation, research, prospective oversight, the role of equipoise in randomized clinical trials, and organizational leadership to ensure that perinatal innovation and research are conducted with professional integrity.

Perinatal investigators and those charged with prospective oversight should be guided by the professional virtue of integrity. Leaders in perinatal medicine should create and sustain an organizational culture of professional integrity in fetal centers, where perinatal innovation and research should be conducted.

Perinatal investigators and those charged with prospective oversight should be guided by the professional virtue of integrity. Leaders in perinatal medicine should create and sustain an organizational culture of professional integrity in fetal centers, where perinatal innovation and research should be conducted.

Clinical evaluation of vitamin D status is conventionally performed by measuring serum levels of a single vitamin D metabolite, 25-hydroxyvitamin D predominantly by immunoassay methodology. However, this neglects the complex metabolic pathways involved in vitamin D bioactivity, including two canonical forms D3 and D2, bioactive 1,25-dihydroxy metabolites and inactive 24-hydroxy and other metabolites.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) can measure multiple analytes in a sample during a single run with high sensitivity and reference level specificity. We therefore aimed to develop and validate a LC-MS/MS method to measure simultaneously 13 circulating vitamin D metabolites and apply it to 103 human serum samples.

The LC-MS/MS method using a Cookson-type derivatization reagent phenyl-1,2,4-triazoline-3,5-dione (PTAD) quantifies 13 vitamin D metabolites, including mono and dihydroxy-metabolites, as well as CYP11A1-derived D3 and D2 metabolites in a single run. The lower limit of quantitation was 12.5pg/mL for 1,25(OH)

D3 with accuracy verified by analysis of National Institute of Standards and Technology (NIST) 972a standards. Quantification of seven metabolites (25(OH)D3, 25(OH)D2, 3-epi-25(OH)D3, 20(OH)D3, 24,25(OH)

D3, 1,25(OH)

D3 and 1,20

(OH)

D3) was consistently achieved in human serum samples.

This profiling method can provide new insight into circulating vitamin D metabolite pathways forming the basis for improved understanding of the role of vitamin D in health and disease.

This profiling method can provide new insight into circulating vitamin D metabolite pathways forming the basis for improved understanding of the role of vitamin D in health and disease.

L. is largely used by diabetic population, but its bark is scarcely investigated. The major aim of this study was to investigate the effect of the hydro-methanolic extract and fractions of

L. barks on normoglycemic and diabetic rats through the evaluation of some biochemical parameters.

Phenolic enriched extracts were investigated for their effect on normoglycemic and diabetic rats through the determination of fasting blood glucose levels in short- and long-term. As well as plasma total cholesterol, triglycerides, insulin, urea, creatinine, alanine amino transferase (ALT) and aspartate amino transferase (AST) levels were measured after 28days of treatment. Furthermore, the phytochemical composition was assessed by standard methods.

Among the different extracts tested, the n-Butanol fraction presented the highest amounts of total phenolic, total flavonoids and flavonol contents (745±0.6mgGAEg

, 162±0.78mgCEg

and 56.02±0.92mgQEg

, respectively) and it found to be themost effective to decrease plasma total cholesterol, triglycerides and FGLs in treated diabetic rats in both short- and long-term treatment, mainly the dose 200mg/kg after 28days of treatment which found to be more effective than glibenclamide. This fraction also revealed pronounced improvement in liver and renal profiles.

L. barks had an important antidiabetic role similar to the reference glibenclamide. This may be related to the high contents of phenolic compounds.

J. regia L. barks had an important antidiabetic role similar to the reference glibenclamide. This may be related to the high contents of phenolic compounds.With the continuous increase in the use of social networks, social mining is steadily becoming a powerful component of digital phenotyping. In this paper we explore social mining for the classification of self-diagnosed depressed users of Reddit as social network. We conduct a cross evaluation study based on two public datasets in order to understand the impact of transfer learning when the data source is virtually the same. We further complement these results with an experiment of transfer learning in post-partum depression classification, using a corpus we have collected for the matter. Our findings show that transfer learning in social mining might still be at an early stage in computational research and we thoroughly discuss its implications.

Postmenopausal women are at greater risk of depression. click here Depression may negatively affect the quality of life of women. An emotional freedom technique (EFT) is an evidence-based therapy combining cognitive and exposure components with acupressure. This study aimed to evaluate the effect of EFT on depression in postmenopausal women.

This was a randomized controlled trial in which 88 women with mild to moderate depression recruited from a menopausal clinic in Ahvaz, Iran, and randomly assigned into two groups of EFT (n=44) and control for sham therapy (n=44). Women in the EFT group received two sessions of training and asked to continue EFT for 8weeks, one time per day. The Beck Depression Inventory (BDI2) completed by women before and after the intervention. The control group received training on sham acupressure points similar to the intervention group. Data collected using a demographic and BDI2. Women requested to complete the BDI2 before and after the intervention. The independent t-test, chi-square, and ANCOVA were used to analyze data.