Mcfaddenpayne1978
This novel algorithm is able to produce a 3D orientation distribution function (ODF) for any RFN including, models of nonwovens produced with various manufacturing parameters, experimentally verified and validated with X-ray µCT. Also, it can compute 2D ODFs of various types of RFNs to evaluate 2D behaviour of fibrous structures. The obtained results are useful for applications in many fields including finite element analysis, computational fluid dynamics, additive manufacturing, etc.Billions of travelers pass through airports around the world every year. Airports are a relatively common location for sudden cardiac arrest when compared with other public venues. An increased incidence of cardiac arrest in airports may be due to the large volume of movement, the stress of travel, or adverse effects related to the physiological environment of airplanes. Having said that, airports are associated with extremely high rates of witnessed arrests, bystander interventions (eg. MLN8237 purchase CPR and AED use), shockable arrest rhythms, and survival to hospital discharge. Large numbers of people, a high density of public-access AEDs, and on-site emergency medical services (EMS) resources are probably the major reasons why cardiac arrest outcomes are so favorable at airports. The success of the chain of survival found at airports may imply that applying similar practices to other public venues will translate to improvements in cardiac arrest survival. Airports might, therefore, be one model of cardiac arrest preparedness that other public areas should emulate.
Symptoms may differ between frail and non-frail patients presenting to Emergency Departments (ED). However, the association between frailty status and type of presenting symptoms has not been investigated. We aimed to systematically analyse presenting symptoms in frail and non-frail older emergency patients and hypothesized that frailty may be associated with nonspecific complaints (NSC), such as generalised weakness.
Secondary analysis of a prospective, single centre, observational all-comer cohort study conducted in the ED of a Swiss tertiary care hospital. All presentations of patients aged 65 years and older were analysed. At triage, presenting symptoms and frailty were systematically assessed using a questionnaire. Patients with a Clinical Frailty Scale (CFS) > 4 were considered frail. Presenting symptoms, stratified by frailty status, were analysed. The association between frailty and generalised weakness was tested by logistic regression.
Overall, 2'416 presentations of patients 65 years and older were analysed. Mean age was 78.9 (SD 8.4) years, 1'228 (50.8%) patients were female, and 885 (36.6%) patients were frail (CFS > 4). Generalised weakness, dyspnea, localised weakness, speech disorder, loss of consciousness and gait disturbance were recorded more often in frail patients, whereas chest pain was reported more often by non-frail patients. Generalised weakness was reported as presenting symptom in 166 (18.8%) frail patients and in 153 (10.0%) non-frail patients. Frailty was associated with generalised weakness after adjusting for age, gender and elevated National Early Warning Score 2 (NEWS) ≥ 3 (OR 1.19, CI 1.10-1.29, p < 0.001).
Presenting symptoms differ in frail and non-frail patients. Frailty is associated with generalised weakness at ED presentation.
Presenting symptoms differ in frail and non-frail patients. Frailty is associated with generalised weakness at ED presentation.The Mental Health Act as amended 2007 democratised who could qualify for the Approved Mental Health Professional (AMHP) role to include not only social workers, but psychologists, occupational therapists, and nurses. The amendments raised questions on how to appropriately train AMHPs from the professional groups without social work education to have adequate skills and decision-making capacity when considering the use of compulsory powers. Essential to the AMHP role is the obligation to 'bear in mind the social perspective', which incorporates the social dimensions to a persons mental health presentation and is considered a safeguard against the erroneous detention of service users. However, despite claims to further professionalise AMHPs there has been a difficulty defining what AMHP expertise is. This paper draws upon 'theories of professionalisation' to argue that the genericism movement and the adoption of New Public Management has limited the professionalisation of AMHPs and therefore adequate implementation of 'the social perspective'.The retention and lipophilicity characteristics of four oral antidiabetic drugs namely; Metformin (MET), Linagliptin (LIN), Empagliflozin (EMP), and Dapagliflozin (DAP) were evaluated by a facile TLC-spectrodensitometric method. The developed method was validated and employed for simultaneous determination of the investigated drugs in their synthetic quaternary mixture, single- and multi-component tablets, and human plasma. The separation of the cited drugs was achieved using silica gel G 60F254-TLC plates and a mobile system consisting of n-butanol water glacial acetic acid (7 3 1, v/v/v). After scanning at 234 nm, good linearities (10.0-2000.0 ng/band for each drug) and correlation coefficients (r = 0.99882-0.99972) with lower limits of detection and quantitation (2.17-3.58 and 6.57-10.85 ng/band, respectively) were statistically calculated. The obtained recoveries (98.35-101.38%) proved the wide applicability of the established method for concurrent estimation of the studied antidiabetics in fixed-dose combination tablets and human plasma. Besides, the present work was extended to estimate the lipophilicity parameters of the targeted drugs. Molecular lipophilicity (RM), relative lipophilicity (RM0), and lipophilic descriptor (C0) were calculated for MET, LIN, EMP, and DAP. Good correlations (r = 0.8729-0.9933) between the chromatographic retention data and molecular descriptors of the studied drugs were attained. The obtained results confirmed the poor lipophilicity of MET and LIN compared to EMP and DAP. Lastly, understanding the lipophilicity of the cited drugs may be promising for the future design of safer and more effective formulations for diabetes mellitus, cancer, and Alzheimer's disease. Over and above, this work may be further applied to QSAR studies.
