Haugaardfitzpatrick7701

A novel shock-resistant, self-generating triboelectric nanogenerator (SS-TENG) with high-speed impact energy-harvesting and safeguarding properties was developed by assembling Kevlar fiber and conductive shear-stiffening gel. The SS-TENG with energy-harvesting property generated a maximum power density of 5.3 mW/m2 with a voltage of 13.1 V under oscillator compression and could light up light-emitting diode arrays. Owing to the energy absorption effect, the as-designed SS-TENG could dissipate impact forces from 2880 to 1460 N, showing anti-impact performance under the drop hammer impact. It also sensed the loading forces by outputting 36.4 V. Functionalized as a self-powered sensor, SS-TENG monitored various human movements and provided protection from hammer impact. Interestingly, a wearable sole array with high sensitivity and a fast response could distinguish toe in/out motions. More importantly, this functional SS-TENG presented excellent anti-impact behavior, which dissipated 94% of kinetic energy under bullet-shooting excitation. It also gathered high speed ballistic energy, which outputted a maximum power density of 3 mW/m2. To this end, this SS-TENG with a protection effect and the ability to harvest various impact energy showed promising applications in new power sources, intelligent wearable systems, and safeguard areas.Autophagy plays an important role in maintaining tumor cell progression and survival in response to metabolic stress. Thus, the regulation of autophagy can be used as a strategy for anticancer therapy. Here, we report dutomycin (DTM) as a novel autophagy enhancer that eventually induces apoptosis due to excessive autophagy. Also, human serine protease inhibitor B6 (SERPINB6) was identified as a target protein of DTM, and its novel function which is involved in autophagy was studied for the first time. We show that DTM directly binds SERPINB6 and then activates intracellular serine proteases, resulting in autophagy induction. Inhibitory effects of DTM on the function of SERPINB6 were confirmed through enzyme- and cell-based approaches, and SERPINB6 was validated as a target protein using siRNA-mediated knockdown and an overexpression test. In a zebrafish xenograft model, DTM showed a significant decrease in tumor area. selleck inhibitor Furthermore, the present findings will be expected to contribute to the expansion of novel basic knowledge about the correlation of cancer and autophagy by promoting active further research on SERPINB6, which was not previously considered the subject of cancer biology.Here, we put forward an effective strategy to regulate the interface structure of carbon nanotubes/polyaniline (CNTs/PANI) composite films and improve their thermoelectric (TE) properties by sequential dedoping-redoping treatment. Dedoping induces conductive resistance-undoped PANI to enhance the energy barrier between CNTs and PANI, leading to a greatly increased Seebeck coefficient and deteriorated conductivity. Subsequently, upon the redoping process, the electrical conductivity is dramatically improved owing to the generated conductive PANI chains, while Seebeck coefficient is maintained at 90% of the dedoped composites. This yields a significantly improved power factor of 407 μW m-1 K-2 from the as-prepared composites (234 μW m-1 K-2), which is the highest value among those of all the reported CNTs/PANI composites. The outstanding TE performanceis probably ascribed to the multiple interface structure of the PANI composite generated from incomplete dedoping and redoping processes, contributing to the enhanced carrier-filtering effect to retain a relatively high Seebeck coefficient and efficient charge transport to improve conductivity. Furthermore, the flexible TE device generates a high power of 1.5 μW at ΔT = 50 K, demonstrating the applicability of this composite for energy-harvesting electronic devices.

Studies using simulation-based programs for empathy enhancement have been conducted mostly for health profession students and medical care providers in Western countries. No empirical research has been conducted for non-medical care providers of older adults in community settings in Asian countries. The purposes of this mixed-methods study were to explore experiences and perceived usability of non-medical care providers of older adults in a simulation-based empathy enhancement program; and to examine if the program is effective in improving empathy and relevant outcomes.

104 non-medical care providers of older adults in South Korea participated in a simulation-based empathy enhancement program in 2018. Data were collected using self-reported questionnaires for effectiveness testing, a program evaluation questionnaire, and individual interviews and analyzed using statistical tests and thematic analysis.

Care providers showed higher levels of empathy and lower levels of stress and burnout after the program participation (p<0.05). Qualitative findings supported the improved attitude and care strategies, increased empathy towards older adults, preparing for their own aging, and restoration of emotional stability through the participation in the program.

This study suggests that the simulation-based program is useful in promoting empathic responses of non-medical care providers working with older adults.

This study suggests that the simulation-based program is useful in promoting empathic responses of non-medical care providers working with older adults.

This study evaluated the validity of self-reported smartphone usage data against objectively-measured smartphone usage data by directly tracking the activities in the participants' smartphone among Chinese adolescents and young adults in Hong Kong.

A total of 187 participants were recruited (mean age 19.4, 71.7% female) between 2017 and 2018. A smartphone usage tracking app was installed on all participants' smartphone for 7 consecutive days. After the 7-day monitoring period, they completed a selfadministered questionnaire on smartphone usage habits.

Although the correlation between self-reported and objectively-measured total smartphone usage time was insignificant (ρ=-0.10, p=0.18), in three out of the four usage domains were positively and significantly correlated, namely social network (ρ=0.21, p=0.005), instant messaging (ρ=0.27, p<0.001), and games (ρ=0.64, p<0.001). Participants' self-report of the total time spent on smartphones exceeded the objective data by around 760 min per week (self-reported 1,930.