Reesfreedman3146

Recent strides have allowed the consolidation of routine imaging modalities with highly accurate reconstruction software to aid the operating surgeon generate patient-specific three-dimensional models. In this preliminary report, we describe our initial experience using a patient-specific reconstruction software to guide surgical resection for 2 patients with non-small-cell lung cancer. Digital imaging and communications in medicine data from patient chest CT scans was configured into IQQA BodyImaging Lung software to generate highly accurate maps of airways, vessels and segments as well as estimates of lung volumes. Models generated aided us in planning appropriate lung cancer resection procedures.

We investigated rates of cognitive decline at three-year follow-up from initial examination in people reporting mild traumatic brain injury (mTBI) with loss of consciousness (LOC) more than a year prior to initial examination. GSK-3 signaling pathway We examined the role of social support as predictors of preserved cognitive function in this sample.

Analyses were conducted on 440 participants who had self-reported LOC of < 1min, 350 with LOC of 1-20min, and 10,712 healthy controls, taken from the Canadian Longitudinal Study on Aging (CLSA), a nationwide study on health and aging.

People who reported at baseline that they had experienced mTBI with LOC of 1-20min more than a year prior were 60% more likely to have experienced global cognitive decline than controls at three-year follow-up. Cognitive decline was most apparent on measures of executive functioning. Logistic regression identified increased social support as predictors of relatively preserved cognitive function.

mTBI with longer time spent unconscious (i.e., LOC 1-20min) is associated with greater cognitive decline years after the head injury. Perceived social support, particularly emotional support may help buffer against this cognitive decline.

mTBI with longer time spent unconscious (i.e., LOC 1-20 min) is associated with greater cognitive decline years after the head injury. Perceived social support, particularly emotional support may help buffer against this cognitive decline.

This study investigates whether the within-person associations between a recent major financial crisis and deficits in cognitive performance vary across the lifecourse.

Four waves of data from 7442 participants (49% men) spanning 12-years and comprising three narrow age birth cohorts (baseline age 20-25, 40-45, and 60-65) were drawn from a representative prospective survey from Canberra, Australia (1999-2014). Cognitive performance was assessed by the California Verbal Leaning Test (CVLT) immediate recall trails, Symbol Digit Modalities Test (SDMT), Backwards Digitspan (BDS), and Trail Making Test B (TMT B). A single item from the Threatening Life Experiences Questionnaire assessed self-reported major financial crisis in the past 6-months. Multi-variable adjusted fixed effect regression models tested the time-dependent association between financial crisis and cognition.

A recent financial crisis coincided with contemporaneous declines in CVLT (Mean change = -0.14, 95% CI = -0.262, -0.025), SDMT (Mean change = -0.08, 95% CI = -0.147,-0.004) and TMT-B (Mean change = -0.17, 95% CI = -0.293,-0.039) for adults in the oldest age group, and these associations were larger than in the younger age groups. In contrast, there was an overall association between financial crisis and deficits in BDS (Mean change = -0.06, 95% CI = -0.105, -0.007), with weak evidence of stronger associations in mid-life relative to other age groups. These associations were independent of changes in health and socio-economic circumstances.

This study provides important new evidence that financial difficulties in later life are potent stressors associated with occasion specific deficits in cognitive performance.

This study provides important new evidence that financial difficulties in later life are potent stressors associated with occasion specific deficits in cognitive performance.Exposed surfaces of mammals are colonized with 100 trillion indigenous bacteria, fungi, and viruses, creating a diverse ecosystem known as the human microbiome. The gut microbiome is the richest microbiome and is now known to regulate postnatal skeletal development and the activity of the major endocrine regulators of bone. Parathyroid hormone (PTH) is one of the bone-regulating hormone that requires elements of the gut microbiome to exert both its bone catabolic and its bone anabolic effects. How the gut microbiome regulates the skeletal response to PTH is object of intense research. Involved mechanisms include absorption and diffusion of bacterial metabolites, such as short-chain fatty acids, and trafficking of immune cells from the gut to the bone marrow. This review will focus on how the gut microbiome communicates and regulates bone marrow cells in order to modulate the skeletal effects of PTH.

In young adults, the ability to verbally recall instructions in working memory is enhanced if the sequences are physically enacted by the participant (self-enactment) or the experimenter (demonstration) during encoding. Here we examine the effects of self-enactment and demonstration at encoding on working memory performance in older and younger adults.

Fifty young (18-23 years) and 40 older (60-89 years) adults listened to sequences of novel action-object pairs before verbally recalling them in the correct order. There were three different encoding conditions spoken only, spoken + demonstration, and spoken + self-enactment. We included two different levels of difficulty to investigate whether task complexity moderated the effect of encoding condition and whether this differed between age groups.

Relative to the spoken only condition, demonstration significantly improved young and older adults' serial recall performance, but self-enactment only enhanced performance in the young adults, and this boost was smaller than the one gained through demonstration.

Our findings suggest that additional spatial-motoric information is beneficial for older adults when the actions are demonstrated to them, but not when the individual must enact the instructions themselves.

Our findings suggest that additional spatial-motoric information is beneficial for older adults when the actions are demonstrated to them, but not when the individual must enact the instructions themselves.