Meniscal allograft transplantation (MAT) has been developed as a treatment for meniscal deficiency. Despite promising outcomes, there are no real-time methods to evaluate graft survivorship and predict functional outcomes.
Assessment of serum and urine biomarkers could be used to develop biomarker panels-prognostic (1- and 3-month postsurgical time points) and diagnostic (6-month time point)-based on strong associations with clinically relevant outcome metrics obtained 6 months after surgery.
Descriptive laboratory study.
Twelve adult purpose-bred research hounds were included and underwent medial meniscal release to induce meniscal deficiency. Three months after meniscal release surgery, medial menisci were replaced with fresh-frozen meniscus (n = 4), fresh meniscus (n = 4), or fresh meniscotibial osteochondral allograft (n = 4) such that a spectrum of pain and functional outcomes could be anticipated. Serum and urine from all dogs were collected preoperatively and at 1, 3, and 6 months after MAT surfit for the primary pain-related outcome, VAS (
= 0.516). Across diagnostic biomarker panels, a panel including serum MMP-1 and MMP-3 and urine PINP and TIMP-1 was fit for %TPI (
= 0.863). Separately, a panel including urine CTX-I, CTX-II, IL-8, MMP-2, and TIMP-1 was fit as diagnostic biomarkers for the VAS for pain (
= 0.438).
Biomarker panels of selected serum and/or urine proteins can model clinically relevant metrics for function and pain in a preclinical model of MAT.
Biomarker panels could be used to provide real-time diagnostic and prognostic data regarding outcomes after MAT.
Biomarker panels could be used to provide real-time diagnostic and prognostic data regarding outcomes after MAT.
Academic burnout is a common issue that interferes with the role shift from nursing students to qualified nurses and aggravates a shortage of workforce in global healthcare system. According to the Areas of Worklife Scale, developed by Maslach and Leiter, there are six dimensions that encompass the major antecedents of burnout. Therefore, it's well worth an exploration to understand academic burnout and its' underlying mechanism based on the theoretical instrument. Specifically, academic burnout, professional attitude, academic self-efficacy and smartphone addiction were selected as observation variables after widely literature review.
The purpose of this study is to examine academic burnout and figure out the relationships between academic burnout, professional attitude, academic self-efficacy and smartphone addiction among nursing students.
A cross-sectional study.
The study was conducted in a nursing department in Anhui province in eastern China.
1445 nursing students.
Academic burnout, professc burnout.
Studies have assessed attitudes toward, knowledge of, and beliefs regarding providing care for lesbian, gay, bisexual, and transgender (LGBT) patients among student nurses, nurses, and nursing educators individually, but few studies have compared these aspects among these groups.
To examine the attitudes toward, knowledge of, and beliefs regarding providing care for LGBT patients among student nurses, nurses, and nursing educators in Taiwan.
Cross-sectional survey.
The study was advertised in 8 nursing schools, 14 nursing associations, 209 nursing homes, and 2 online chatrooms in Taiwan.
A total of 1150 participants were recruited 447 student nurses, 475 nurses, and 228 nursing educators.
Data were collected between August 2021 and January 2022 through a questionnaire with five sections demographics, knowledge of LGBT health, the Knowledge about Homosexuality Questionnaire, the Attitude Toward Lesbian and Gay Men Scale, and the Gay Affirmative Practice Scale.
The results suggest that the participants had limited knowledge of LGBT health. The nursing educators had the lowest scores for knowledge of LGBT health and homosexuality and the most negative attitudes toward lesbians and gay men among the groups; however, they were most likely to report their beliefs regarding providing nursing care to LGBT patients than the other two groups.
The results indicate the importance of providing nursing educators with training courses and resources related to culturally competent care to improve education for nursing students and care for LGBT patients.
The results indicate the importance of providing nursing educators with training courses and resources related to culturally competent care to improve education for nursing students and care for LGBT patients.
Peer feedback is an effective learning tool for students, improving academic performance and learning satisfaction. In nursing education, it has been widely used in the assimilation of clinical skills. However, the effectiveness of peer feedback as an educational intervention needs to be evaluated holistically beyond intervention research, considering students' perception to garner valuable insights to guide the successful implementation of peer feedback.
This review aimed to consolidate the qualitative evidence exploring perceptions and experiences of nursing students who have used peer feedback as a learning tool.
Qualitative systematic review.
Nine databases were searched from their respective inception dates until December 2021.
Data were extracted using a modified Joanna Brigg's qualitative data extraction tool, and the Critical Appraisal Skills Programme (CASP) tool was used to appraise the quality of included studies. Meta-synthesis was done using Sandelowski and Barroso's two-step approach.
The review included 14 studies and the synthesis identified an overarching theme 'feeling lost to finding ways' and four themes (1) An uncomfortable learning experience; (2) confronting disagreements; (3) greater engagement with learning; and (4) value added beyond learning.
